| Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). | Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
Yamada T, Cohen SM, Lake BG. | 11/27/2021 |
| nuclear expression virtually disappeared in the late stage of cholestatic injury, after an initial increase | Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Gabbia D, Pozza AD, Albertoni L, Lazzari R, Zigiotto G, Carrara M, Baldo V, Baldovin T, Floreani A, Martin S., Free PMC Article | 08/18/2018 |
| Metabolism of methiocarb and carbaryl does not alter CAR activity. | Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.
Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S. | 04/15/2017 |
| results are the first report that CaR plays an important role in Ca(2+) signaling involved in cardiac fibrosis through the phospholipase C- inositol 3,4,5 phosphate (PLC-IP3) pathway. | Calcium sensing receptor promotes cardiac fibroblast proliferation and extracellular matrix secretion.
Zhang X, Zhang T, Wu J, Yu X, Zheng D, Yang F, Li T, Wang L, Zhao Y, Dong S, Zhong X, Fu S, Xu CQ, Lu F, Zhang WH. | 08/6/2016 |
| Report a CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat CYP3A1 gene. | A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
Gamou T, Habano W, Terashima J, Ozawa S. | 05/28/2016 |
| Serum 5-HT regulates the expression of Mrp2 and P-gp, and the underlying mechanism may be related to the altered expression of the nuclear receptor constitutive androstane receptor. | Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Shao YY, Huang J, Ma YR, Han M, Ma K, Qin HY, Rao Z, Wu XA. | 05/7/2016 |
| CAR ligands might augment the endocrine disrupting potential of AhR activators by an induction of the hepatic AhR. | Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.
Schraplau A, Schewe B, Neuschäfer-Rube F, Ringel S, Neuber C, Kleuser B, Püschel GP. | 03/28/2015 |
| Dissociation of CAR nuclear receptor from thyroid hormone receptors results in down-regulation of hepatic cytochrome P450-PB2 (CYP2B)1. | Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke.
Bing Y, Zhu S, Jiang K, Dong G, Li J, Yang Z, Yang J, Yue J. | 03/29/2014 |
| CAR nuclear receptors are activated following ethyl tertiary-butyl ether administration leading to tumorigenesis. | Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways.
Kakehashi A, Hagiwara A, Imai N, Nagano K, Nishimaki F, Banton M, Wei M, Fukushima S, Wanibuchi H. | 01/25/2014 |
| FXR, PXR and CAR expression levels are decreased in the liver after intestinal ischemia-reperfusion; interleukin-6 is one of main causes the decreases in expressions of these receptors. | The decrease in farnesoid X receptor, pregnane X receptor and constitutive androstane receptor in the liver after intestinal ischemia-reperfusion.
Ogura J, Terada Y, Tsujimoto T, Koizumi T, Kuwayama K, Maruyama H, Fujikawa A, Takaya A, Kobayashi M, Itagaki S, Takahashi N, Hirano T, Yamaguchi H, Iseki K. | 07/6/2013 |
| Integrated investigation of PPAR, LXR, PXR, CAR regulatory mechanisms, signal transduction and transcriptional targets will provide insights into the pathogenesis of MS and offer valuable information for designing of drugs for MS treatment. | [All signs of metabolic syndrome in the hypertensive ISIAH rats are associated with increased activity of transcription factors PPAR, LXR, PXR, and CAR in the liver].
Pivovarova EN, Dushkin MI, Perepechaeva ML, Kobzev VF, Trufakin VA, Markel' AL. | 12/3/2011 |
| Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems. | The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems.
Kanno Y, Miyazaki Y, Inouye Y. | 09/27/2010 |
| Evidence for the involvement of CAR in transcriptional effects upon perfluoroalkyl acid exposure in the rat is reported. | Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species.
Ren H, Vallanat B, Nelson DM, Yeung LWY, Guruge KS, Lam PKS, Lehman-McKeeman LD, Corton JC. | 01/21/2010 |
| CAR mRNA levels did not differ in the large-for-gestational-age rats | Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats.
Ni S, Wang X, Wang J, Zeng S, Zhao Z. | 01/21/2010 |
| In rat hepatocytes CAR was induced by WY14643, a PPARalpha-agonist. A DR1 motif in the CAR promoter was necessary and sufficient for this control. | PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation.
Wieneke N, Hirsch-Ernst KI, Kuna M, Kersten S, Püschel GP. | 01/21/2010 |
| Constitutive CAR gene expression is regulated in part by CTP2B induction. | CAR expression and inducibility of CYP2B genes in liver of rats treated with PB-like inducers.
Pustylnyak VO, Gulyaeva LF, Lyakhovich VV. | 01/21/2010 |
| Intracellular localization of CAR is determined by the combined effects of nuclear localization signals, the xenochemical response signal, and the cytoplasmic retention region. | Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR.
Kanno Y, Suzuki M, Nakahama T, Inouye Y. | 01/21/2010 |
| CAR expressed in the hepatic preneoplastic lesions of rats is resistant to nuclear translocation and transactivation of the phenobarbital(PB) responsive enhancer module upon PB treatment. | Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.
Numazawa S, Shindo S, Maruyama K, Chibana F, Kawahara Y, Ashino T, Tanaka S, Yoshida T. | 01/21/2010 |