| Mechanisms of actin filament severing and elongation by formins. | Mechanisms of actin filament severing and elongation by formins.
Palmer NJ, Barrie KR, Dominguez R., | 08/14/2024 |
| INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death. | INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death.
Labat-de-Hoz L, Fernández-Martín L, Correas I, Alonso MA., Free PMC Article | 07/12/2024 |
| Functional genetic variants of the disulfidptosis-related INF2 gene predict survival of hepatitis B virus-related hepatocellular carcinoma. | Functional genetic variants of the disulfidptosis-related INF2 gene predict survival of hepatitis B virus-related hepatocellular carcinoma.
Wei J, Wen Q, Zhan S, Cao J, Jiang Y, Lian J, Mai Y, Qiu M, Liu Y, Chen P, Lin Q, Wei X, Wei Y, Huang Q, Zhang R, He S, Yuan G, Wei Q, Zhou Z, Yu H. | 04/24/2024 |
| Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer. | Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer.
Ding Y, Lv Z, Cao W, Shi W, He Q, Gao K., Free PMC Article | 01/30/2024 |
| FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division. | FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division.
Zhang H, Zhao Y, Wang J, Li J, Xia J, Lin Y, Zhong Y, Cao X, Jin J, Li X, Yang W, Ye M, Jin X., Free PMC Article | 06/23/2023 |
| INF2 mutations in patients with a broad phenotypic spectrum of Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis. | INF2 mutations in patients with a broad phenotypic spectrum of Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis.
Park JH, Kwon HM, Nam DE, Kim HJ, Nam SH, Kim SB, Choi BO, Chung KW. | 03/9/2023 |
| Role of formin INF2 in human diseases. | Role of formin INF2 in human diseases.
Zhao Y, Zhang H, Wang H, Ye M, Jin X. | 03/26/2022 |
| Steroid Resistant Nephrotic Syndrome with Clumsy Gait Associated With INF2 Mutation. | Steroid Resistant Nephrotic Syndrome with Clumsy Gait Associated With INF2 Mutation.
Sinha R, Maiti R, Das D, Mandal K. | 09/25/2021 |
| Multiple formin proteins participate in glioblastoma migration. | Multiple formin proteins participate in glioblastoma migration.
Heuser VD, Kiviniemi A, Lehtinen L, Munthe S, Kristensen BW, Posti JP, Sipilä JOT, Vuorinen V, Carpén O, Gardberg M., Free PMC Article | 02/6/2021 |
| FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes. | FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlöndorff JS, Pollak MR., Free PMC Article | 09/5/2020 |
| Study used lysine-to-glutamine mutations to map the relevant lysines on actin for INF2 regulation. K50Q- and K61Q-actin, when bound to CAP2, inhibit full-length INF2 but not INF2 lacking inhibitory domain (DID). CAP WH2 domain binds INF2-DID with submicromolar affinity but has weak affinity for actin monomers, while INF2-C-terminal diaphanous autoregulatory domain binds CAP/K50Q-actin 5-fold better than CAP/WT-actin. | Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.
A M, Fung TS, Francomacaro LM, Huynh T, Kotila T, Svindrych Z, Higgs HN., Free PMC Article | 05/16/2020 |
| our results indicated that oxidative stress-mediated HaCaT cells apoptosis could be reversed by Tan IIA treatment via reducing INF2-related mitochondrial stress in a manner dependent on the ERK signaling pathway. | Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.
Xie Z, Zhou Y, Duan X, Yang L. | 01/18/2020 |
| The phenotypic feature of the pedigree is autosomal dominant intermediate Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis, which may be attributed to the c.341G>A mutation of the INF2 gene. | [Analysis of a pedigree with autosomal dominant intermediate Charcot-Marie-Tooth disease type E and nephropathy].
Fu J, Ma M, Pang M, Yang L, Li G, Song J, Zhang J. | 09/28/2019 |
| INF2 is a novel pro-apoptotic inducer of oxidative injury in epidermal cells. | INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.
Chen Z, Wang C, Yu N, Si L, Zhu L, Zeng A, Liu Z, Wang X. | 06/15/2019 |
| INF2 seems to be not only the cause of FSGS, but also of ESRD of unknown etiology. | Mutational screening of inverted formin 2 in adult-onset focal segmental glomerulosclerosis or minimal change patients from the Czech Republic.
Safarikova M, Stekrova J, Honsova E, Horinova V, Tesar V, Reiterova J., Free PMC Article | 04/20/2019 |
| INF2-mediated actin polymerization on the endoplasmic reticulum stimulates mitochondrial division by two independent mechanisms: (1) mitochondrial calcium uptake, leading to inner mitochondrial membrane constriction; and (2) Drp1 oligomerization, leading to outer mitochondrial membrane constriction. | INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.
Chakrabarti R, Ji WK, Stan RV, de Juan Sanz J, Ryan TA, Higgs HN., Free PMC Article | 11/3/2018 |
| Studies indicate that INF2, a formin, that is mutated in hereditary renal and neurodegenerative disorders. | Coordination of microtubule acetylation and the actin cytoskeleton by formins.
Fernández-Barrera J, Alonso MA., Free PMC Article | 11/3/2018 |
| Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. | Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.
Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI., Free PMC Article | 07/13/2017 |
| hese findings reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer. | Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, Tang L, Ma J, Xiao J, Zhang E, Zhu J, Zhang B, Zhao SM, Li Y, Ren S, Huang H, Yu L, Wang C., Free PMC Article | 06/3/2017 |
| All individuals with INF2 mutations presenting with a thrombotic microangiopathy also had atypical hemolytic uremic syndrome risk haplotypes, potentially accounting for the genetic pleiotropy | Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease.
Challis RC, Ring T, Xu Y, Wong EK, Flossmann O, Roberts IS, Ahmed S, Wetherall M, Salkus G, Brocklebank V, Fester J, Strain L, Wilson V, Wood KM, Marchbank KJ, Santibanez-Koref M, Goodship TH, Kavanagh D., Free PMC Article | 05/27/2017 |
| Propose that examination of INF2 expression may help to differentiate minimal change disease from focal segmental glomerulosclerosis and evaluate the clinical severity of steroid resistance nephrotic syndrome in children. | Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.
Tamura H, Nakazato H, Kuraoka S, Yoneda K, Takahashi W, Endo F. | 03/4/2017 |
| FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. | The formins FHOD1 and INF2 regulate inter- and intra-structural contractility of podosomes.
Panzer L, Trübe L, Klose M, Joosten B, Slotman J, Cambi A, Linder S. | 12/17/2016 |
| The authors propose Spire1C isoform cooperates with INF2 to regulate actin assembly at endoplasmic reticulum-mitochondrial contacts. | A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division.
Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, Spudich J, Lippincott-Schwartz J., Free PMC Article | 06/28/2016 |
| Report novel mutations in the inverted formin 2 gene of Chinese families contributing to focal segmental glomerulosclerosis. | Novel mutations in the inverted formin 2 gene of Chinese families contribute to focal segmental glomerulosclerosis.
Xie J, Hao X, Azeloglu EU, Ren H, Wang Z, Ma J, Liu J, Ma X, Wang W, Pan X, Zhang W, Zhong F, Li Y, Meng G, Kiryluk K, He JC, Gharavi AG, Chen N. | 06/11/2016 |
| Assembly and turnover of short actin filaments by the formin INF2 and profilin. | Assembly and turnover of short actin filaments by the formin INF2 and profilin.
Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN., Free PMC Article | 12/5/2015 |