| the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported. | Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB. | 01/11/2020 |
| Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes. | A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin.
Luo Y, Akama T, Okayama A, Yoshihara A, Sue M, Oda K, Hayashi M, Ishido Y, Hirano H, Hiroi N, Katoh R, Suzuki K. | 02/10/2018 |
| Study illustrates early developmental changes in the cellular and subcellular localization of flotillin-1 in the rat visual cortex and suggests that flotillin-1 was transported mainly into presynaptic terminals | Developmental changes in the flotillin-1 expression pattern of the rat visual cortex.
Nakadate K. | 12/19/2015 |
| Reggie-1 nas reggie-2 are localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1. | Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.
Fernow I, Icking A, Tikkanen R. | 12/5/2011 |
| Flot-1 enhances the formation of glutamatergic synapses but not GABAergic synapses in cultured neurons from the hippocampus. | Flotillin-1 promotes formation of glutamatergic synapses in hippocampal neurons.
Swanwick CC, Shapiro ME, Vicini S, Wenthold RJ., Free PMC Article | 08/13/2011 |
| flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption | Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL., Free PMC Article | 02/26/2011 |
| Data reveal a flotillin-1 signaling pathway for hippocampal neurite branching that is regulated by synaptic adhesion-like molecule 4. | Flotillin-1 mediates neurite branching induced by synaptic adhesion-like molecule 4 in hippocampal neurons.
Swanwick CC, Shapiro ME, Vicini S, Wenthold RJ. | 01/22/2011 |
| NMDARs were significantly more colocalized with flot-1 than flot-2 in cultured hippocampal neurons | NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins.
Swanwick CC, Shapiro ME, Yi Z, Chang K, Wenthold RJ. | 01/21/2010 |
| Data suggest that flotillin-1 participates in the developmental process of Sertoli cells and is involved in the regulation of spermatogenesis. | Immunohistochemical study of flotillin-1 in the rat testis during postnatal development.
Kim H, Moon C, Shin T. | 01/21/2010 |
| Flotillin-1 is an essential molecule in IgE receptor-mediated mast cell activation, and regulates the kinase activity of Lyn in lipid rafts. | Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells.
Kato N, Nakanishi M, Hirashima N. | 01/21/2010 |
| basic structural units of reggie microdomains are reggie homo- and hetero-tetramers, which are dependent on the presence of reggie-1 | Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains.
Solis GP, Hoegg M, Munderloh C, Schrock Y, Malaga-Trillo E, Rivera-Milla E, Stuermer CA., Free PMC Article | 01/21/2010 |
| Flotillin-1 localizes to cholesterol-rich membrane microdomains in vivo and could be an ultrastructural raft marker in neural tissue. | Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue.
Kokubo H, Helms JB, Ohno-Iwashita Y, Shimada Y, Horikoshi Y, Yamaguchi H. | 01/21/2010 |
| Significant caveolin and flotillin-1 in peritubular myoid cells(PMC). Punctate caveolin staining pattern at PMC cell surface characteristic of caveolar location. More ubiquitous, stage-specific distribution of flotillin-1 among testicular cell types. | Characterization of membrane rafts isolated from rat sertoli cell cultures: caveolin and flotillin-1 content.
Evans WE 4th, Coyer RL, Sandusky MF, Van Fleet MJ, Moore JG, Nyquist SE. | 01/21/2010 |
| Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin. | Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging.
Dremina ES, Sharov VS, Schöneich C. | 01/21/2010 |
| In situ hybridization histochemical studies revealed the presence of flotillin-1 mRNA in discrete neuronal cells of the substantia nigra, locus coeruleus, cortex, hippocampus, hypothalamus, thalamus, motor nuclei, nucleus basalis, and raphe nucleus. | Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.
Jacobowitz DM, Kallarakal AT. | 01/21/2010 |
| Flotillin-1 immunoreactivity is increased in some Sertoli and inflammatory cells (especially in ED1-positive activated macrophages) in testicular torsion. | Immunohistochemical study of flotillin-1 in rat testis with ischemia/reperfusion injury.
Jeong CW, Kim H, Kim S, Kim SH, Moon C, Shin T. | 01/21/2010 |