| Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis. | Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.
Meadows V, Marakovits C, Ekser B, Kundu D, Zhou T, Kyritsi K, Pham L, Chen L, Kennedy L, Ceci L, Wu N, Carpino G, Zhang W, Isidan A, Meyer A, Owen T, Gaudio E, Onori P, Alpini G, Francis H., Free PMC Article | 01/7/2023 |
| Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy. | Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
Ontsouka E, Epstein A, Kallol S, Zaugg J, Baumann M, Schneider H, Albrecht C., Free PMC Article | 10/30/2021 |
| A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT. | A Novel Fluorescence-Based Method to Evaluate Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT.
Zhu Q, Komori H, Imamura R, Tamai I. | 07/24/2021 |
| S-acylation status of bile acid transporter hASBT regulates its function, metabolic stability, membrane expression, and phosphorylation state. | S-acylation status of bile acid transporter hASBT regulates its function, metabolic stability, membrane expression, and phosphorylation state.
Ayewoh EN, Czuba LC, Nguyen TT, Swaan PW. | 04/17/2021 |
| Efficient SNP editing in haploid human pluripotent stem cells. | Efficient SNP editing in haploid human pluripotent stem cells.
Safier LZ, Zuccaro MV, Egli D., Free PMC Article | 01/16/2021 |
| S-acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells. | S-acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells.
Ticho AL, Malhotra P, Manzella CR, Dudeja PK, Saksena S, Gill RK, Alrefai WA., Free PMC Article | 01/2/2021 |
| Results found that, in obesity, intestinal bile acid absorption is increased secondary to increased expression of apical bile acid cotransporter, ASBT, in the brush border membrane of villus cells. The mechanism of stimulation of ASBT expression is likely secondary to increased expression of FXR in these cells. | Mechanism of Dyslipidemia in Obesity-Unique Regulation of Ileal Villus Cell Brush Border Membrane Sodium-Bile Acid Cotransport.
Sundaram S, Palaniappan B, Nepal N, Chaffins S, Sundaram U, Arthur S., Free PMC Article | 07/18/2020 |
| Study data confirms that tyrosine phosphorylation mediated by Src family kinases (SFKs), in particular, regulates surface expression, function, and stability of hASBT. | Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2).
Chothe PP, Czuba LC, Ayewoh EN, Swaan PW. | 06/27/2020 |
| A cysteine-less form of hASBT was made by creating point mutations at all 13 endogenous cysteines. Cysless hASBT had significantly reduced function correlated with lowered surface expression.Chemical cross-linking of wild-type and Cysless species revealed that hASBT has a dominant negative effect and exists as an active dimer and/or higher order oligomer with apparently no requirement for endogenous cysteine residues. | Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers.
Chothe PP, Czuba LC, Moore RH, Swaan PW., Free PMC Article | 05/19/2018 |
| Two single-nucleotide polymorphisms at novel loci, rs112404845 (P = 3.8 x 10-8), upstream of COBL, and rs16961023 (P = 4.6 x 10-8), downstream of SLC10A2, obtained genome-wide significant evidence of association with the posterior liability of late-onset Alzheimer's disease in African Americans. | Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.
Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ, Alzheimer's Disease Genetics Consortium, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA., Free PMC Article | 12/9/2017 |
| Data (including data from studies in knockout/transgenic mice) suggest that SLC10A2 is a functional receptor for hepatitis D virus in hepatocytes. | Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide.
He W, Ren B, Mao F, Jing Z, Li Y, Liu Y, Peng B, Yan H, Qi Y, Sun Y, Guo JT, Sui J, Wang F, Li W., Free PMC Article | 04/2/2016 |
| Results unravel novel roles for N-glycosylation of ASBT and suggest that high levels of glucose alter the composition of the glycan and may contribute to the increase in ASBT function in diabetes mellitus. | N-glycosylation is essential for ileal ASBT function and protection against proteases.
