| Protective Role of MerTK in Diabetic Peripheral Neuropathy via Inhibition of the NF-kappaB Signaling Pathway. | Protective Role of MerTK in Diabetic Peripheral Neuropathy via Inhibition of the NF-κB Signaling Pathway.
Su X, Chen W, Fu Y, Wu B, Mao F, Zhao Y, Yang Q, Lan D., Free PMC Article | 08/14/2024 |
| MERTK in the rat trigeminal system: a potential novel target for cluster headache? | MERTK in the rat trigeminal system: a potential novel target for cluster headache?
Edvinsson JCA, Ran C, Olofsgård FJ, Steinberg A, Edvinsson L, Belin AC., Free PMC Article | 06/3/2024 |
| Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats. | Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats.
Pelé T, Giraud S, Joffrion S, Ameteau V, Delwail A, Goujon JM, Macchi L, Hauet T, Dkhissi F, Benzakour O., Free PMC Article | 12/18/2021 |
| Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK. | Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
Mao Y, Finnemann SC., Free PMC Article | 12/4/2021 |
| The long-term preservation of photoreceptors we observed indicates that MERTK-related form of inherited retinal degeneration, which has currently no cure, could be amenable to laser therapy or subretinal surgery, to extend the visual function, potentially for life. | Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.
Lorach H, Kang S, Dalal R, Bhuckory MB, Quan Y, Palanker D., Free PMC Article | 10/26/2019 |
| Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. We present here a comprehensive review of all reported MERTK disease causing variants with the associated phenotype | MERTK mutation update in inherited retinal diseases.
Audo I, Mohand-Said S, Boulanger-Scemama E, Zanlonghi X, Condroyer C, Démontant V, Boyard F, Antonio A, Méjécase C, El Shamieh S, Sahel JA, Zeitz C. | 06/15/2019 |
| Mertk protein expression in the Bone marrow mesenchymal stem cells was similar to that in the retinal pigment epithelial cells in the primary passage. | Mertk gene expression and photoreceptor outer segment phagocytosis by cultured rat bone marrow mesenchymal stem cells.
Peng RM, Hong J, Jin Y, Sun YZ, Sun YQ, Zhang P., Free PMC Article | 02/10/2018 |
| study concludes that activated microglia release Gal-3 and a neuraminidase that desialylates microglial and PC12 surfaces, enabling Gal-3 binding to PC12 (neuron-like) cells and their phagocytosis via Mer tyrosine kinase (MerTK). | Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.
Nomura K, Vilalta A, Allendorf DH, Hornik TC, Brown GC., Free PMC Article | 09/30/2017 |
| This study demonstrated that in Mertk mutation mice regulated the Expression pattern of Ccr2 and Cx3cr1. | Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
Kohno H, Koso H, Okano K, Sundermeier TR, Saito S, Watanabe S, Tsuneoka H, Sakai T., Free PMC Article | 06/28/2016 |
| A novel role of MERTK signaling in membrane trafficking in the Retinal Pigment Eepithelium that is likely to subserve mechanisms of phagosome formation. | MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.
Shelby SJ, Feathers KL, Ganios AM, Jia L, Miller JM, Thompson DA., Free PMC Article | 02/20/2016 |
| A deletion in the Mer tyrosine kinase (MerTK) receptor in Royal College of Surgeons rat that abolishes internalization of photoreceptor outer segments by retinal pigment epithelial cells. | Mertk in daily retinal phagocytosis: a history in the making.
Nandrot EF, Dufour EM. | 09/17/2011 |
| Key involvement of mer in outer segment phsgocytosis has been clearly proven. | The phagocytosis of os is mediated by the PI3-kinase linked tyrosine kinase receptor, mer, and is stimulated by GAS6.
Hall MO, Agnew BJ, Abrams TA, Burgess BL. | 01/21/2010 |
| Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. | Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells.
Feng W, Yasumura D, Matthes MT, LaVail MM, Vollrath D. | 01/21/2010 |