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    XAGE1A X antigen family member 1A [ Homo sapiens (human) ]

    Gene ID: 653220, updated on 5-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia.

    Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia.
    Skou AS, Juul-Dam KL, Hansen M, Lausen B, Stratmann S, Holmfeldt L, Aggerholm A, Nyvold CG, Ommen HB, Hasle H.

    03/12/2022
    High XAGE1 expression is associated with metastasis in Head and Neck Squamous Cell Carcinoma.

    Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma.
    Karia BTR, Zamuner FT, Carlin V, de Oliveira CZ, Carvalho AL, Vettore AL.

    06/15/2019
    In patients with Colon cancer, the expression of XAGE-1 gene was related to a favorable prognosis.

    [Cancer-testis genes in colon cancer].
    Hilal NR, Novikov DV, Novikov VV, Karaulov AV.

    09/2/2017
    Strong immune responses to the cancer testis antigen XAGE-1b have been found in non-small cell lung cancer Caucasian patients.

    Immune Responses to the Cancer Testis Antigen XAGE-1b in Non Small Cell Lung Cancer Caucasian Patients.
    Saito K, Nakayama E, Valmori D., Free PMC Article

    08/6/2016
    Data indicate the involvement of immunoglobulin allotypes immunoglobulin gamma and kappa chains in immunity to a cancer-testis antigen, which has important implications for XAGE-1b-based immunotherapeutic interventions in lung adenocarcinoma.

    Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.
    Pandey JP, Namboodiri AM, Ohue Y, Oka M, Nakayama E., Free PMC Article

    05/3/2014
    Our results suggest that GAGE, XAGE1 and SSX4 might each have a role in melanoma progression

    Effects of CT-Xp gene knock down in melanoma cell lines.
    Caballero OL, Cohen T, Gurung S, Chua R, Lee P, Chen YT, Jat P, Simpson AJ., Free PMC Article

    04/15/2014
    the XAGE-1b gene was expressed at the mRNA level in a proportion of human acute leukemia

    mRNA expression of the XAGE-1 gene in human acute leukemia.
    Ji Y, Zhang W, Wang J, Gu L.

    04/15/2014
    XAGE-1b gene was able to influence angiogenesis directly or indirectly, leading to tumorigenesis and metastasis of ACC.

    Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression.
    Zhou B, Li T, Liu Y, Zhu N.

    04/12/2014
    The findings suggest that XAGE-1b and HLA class I expression elicited a CD8+ T-cell response against minimal residual disease after surgery and resulted in prolonged survival of non-small cell lung cancer patients.

    Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
    Kikuchi E, Yamazaki K, Nakayama E, Sato S, Uenaka A, Yamada N, Oizumi S, Dosaka-Akita H, Nishimura M., Free PMC Article

    01/21/2010
    A 12-mer peptide XAGE-1b(37-48) as a new XAGE-1b epitope restricted to HLA-DRB1*0410 was identified.

    HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells.
    Morishita Y, Uenaka A, Kaya S, Sato S, Aji T, Nakayama E.

    01/21/2010
    Recognition of XAGE-1b on OU-LU-6 tumor by the CD4-expressing tumor-infiltrating lymphocytes was studied.

    Identification of DR9-restricted XAGE antigen on lung adenocarcinoma recognized by autologous CD4 T-cells.
    Shimono M, Uenaka A, Noguchi Y, Sato S, Okumura H, Nakagawa K, Kiura K, Tanimoto M, Nakayama E.

    01/21/2010
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