Muthusamy S, Malhotra P, Hosameddin M, Dudeja AK, Borthakur S, Saksena S, Gill RK, Dudeja PK, Alrefai WA., Free PMC Article | 08/29/2015 |
| The p.Ser267Phe NTCP variant is significantly associated with resistance to chronic hepatitis B and a lower incidence of acute-on-chronic liver failure. Our results support that NTCP is a cellular receptor for HBV in human infection | The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.
Peng L, Zhao Q, Li Q, Li M, Li C, Xu T, Jing X, Zhu X, Wang Y, Li F, Liu R, Zhong C, Pan Q, Zeng B, Liao Q, Hu B, Hu ZX, Huang YS, Sham P, Liu J, Xu S, Wang J, Gao ZL, Wang Y. | 06/6/2015 |
| Data indicate that the lipid flippase (ATP8B1)-transmembrane protein 30A (CDC50A) heterodimer is essential for the apical localization of sodium-dependent bile acid transporter (SLC10A2/ASBT) in Caco-2 cells. | The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.
van der Mark VA, de Waart DR, Ho-Mok KS, Tabbers MM, Voogt HW, Oude Elferink RP, Knisely AS, Paulusma CC. | 05/2/2015 |
| It was conclude that regulation of ASBT expression by resveratrol (RSV) may have clinical relevance with regard to the observed cholesterol-lowering effects of RSV. | Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).
Chothe PP, Swaan PW. | 05/31/2014 |
| Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation. | Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation.
Sabit H, Mallajosyula SS, MacKerell AD Jr, Swaan PW., Free PMC Article | 01/25/2014 |
| ASBT evolved from the earliest vertebrates by gaining affinity for modern bile salts while retaining affinity for older bile salts | Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2).
Lionarons DA, Boyer JL, Cai SY., Free PMC Article | 11/24/2012 |
| This study provided novel evidence for the alterations in the activity of ASBT by enteropathogenic Escherichia coli infection. | Enteropathogenic Escherichia coli inhibits ileal sodium-dependent bile acid transporter ASBT.
Annaba F, Sarwar Z, Gill RK, Ghosh A, Saksena S, Borthakur A, Hecht GA, Dudeja PK, Alrefai WA., Free PMC Article | 07/21/2012 |
| There was no significant association of rs9514089 with gallstone risk, serum lipid parameters and BMI in the Sorbs and in the meta-analysis of all three cohorts. [meta-analysis] | Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts.
Tönjes A, Wittenburg H, Halbritter J, Renner O, Harsch S, Stange EF, Lammert F, Stumvoll M, Kovacs P., Free PMC Article | 03/10/2012 |
| Presence of multiple functionally relevant variants in SLC10A2 that may influence bile acid homeostasis and physiology. | Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2).
Ho RH, Leake BF, Urquhart BL, Gregor JC, Dawson PA, Kim RB., Free PMC Article | 03/10/2012 |
| The human ASBT promoter was activated transcriptionally by CDX1 and CDX2. | Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2.
Ma L, Jüttner M, Kullak-Ublick GA, Eloranta JJ. | 02/18/2012 |
| The beneficial effect of rifampicin in cholestasis is associated with an increase in DME expression involved in toxic, bile acid and cholesterol metabolism, as well as a reduction in the bile acid importing system in hepatocytes. | Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids.
González R, Cruz A, Ferrín G, López-Cillero P, Briceño J, Gómez MA, Rufián S, Padillo J, De la Mata M, Marin JJ, Muntané J. | 12/17/2011 |
| data demonstrate that TM1 plays a pivotal role in ASBT function and stability, thereby providing further insight in its dynamic transport mechanism | Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.
da Silva TC, Hussainzada N, Khantwal CM, Polli JE, Swaan PW., Free PMC Article | 10/15/2011 |
| the essential role of ASBT in the uptake of bile acids, by which the enterohepatic recirculation of bile acids is maintained | Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.
Pan W, Song IS, Shin HJ, Kim MH, Choi YL, Lim SJ, Kim WY, Lee SS, Shin JG. | 10/1/2011 |
| Results show that bile acid conjugates are potential prolonged release prodrugs with binding affinity for ASBT. | Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT.
Zheng X, Polli JE., Free PMC Article | 11/6/2010 |