| three critical amino acid residues of N. crassa NCS-1 and its functional conservation across species using the orthologue from R. norvegicus | Identification of critical amino acid residues and functional conservation of the Neurospora crassa and Rattus norvegicus orthologues of neuronal calcium sensor-1.
Gohain D, Deka R, Tamuli R. | 02/18/2017 |
| In the Ca(2+)/NCS-1.D2R peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whereas in the GRK1 peptide complex it forms an a-helix | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.
Pandalaneni S, Karuppiah V, Saleem M, Haynes LP, Burgoyne RD, Mayans O, Derrick JP, Lian LY., Free PMC Article | 10/24/2015 |
| NCS-1 was decreased in prefrontal cortex 48 hours after sepsis induction | Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis.
Comim CM, Silva NC, Mina F, Dominguini D, Scaini G, Morais MO, Rosa DV, Magno LA, Streck EL, Romano-Silva MA, Quevedo J, Dal-Pizzol F. | 05/16/2015 |
| physical exercise could be modulating NCS-1 in an activity dependent manner, for specific neural substrates | Differential effects of swimming training on neuronal calcium sensor-1 expression in rat hippocampus/cortex and in object recognition memory tasks.
Drumond LE, Mourão FA, Leite HR, Abreu RV, Reis HJ, Moraes MF, Pereira GS, Massensini AR. | 10/27/2012 |
| NCS-1 modulates PKA/cAMP signaling pathway. | Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1.
Souza BR, Torres KC, Miranda DM, Motta BS, Caetano FS, Rosa DV, Souza RP, Giovani A Jr, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA. | 05/21/2011 |
| characterized individual residues in both non-myristoylated and myristoylated NCS-1 that access alternate states by measuring nonlinear temperature dependence of the backbone amide-proton ((1)H(N)) chemical shifts | Characterization of low-energy excited states in the native state ensemble of non-myristoylated and myristoylated neuronal calcium sensor-1.
Chandra K, Sharma Y, Chary KV. | 03/19/2011 |
| findings demonstrate that increasing the levels of intracellular NCS1 in injured and uninjured central neurons enhances their intrinsic anatomical plasticity within the injured adult central nervous system | Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat.
Yip PK, Wong LF, Sears TA, Yáñez-Muñoz RJ, McMahon SB., Free PMC Article | 10/23/2010 |
| Data show that overexpression of NCS-1 in PC12 cells induces an enhancement of intracellular second messenger and transmitter release dependent on CCH response, suggesting that muscarinic signaling is "up-regulated" in this cell model. | Modulation of muscarinic signaling in PC12 cells overexpressing neuronal Ca2+ sensor-1 protein.
Guimarães MM, Reis HJ, Guimarães LP, Carneiro DS, Ribeiro FM, Gomez MV, Jeromin A, Romano-Silva MA. | 01/21/2010 |
| These data demonstrate a role for NCS-1 and dopamine type-2 receptor in dentate gyrus (DG) plasticity and provide insight for understanding how the DG contributes to the origin of exploration and spatial memory acquisition | NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory.
Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC. | 01/21/2010 |
| This study demonstrates the importance of Mg(2+) as a modulator of calcium homeostasis and active-state behavior of NCS-1. | Regulatory and structural EF-hand motifs of neuronal calcium sensor-1: Mg 2+ modulates Ca 2+ binding, Ca 2+ -induced conformational changes, and equilibrium unfolding transitions.
Aravind P, Chandra K, Reddy PP, Jeromin A, Chary KV, Sharma Y. | 01/21/2010 |
| This protein and 1-phosphatidylinositol 4-kinase interact in neuronal cells and are translocated to membranes during exocytosis. | Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
Taverna E, Francolini M, Jeromin A, Hilfiker S, Roder J, Rosa P. | 01/21/2010 |
| functional implication of a NCS-1.PI4K-beta complex in regulated exocytosis in neurons | Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells.
de Barry J, Janoshazi A, Dupont JL, Procksch O, Chasserot-Golaz S, Jeromin A, Vitale N. | 01/21/2010 |
| These results demonstrate a novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells. | Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment.
