| The glucose transporter 2 regulates CD8[+] T cell function via environment sensing. | The glucose transporter 2 regulates CD8(+) T cell function via environment sensing.
Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, Sheikh MH, Solito E, Godinho SA, Bombardieri M, Smith DM, Cooper D, Iqbal AJ, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD, Marelli-Berg FM., Free PMC Article | 03/15/2024 |
| Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility. | Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility.
Liu L, Ma F, Liu Q, Yu X, Zeng X. | 06/2/2023 |
| Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy. | Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy.
Chen H, Zhang X, Liao N, Ji Y, Mi L, Gan Y, Su Y, Wen F., Free PMC Article | 12/17/2022 |
| Evidence for a Genotype-Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants. | Evidence for a Genotype-Phenotype Correlation in Patients with Pathogenic GLUT2 (SLC2A2) Variants.
Grünert SC, Schumann A, Baronio F, Tsiakas K, Murko S, Spiekerkoetter U, Santer R., Free PMC Article | 02/12/2022 |
| Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems. | Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
Schmidl S, Ursu O, Iancu CV, Oreb M, Oprea TI, Choe JY., Free PMC Article | 11/6/2021 |
| Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant beta cells. | Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
Low BSJ, Lim CS, Ding SSL, Tan YS, Ng NHJ, Krishnan VG, Ang SF, Neo CWY, Verma CS, Hoon S, Lim SC, Tai ES, Teo AKK., Free PMC Article | 06/19/2021 |
| The top cis-eQTL in liver tissue for SLC2A2 is the variant rs8192675, which displays a significant genetic association with metformin-induced HbA1c levels. The C allele at rs8192675 is associated with reduced SLC2A2, as demonstrated by reporter assays. | Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER, Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER., Free PMC Articles: PMC5007158, PMC5007158 | 06/14/2021 |
| O(6)-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms. | O(6)-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms.
Watanabe H, Yamazaki Y, Fujishima F, Izumi K, Imamura M, Hijioka S, Toriyama K, Yatabe Y, Kudo A, Motoi F, Unno M, Sasano H., Free PMC Article | 05/1/2021 |
| Insulinoma induces a hyperinsulinemia-mediated decrease of GLUT2 and GLP1 receptor in normal pancreatic beta-cells. | Insulinoma induces a hyperinsulinemia-mediated decrease of GLUT2 and GLP1 receptor in normal pancreatic β-cells.
Sho H, Fukui K, Yoneda S, Toyoda S, Ozawa H, Ishibashi C, Fujita Y, Eguchi H, Kozawa J, Shimomura I. | 04/17/2021 |
| Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance. | Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance.
Lei Y, Hu Q, Gu J., Free PMC Article | 03/27/2021 |
| Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models. | Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models.
Keshishian M, Akbari H, Khalighinejad B, Herrero JL, Mehta AD, Mesgarani N., Free PMC Article | 02/20/2021 |
| Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes. | Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes.
Bolla AM, Butera E, Pellegrini S, Caretto A, Bonfanti R, Zuppardo RA, Barera G, Cavestro GM, Sordi V, Bosi E. | 12/12/2020 |
| A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion. | A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion.
Alhaidan Y, Christesen HT, Højlund K, Al Balwi MA, Brusgaard K. | 08/13/2020 |
| SLC2A2 splice site variant is associated with autosomal recessive Fanconi-Bickel syndrome. | Genetic testing of two Pakistani patients affected with rare autosomal recessive Fanconi-Bickel syndrome and identification of a novel SLC2A2 splice site variant.
Batool H, Zubaida B, Hashmi MA, Naeem M. | 04/18/2020 |
| Data report for the first time that the in-frame deletion variant, p.Leu153_Ile154- del, has residual glucose uptake in patients with Fanconi-Bickel syndrome. In contrast, the majority of the five SLC2A2 missense variants associated with metabolic traits have normal glucose uptake and are expressed on the plasma membrane. Structural analysis revealed that variants affect substrate-binding, steric hindrance, or structure. | Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM., Free PMC Article | 03/21/2020 |
| The variant rs8192675 in the SLC2A2 gene (C allele) is associated with an improved glucose response to metformin monotherapy during the first year after diagnosis in type 2 diabetes. | A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes.
