| RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Wang J, Miao Y, Wicklein R, Sun Z, Wang J, Jude KM, Fernandes RA, Merrill SA, Wernig M, Garcia KC, Südhof TC., Free PMC Article | 01/8/2022 |
| Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma. | Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma.
Hong JH, Kang S, Sa JK, Park G, Oh YT, Kim TH, Yin J, Kim SS, D'Angelo F, Koo H, You Y, Park S, Kwon HJ, Kim CI, Ryu H, Lin W, Park EJ, Kim YJ, Park MJ, Kim H, Kim MS, Chung S, Park CK, Park SH, Kang YH, Kim JH, Saya H, Nakano I, Gwak HS, Yoo H, Lee J, Hur EM, Shi B, Nam DH, Iavarone A, Lee SH, Park JB. | 04/24/2021 |
| the treatment of glioblastoma multiforme cells with TGFb1 suppressed NgR maturation. We showed that NgR and vimentin interact, which could be a possible mechanism for the suppression of NgR maturation. | Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme.
Kang YH, Han SR, Jeon H, Lee S, Lee J, Yoo SM, Park JB, Park MJ, Kim JT, Lee HG, Lee MS, Lee SH., Free PMC Article | 06/13/2020 |
| SATB2 and NRG1 overexpression induced many of the signaling pathways. | SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas.
Sato S, Maekawa R, Tamura I, Shirafuta Y, Shinagawa M, Asada H, Taketani T, Tamura H, Sugino N., Free PMC Article | 05/2/2020 |
| Nociceptin receptor ORL1 increases the cell surface expression of reticulon 4 receptor (NgR1) in HEK293T cells. | The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.
Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM., Free PMC Article | 09/21/2019 |
| miR-10 can promote microglia cell proliferation and inhibit the inflammatory cytokine secretion via targeting the NgR gene to down-regulate its expression. | MiR-10 targets NgR to modulate the proliferation of microglial cells and the secretion of inflammatory cytokines.
Wang W, Zhan R, Zhou J, Wang J, Chen S. | 01/5/2019 |
| Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing. | Genetic variation is associated with RTN4R expression and working memory processing in healthy humans.
Lo Bianco L, Attrotto MT, Torretta S, Masellis R, Rampino A, D'Ambrosio E, Di Giorgio A, Ferranti L, Fazio L, Gelao B, Blasi G, Bertolino A. | 05/12/2018 |
| NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke | Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.
Sozmen EG, Rosenzweig S, Llorente IL, DiTullio DJ, Machnicki M, Vinters HV, Havton LA, Giger RJ, Hinman JD, Carmichael ST., Free PMC Article | 04/14/2018 |
| Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428. | Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.
Thompson CA, Karelis J, Middleton FA, Gentile K, Coman IL, Radoeva PD, Mehta R, Fremont WP, Antshel KM, Faraone SV, Kates WR. | 09/23/2017 |
| Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2. | Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo.
Shi X, Yu W, Yang T, Liu W, Zhao Y, Sun Y, Chai L, Gao Y, Dong B, Zhu L. | 04/22/2017 |
| (188)Re-NGR-VEGI has the potential as a theranostic agent. | Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts.
Ma W, Shao Y, Yang W, Li G, Zhang Y, Zhang M, Zuo C, Chen K, Wang J. | 02/18/2017 |
| Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS. | A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population.
Amy M, Staehlin O, René F, Blasco H, Marouillat S, Daoud H, Vourc'h P, Gordon PH, Camu W, Corcia P, Loeffler JP, Palkovits M, Sommer WH, Andres CR. | 09/3/2016 |
| Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review] | Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface.
Saha N, Kolev M, Nikolov DB. | 08/1/2015 |
| NgR1 is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus. | The Nogo receptor NgR1 mediates infection by mammalian reovirus.
Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM, Dermody TS., Free PMC Article | 07/25/2015 |
| Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR). | LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
Meabon JS, De Laat R, Ieguchi K, Wiley JC, Hudson MP, Bothwell M., Free PMC Article | 06/27/2015 |
| This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene. | White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis.
Perlstein MD, Chohan MR, Coman IL, Antshel KM, Fremont WP, Gnirke MH, Kikinis Z, Middleton FA, Radoeva PD, Shenton ME, Kates WR., Free PMC Article | 08/30/2014 |
| knockdown of NgR enhanced invasion and adhesion but increased cell apoptosis in C6 cells, suggesting that Nogo-66/NgR might have complex effects on glioma cells. | RNA interference suppression of Nogo-66 receptor prevents Nogo-66-mediated inhibition of invasion and adhesion and simultaneously increases cell apoptosis in C6 cells.
Tong S, Xiong N, Shen J. | 04/12/2014 |
| Strong overexpression of Nogo receptor 1 in forebrain neurons impairs aspects of cognitive function but does not alter plaque load in plaque-forming transgenic animals. | Neuronal overexpression of Nogo receptor 1 in APPswe/PSEN1(ΔE9) mice impairs spatial cognition tasks without influencing plaque formation.
Karlsson TE, Karlén A, Olson L, Josephson A. | 09/28/2013 |
| After optic nerve crush injury, transgenic NgR1-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice. | Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways.
Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB, Strittmatter SM., Free PMC Article | 11/17/2012 |
| Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy. | Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy.
Xiong N, Shen J, Li S, Li J, Zhao H. | 05/26/2012 |
| Nogo receptor 3, a paralog of NgR1,functions as a NgR1 co-receptor for Nogo-66. | Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66.
Zhang L, Kuang X, Zhang J. | 03/17/2012 |
| These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. | Nogo receptor is involved in the adhesion of dendritic cells to myelin.
McDonald CL, Steinbach K, Kern F, Schweigreiter R, Martin R, Bandtlow CE, Reindl M., Free PMC Article | 02/25/2012 |
| The results of this study suggested that Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population. | Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population.
Pasaje CF, Bae JS, Park BL, Park CS, Kim BJ, Lee CS, Kim JW, Choi WH, Shin TM, Koh IS, Choi IG, Woo SL, Shin HD. | 11/12/2011 |
| A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. | A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1.
Huebner EA, Kim BG, Duffy PJ, Brown RH, Strittmatter SM., Free PMC Article | 07/30/2011 |
| Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance. | Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1.
Poon MW, Tsang WH, Chan SO, Li HM, Ng HK, Waye MM. | 05/21/2011 |