Kapp-Barnea Y, Ninio-Many L, Hirschberg K, Fukuda M, Jeromin A, Sagi-Eisenberg R., Free PMC Article | 01/21/2010 |
| NCS-1 enhances exocytosis of secretory organelles in PC12 cells; NCS-1 interacts with putative targets on the plasma membrane and on secretory vesicles. | Neuronal calcium sensor-1 binds to regulated secretory organelles and functions in basal and stimulated exocytosis in PC12 cells.
Scalettar BA, Rosa P, Taverna E, Francolini M, Tsuboi T, Terakawa S, Koizumi S, Roder J, Jeromin A. | 01/21/2010 |
| metabotropic glutamate receptors at concentrations which induce synaptic plasticity regulate the expression of the immediate early gene arg3.1/arc, NCS-1 and VILIP-1 in different time frames and thus contribute to late phases of synaptic plasticity | MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo.
Brackmann M, Zhao C, Kuhl D, Manahan-Vaughan D, Braunewell KH. | 01/21/2010 |
| NCS-1 is involved in the control of regulated exocytosis in nonneural cells, where it contributes to stimulus-secretion coupling by interacting with phosphatidylinositol 4-kinase beta (PI4Kbeta)and positive regulation of its activity. | Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.
Kapp-Barnea Y, Melnikov S, Shefler I, Jeromin A, Sagi-Eisenberg R. | 01/21/2010 |
| These results support the idea that NCS-1 facilitates nerve ending neurotransmitter release and phosphoinositide production via PI-4 Kinase and localizes these effects to the N-terminal of NCS-1. | Neuronal calcium sensor-1 facilitates neuronal exocytosis through phosphatidylinositol 4-kinase.
Zheng Q, Bobich JA, Vidugiriene J, McFadden SC, Thomas F, Roder J, Jeromin A. | 01/21/2010 |
| The selective loss of NCS-1 during colitis may underlie the altered neural function seen in the inflamed intestine. | Intestinal inflammation modulates expression of the synaptic vesicle protein neuronal calcium sensor-1.
Lourenssen S, Jeromin A, Roder J, Blennerhassett MG. | 01/21/2010 |
| Phosphatidylinositol 4-OH kinase is a downstream target of this protein in enhancing exocytosis in neuroendocrine cells | Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.
Rajebhosale M, Greenwood S, Vidugiriene J, Jeromin A, Hilfiker S. | 01/21/2010 |
| mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells | Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells.
Koizumi S, Rosa P, Willars GB, Challiss RA, Taverna E, Francolini M, Bootman MD, Lipp P, Inoue K, Roder J, Jeromin A. | 01/21/2010 |
| Analysis with chimeric proteins between KChIP2 and NCS-1 reveals that the three regions of KChIP2 are necessary and sufficient for its effective binding to Kv4.3 protein | Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide.
Ren X, Shand SH, Takimoto K. | 01/21/2010 |
| NCS-1 is a novel survival-promoting factor up-regulated in injured neurons that mediates the GDNF survival signal via the phosphatidylinositol 3-kinase-Akt pathway. | Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons.
Nakamura TY, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, Wakabayashi S, Nabekura J., Free PMC Article | 01/21/2010 |
| The results of this study suggest that NCS-1 is involved in the formation and function of presynaptic nerve terminal part of the neuromuscular junction during synaptogenesis and in adult mammals. | Localization of neuronal calcium sensor-1 at the adult and developing rat neuromuscular junction.
Garcia N, Lanuza MA, Besalduch N, Santafe MM, Jeromin A, Tomas J. | 01/21/2010 |
| Increases in the calcium binding protein neuronal calcium sensor-1 (NCS-1) can switch paired-pulse depression to facilitation without altering basal synaptic transmission or initial neurotransmitter release probability. | Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1.
Sippy T, Cruz-Martín A, Jeromin A, Schweizer FE., Free PMC Article | 01/21/2010 |
| The data suggest protein-protein interaction between NCS-1 and TRPC5, and involvement of this protein complex in retardation of neurite outgrowth. | Calcium-sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth.
Hui H, McHugh D, Hannan M, Zeng F, Xu SZ, Khan SU, Levenson R, Beech DJ, Weiss JL., Free PMC Article | 01/21/2010 |