| HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation. | HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation.
Liu Q, Yan X, Yuan Y, Li R, Zhao Y, Fu J, Wang J, Su J., Free PMC Article | 02/28/2024 |
| Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity. | Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity.
Nam MK, Shin HA, Yun H, Yoo SA, Rhim H. | 01/21/2023 |
| Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes. | Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes.
Gao M, Qiu Y, Cao T, Li D, Wang J, Jiao Y, Chen Z, Huang J., Free PMC Article | 12/31/2022 |
| Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt. | Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L., Free PMC Article | 10/22/2022 |
| Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis. | Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis.
Meng H, Sun LK, Su J, Yan WY, Jin Y, Luo X, Jiang XR, Wang HL. | 02/5/2022 |
| Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. | Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L. | 11/27/2021 |
| HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis. | HtrA2 is required for inflammatory responses in BMDMs via controlling TRAF2 stability in collagen-induced arthritis.
Xu Z, Lin J, Xie Y, Tang H, Xie J, Zeng R. | 02/20/2021 |
| Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. | Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.
Liu D, Wu L, Wu Y, Wei X, Wang W, Zhang S, Yi M, Li J, Liu H, Ma X., Free PMC Article | 10/3/2020 |
| This study showed that ALDH2 deficiency upregulated the mitochondrial serine protease Omi/HtrA2, and that ALDH2 deficiency leads to greater mitochondrial ROS production, but homeostasis can be maintained via an appropriate stress response. | Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T, Yamanaka Y, Sakai A, Nakayama KI, Kawamoto T, Kitagawa K, Nakazato K. | 08/1/2020 |
| Findings indicate the expression of both HtrA serine peptidase 2 (Omi/HtrA2) and tumor supressor p53 (p53) nucleoprotein were elevated in aging heart. | p53 mediated transcription of Omi/HtrA2 in aging myocardium.
Wu L, Liu D, Wu Y, Wei X, Wang Z, Wang W, Zhang S, Yang H, Yi M, Liu H. | 06/27/2020 |
| Suppressing HtrA2/Omi expression promotes hepatic fibrogenesis via modulating mitochondrial reactive oxygen species generation; these novel mechanistic insights involving the regulation of mitochondrial homeostasis by HtrA2/Omi may be of importance for developing new therapeutic strategies for hepatic fibrosis. | Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Hur W, Kang BY, Kim SM, Lee GW, Kim JH, Nam MK, Rhim H, Yoon SK., Free PMC Article | 06/20/2020 |
| HtrA2 protease activity regulates autophagy and controls the magnitude and duration of inflammasome signaling by preventing prolonged accumulation of the inflammasome adaptor apoptosis-associated speck-like protein containing a caspase-recruitment domain. | The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.
Rodrigue-Gervais IG, Doiron K, Champagne C, Mayes L, Leiva-Torres GA, Vanié P Jr, Douglas T, Vidal SM, Alnemri ES, Saleh M., Free PMC Article | 10/19/2019 |
| The therapeutic function of HtrA2 in inflammatory diseases is linked with Th17 development and the STAT3 pathway in splenocytes. | HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Lee SH, Moon YM, Seo HB, Kim SY, Kim EK, Yi J, Nam MK, Min JK, Park SH, Rhim H, Cho ML., Free PMC Article | 06/23/2018 |
| Study show that overexpression of mitochondrial Omi/HtrA2 induces cardiac apoptosis and dysfunction. | Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.
Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H., Free PMC Article | 05/26/2018 |
| Omi/HtrA2-HAX-1 chain played a significant role in mitochondrial homeostasis. | Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart.
Liu X, Lei J, Wang K, Ma L, Liu D, Du Y, Wu Y, Zhang S, Wang W, Ma X, Liu H. | 03/24/2018 |
| Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration. | Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
Casadei N, Sood P, Ulrich T, Fallier-Becker P, Kieper N, Helling S, May C, Glaab E, Chen J, Nuber S, Wolburg H, Marcus K, Rapaport D, Ott T, Riess O, Krüger R, Fitzgerald JC. | 12/17/2016 |
| Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma cells; E2F1 is a substrate of Omi. | Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1.
Ma Q, Hu QS, Xu RJ, Zhen XC, Wang GH., Free PMC Article | 07/30/2016 |
| Protease Omi impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice. | Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice.
Wu JY, Li M, Cao LJ, Sun ML, Chen D, Ren HG, Xia Q, Tao ZT, Qin ZH, Hu QS, Wang GH., Free PMC Article | 07/30/2016 |
| The NG2 proteoglycan protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2. | The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J., Free PMC Article | 05/21/2016 |
| Loss of Omi protease activity results in an abnormal increase of GSK3b, leading to the degradation of PGC-1a, which causes an impairment of mitochondrial biogenesis and induces neurodegeneration. | The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
Xu R, Hu Q, Ma Q, Liu C, Wang G., Free PMC Article | 03/12/2016 |
| Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. | Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Patterson VL, Zullo AJ, Koenig C, Stoessel S, Jo H, Liu X, Han J, Choi M, DeWan AT, Thomas JL, Kuan CY, Hoh J., Free PMC Article | 12/19/2015 |
| Our findings indicate that radiation-inducible gene therapy may have potential to be a more effective and specific therapy for uveal melanoma because the therapeutic gene can be spatially or temporally controlled by exogenous radiation. | Radiation-inducible HtrA2 gene enhances radiosensitivity of uveal melanoma OCM-1 cells in vitro and in vivo.
Zhang F, Yu T, Yi CL, Sun XF. | 05/16/2015 |
| Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. | Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS. | 07/5/2014 |
| Phosphorylated HtrA2/Omi cleaves beta-actin and decreases the amount of filamentous actin (F-actin) in the cytosol. | p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion.
Yamauchi S, Hou YY, Guo AK, Hirata H, Nakajima W, Yip AK, Yu CH, Harada I, Chiam KH, Sawada Y, Tanaka N, Kawauchi K., Free PMC Article | 05/24/2014 |
| The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. | The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.
Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schütze S, Adam D., Free PMC Article | 02/22/2014 |