| OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids. | OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids.
Mickols E, Meyer A, Handin N, Stüwe M, Eriksson J, Rudfeldt J, Blom K, Fryknäs M, Sellin ME, Lauschke VM, Karlgren M, Artursson P., Free PMC Article | 09/3/2024 |
| The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics. | The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
Yee SW, Macdonald CB, Mitrovic D, Zhou X, Koleske ML, Yang J, Buitrago Silva D, Rockefeller Grimes P, Trinidad DD, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W., | 08/16/2024 |
| THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma. | THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma.
Yu S, Cui X, Zhou S, Li Y, Feng W, Zhang X, Zhong Y, Zhang P., Free PMC Article | 04/29/2024 |
| Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. | Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Zeng YC, Sobti M, Quinn A, Smith NJ, Brown SHJ, Vandenberg JI, Ryan RM, O'Mara ML, Stewart AG., Free PMC Article | 11/3/2023 |
| Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing metformin monotherapy. | Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing metformin monotherapy.
Singh S, Shukla AK, Usman K, Banerjee M. | 03/9/2023 |
| The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region. | The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region.
Fernandes SSM, Leitão LPC, Cohen-Paes AN, Gellen LPA, Pastana LF, de Carvalho DC, Modesto AAC, da Costa ACA, Wanderley AV, Lima CHV, Pereira EEB, Fernandes MR, Burbano RMR, de Assumpção PP, Santos SEBD, Santos NPCD., Free PMC Article | 07/30/2022 |
| Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. | Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.
Meyer MJ, Schreier PCF, Basaran M, Vlasova S, Seitz T, Brockmöller J, Zdrazil B, Tzvetkov MV., Free PMC Article | 07/2/2022 |
| Association of SLC22A1,SLCO1B3 Drug Transporter Polymorphisms and Smoking with Disease Risk and Cytogenetic Response to Imatinib in Patients with Chronic Myeloid Leukemia. | Association of SLC22A1,SLCO1B3 Drug Transporter Polymorphisms and Smoking with Disease Risk and Cytogenetic Response to Imatinib in Patients with Chronic Myeloid Leukemia.
Mohammadi F, Rostami G, Assad D, Shafiei M, Hamid M, Jalaeikhoo H. | 04/30/2022 |
| Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women. | Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women.
Cahua-Pablo JÁ, Gómez-Zamudio JH, Reséndiz-Abarca CA, Tello-Flores VA, Eulogio-Metodio Y, Ramírez-Vargas MA, Cruz M, Del Carmen Alarcón-Romero L, Matia-García I, Marino-Ortega LA, Zubillaga-Guerrero MI, Flores-Alfaro E. | 04/30/2022 |
| OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer. | OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer.
Obinata D, Funakoshi D, Takayama K, Hara M, Niranjan B, Teng L, Lawrence MG, Taylor RA, Risbridger GP, Suzuki Y, Takahashi S, Inoue S., Free PMC Article | 04/30/2022 |
| Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1. | Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1.
Jensen O, Gebauer L, Brockmöller J, Dücker C., Free PMC Article | 03/19/2022 |
| Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M. | 03/5/2022 |
| Comprehensive in-silico analysis of damage associated SNPs in hOCT1 affecting Imatinib response in chronic myeloid leukemia. | Comprehensive in-silico analysis of damage associated SNPs in hOCT1 affecting Imatinib response in chronic myeloid leukemia.
Soltani I, Bahia W, Radhouani A, Mahdhi A, Ferchichi S, Almawi WY. | 02/26/2022 |
| Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes. | Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes.
Chen P, Cao Y, Guo Y, Xu Q, Wang X, Zhang L, Liu Z, Chen D, Chen S, Chen S. | 01/22/2022 |
| [Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer]. | [Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].
Zhang YY, Cao J, Chen XT, Chen JH, Zheng YB. | 09/4/2021 |
| Overexpression of OCT-1 gene is a biomarker of adverse prognosis for diffuse large B-cell lymphoma (DLBCL): data from a retrospective cohort of 77 Brazilian patients. | Overexpression of OCT-1 gene is a biomarker of adverse prognosis for diffuse large B-cell lymphoma (DLBCL): data from a retrospective cohort of 77 Brazilian patients.
Gouveia GR, Ferreira SC, Siqueira SAC, de Pádua Covas Lage LA, Hallack Neto AE, de Oliveira Costa R, Pereira J., Free PMC Article | 05/15/2021 |
| Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy. | Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.
Rumiato E, Boldrin E, Malacrida S, Battaglia G, Sileni VC, Ruol A, Amadori A, Saggioro D. | 04/3/2021 |
| Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction. | Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
Floerl S, Kuehne A, Hagos Y., Free PMC Article | 02/27/2021 |
| DLX6-AS1/miR-204-5p/OCT1 positive feedback loop promotes tumor progression and epithelial-mesenchymal transition in gastric cancer. | DLX6-AS1/miR-204-5p/OCT1 positive feedback loop promotes tumor progression and epithelial-mesenchymal transition in gastric cancer.
Liang Y, Zhang CD, Zhang C, Dai DQ. | 02/6/2021 |
| Relationship between changes in the exon-recognition machinery and SLC22A1 alternative splicing in hepatocellular carcinoma. | Relationship between changes in the exon-recognition machinery and SLC22A1 alternative splicing in hepatocellular carcinoma.
Soto M, Reviejo M, Al-Abdulla R, Romero MR, Macias RIR, Boix L, Bruix J, Serrano MA, Marin JJG. | 10/31/2020 |
| Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study. | Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study.
Reséndiz-Abarca CA, Flores-Alfaro E, Suárez-Sánchez F, Cruz M, Valladares-Salgado A, Del Carmen Alarcón-Romero L, Vázquez-Moreno MA, Wacher-Rodarte NA, Gómez-Zamudio JH. | 08/15/2020 |
| Characterized the potential interactome of hOCT1 and 2. | Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.
Snieder B, Brast S, Grabner A, Buchholz S, Schröter R, Spoden GA, Florin L, Salomon J, Albrecht T, Barz V, Sparreboom A, Ciarimboli G. | 05/23/2020 |
| Use of a genetic risk score derived from rs3889348 and SLC22A1 variants found that the odds of metformin gastrointestinal intolerance were more than twice as high in individuals who carry three or more risk alleles compared with those carrying none (OR 2.15, P = 0.01). | Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.
Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJM, Rauh SP, Jones AG, Holl RW, Stingl JC, Franks PW, McCarthy MI, 't Hart LM, Pearson ER, IMI DIRECT Consortium. | 03/28/2020 |
| The study explored the association between polymorphisms and acitretin efficacy in psoriasis vulgaris patients. The polymorphisms rs4149056 in the SLCO1B1 gene and rs2282143 in the SLC22A1 gene were associated with efficacy, both in the discovery (P = 0.013 and P = 0.002) and validation phases (P = 0.028 and P = 0.014), based on a 50% reduction from before to after treatment of the psoriasis area severity index (PASI50). | Polymorphisms of SLCO1B1 rs4149056 and SLC22A1 rs2282143 are associated with responsiveness to acitretin in psoriasis patients.
Chen W, Zhang X, Zhang W, Peng C, Zhu W, Chen X., Free PMC Article | 11/9/2019 |
| SLC22A1 gene polymorphisms rs628031 and rs2282143 are | Relationship Between SLC22A1 and SLC22A4 Gene Polymorphisms and Risk of Type 2 Diabetes in Chinese Han Population.
Long G, Zhang G, Zhang F, Ye D, Yang D, Yang Y. | 09/21/2019 |