| NAT10-mediated ac[4]C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis. | NAT10-mediated ac(4)C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis.
Xing P, Zhou M, Sun J, Wang D, Huang W, An P., Free PMC Article | 10/30/2024 |
| Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis. | Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis.
Ma H, Huang Y, Tian W, Liu J, Yan X, Ma L, Lai J., Free PMC Article | 06/26/2024 |
| TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner. | TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
Chen L, Ma Y, Ma X, Liu L, Jv X, Li A, Shen Q, Jia W, Qu L, Shi L, Xie J. | 11/6/2023 |
| METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the Intracerebral hemorrhage progression. | METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the Intracerebral hemorrhage progression.
Zhang L, Wang X, Che W, Zhou S, Feng Y. | 05/23/2023 |
| Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis. | Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis.
Wei XB, Jiang WQ, Zeng JH, Huang LQ, Ding HG, Jing YW, Han YL, Li YC, Chen SL., Free PMC Article | 07/9/2022 |
| urinary transferrin might be further explored as a wider biomarker of an important mechanism of predisposition to renal damage. | Urinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterations.
Casanova AG, Vicente-Vicente L, Hernández-Sánchez MT, Prieto M, Rihuete MI, Ramis LM, Del Barco E, Cruz JJ, Ortiz A, Cruz-González I, Martínez-Salgado C, Pescador M, López-Hernández FJ, Morales AI. | 06/6/2020 |
| inhibition of c-Abl minimizes receptor recycling pathways and results in chaperone-dependent trafficking of the TfR1 to the lysosome for degradation. | The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.
Cao H, Schroeder B, Chen J, Schott MB, McNiven MA., Free PMC Article | 05/7/2017 |
| the effects of hepcidin expression and hepcidin peptide on brain iron contents, iron transport across the brain-blood barrier, iron uptake and release, and also the expression of TfR1, DMT1, and Fpn, were investigated. | Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.
Du F, Qian ZM, Luo Q, Yung WH, Ke Y. | 05/21/2016 |
| Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats. | Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
Ding D, Salvi R, Roth JA. | 04/4/2015 |
| Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increass duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold. | Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
Thomas CE, Gaffney-Stomberg E, Sun BH, O'Brien KO, Kerstetter JE, Insogna KL. | 08/3/2013 |
| Data suggest that soluble transferrin receptor (sTfR) indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training. | The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.
Tian Y, Zhao J, Zhao B, Gao Q, Xu J, Liu D. | 10/6/2012 |
| Under the condition of copper deficiency, the expression of hepcidin mRNA in liver was lowered and the expression of transferrin receptor mRNA was enhanced. | [Effect of copper deficiency on iron metabolism in rats].
Wang K, Wang C, Liu B, Jiang S. | 08/11/2012 |
| up-regulation of transferrin may be a biomarker for oxidative stress in Gst-p positive lesions in liver tumors | Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M. | 04/12/2010 |
| Results indicate that TfR promotes glioma progression by two mechanisms, an increase in proliferation rate and glutamate production, the latter mechanism providing space for the progressing tumor mass. | Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.
Chirasani SR, Markovic DS, Synowitz M, Eichler SA, Wisniewski P, Kaminska B, Otto A, Wanker E, Schäfer M, Chiarugi P, Meier JC, Kettenmann H, Glass R. | 01/21/2010 |
| This protein is identified and characterized in liver stellate cells. | Identification and characterization of the hepatic stellate cell transferrin receptor.
Bridle KR, Crawford DH, Ramm GA., Free PMC Article | 01/21/2010 |
| MPP(+)-dependent aconitase inactivation, Tf-iron uptake, and oxidant generation result in the depletion of intracellular tetrahydrobiopterin, leading to the uncoupling of nNOS activity | 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide.
Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B. | 01/21/2010 |
| Increased expression of Tfrc in response to hypoxia leads to excess cellular uptake of iron which may be damaging to the cells. Melatonin administration in hypoxic rats may prove to be beneficial as it reduced the Tfrc expression. | Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment.
Kaur C, Sivakumar V, Ling EA. | 01/21/2010 |
| cellular locations identified by immunofluorescence | Cellular location of proteins related to iron absorption and transport.
Simovich MJ, Conrad ME, Umbreit JN, Moore EG, Hainsworth LN, Smith HK. | 01/21/2010 |
| transferrin receptor gene expression is increased during postischemic rat liver reperfusion | Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion.
Tacchini L, Fusar Poli D, Bernelli-Zazzera A, Cairo G. | 01/21/2010 |
| a region of the TfR that can potentially interact with hsc70 | Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes.
Géminard C, De Gassart A, Blanc L, Vidal M. | 01/21/2010 |
| data show that brain cells have the capacity to maintain minimum iron levels during iron deficiency which may be associated with increased iron-Tf uptake, stabilization of TfR mRNA, or increased Tf mRNA translation efficiency in specific cell types | Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats.
Han J, Day JR, Connor JR, Beard JL. | 01/21/2010 |
| These data suggest that alveolar type II (but not type I) cells express functional transferrin receptor in adult rat alveolar epithelium. | Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers.
Widera A, Beloussow K, Kim KJ, Crandall ED, Shen WC. | 01/21/2010 |
| Both iron accumulation and deprivation modulate the synthesis of ferritin and TfR in astrocytes and that protein synthesis is required to prevent iron-mediated toxicity in astrocytes | Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.
Hoepken HH, Korten T, Robinson SR, Dringen R. | 01/21/2010 |