Rathmann W, Strassburger K, Bongaerts B, Kuss O, Müssig K, Burkart V, Szendroedi J, Kotzka J, Knebel B, Al-Hasani H, Roden M, GDS Group. | 06/29/2019 |
| High GLUT2 levels were detected in all cell lines. | Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia.
Hamann I, Krys D, Glubrecht D, Bouvet V, Marshall A, Vos L, Mackey JR, Wuest M, Wuest F. | 03/16/2019 |
| SGLT1, SGLT2 and GLUT2 have roles in renal glucose handling [review] | Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
Ghezzi C, Loo DDF, Wright EM., Free PMC Article | 02/2/2019 |
| Data suggest that the following genetic modifications are involved in neonatal diabetes mellitus patients in Oman: (1) mutation in KCNJ11 (potassium voltage-gated channel subfamily J member 11; one patient); (2) mutation in GCK (glucokinase); (3) mutation in SLC2A2 (glucose transporter type 2); (4) chromosome 6q24 methylation abnormalities. | Genetic mutations associated with neonatal diabetes mellitus in Omani patients.
Al Senani A, Hamza N, Al Azkawi H, Al Kharusi M, Al Sukaiti N, Al Badi M, Al Yahyai M, Johnson M, De Franco E, Flanagan S, Hattersley A, Ellard S, Mula-Abed WA., Free PMC Article | 09/8/2018 |
| Results showed the glucose transporter GLUT2 was highly expressed in the lumen of sweat glands from atopic dermatitis (AD) patients. AD patients with chronic inflammation had significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. | Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.
Ono E, Murota H, Mori Y, Yoshioka Y, Nomura Y, Munetsugu T, Yokozeki H, Katayama I., Free PMC Article | 07/28/2018 |
| Data suggest expression of SGLT1 is markedly increased in kidney of patients with type 2 diabetes as compared to control subjects; SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, data suggest SGLT2 and GLUT2 mRNA in kidney are down-regulated in type 2 diabetes, but not to statistically significant level. (SGLT = sodium-glucose co-transporter) | Sodium-glucose co-transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects.
Norton L, Shannon CE, Fourcaudot M, Hu C, Wang N, Ren W, Song J, Abdul-Ghani M, DeFronzo RA, Ren J, Jia W. | 05/12/2018 |
| The levels of GLUT1 and GLUT3, the major brain glucose transporters, are decreased, especially in the cerebral cortex in patient with Alzheimer disease. | Glucose Transporters in Brain: In Health and in Alzheimer's Disease.
Szablewski L. | 02/24/2018 |
| The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 | ANGPTL4 T266M variant is associated with reduced cancer invasiveness.
Tan ZW, Teo Z, Tan C, Choo CC, Loo WS, Song Y, Tam ZY, Ng SP, Koh HZ, Ng YS, Shochat SG, Yau YH, Zhu P, Tan NS. | 12/9/2017 |
| Single nucleotide polymorphism in SLC2A2 gene is associated with glycemic response to metformin in Type 2 diabetes. | Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER, Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER., Free PMC Articles: PMC5007158, PMC5007158 | 09/9/2017 |
| no significant associations between GLUT2 and/or TAS1R2 polymorphisms and fillings were found, but allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 and TASR1 polymorphisms may influence the risk of caries in the Czech population | GLUT2 and TAS1R2 Polymorphisms and Susceptibility to Dental Caries.
Izakovicova Holla L, Borilova Linhartova P, Lucanova S, Kastovsky J, Musilova K, Bartosova M, Kukletova M, Kukla L, Dusek L. | 12/24/2016 |