| A Polynesian-specific SLC22A3 variant associates with low plasma lipoprotein(a) concentrations independent of apo(a) isoform size in males. | A Polynesian-specific SLC22A3 variant associates with low plasma lipoprotein(a) concentrations independent of apo(a) isoform size in males.
Wang Q, McCormick S, Leask MP, Watson H, O'Sullivan C, Krebs JD, Hall R, Whitfield P, Merry TL, Murphy R, Shepherd PR. | 07/18/2024 |
| Targeted mutagenesis of negatively charged amino acids outlining the substrate translocation path within the human organic cation transporter 3. | Targeted mutagenesis of negatively charged amino acids outlining the substrate translocation path within the human organic cation transporter 3.
Redeker KM, Schröder S, Dücker C, Brockmöller J, Gebauer L. | 04/25/2024 |
| LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene Polymorphisms Contribute to the Risk of Coronary Artery Disease in Chinese Han Population. | LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene Polymorphisms Contribute to the Risk of Coronary Artery Disease in Chinese Han Population.
Chen L, Zhao M, Zhou M, Luo J, Li S, Liu X, Cheng Z, Zhuo Y, Zeng W, Zhang Z, Zhou L. | 01/14/2024 |
| Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape. | Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape.
Pearce B, Jacobs C, Benjeddou M., Free PMC Article | 11/28/2023 |
| Repression of SLC22A3 by the AR-V7/YAP1/TAZ axis in enzalutamide-resistant castration-resistant prostate cancer. | Repression of SLC22A3 by the AR-V7/YAP1/TAZ axis in enzalutamide-resistant castration-resistant prostate cancer.
Seo E, Jee B, Chung JH, Song W, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Kang M. | 03/23/2023 |
| HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-kappaB signal pathway. | HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway.
Zhang J, Chang Y, Xia H, Xu L, Wei X. | 03/12/2022 |
| A Single Nucleotide Polymorphism (SNP) in the SLC22A3 Transporter Gene Is Associated With the Severity of Oral Mucositis in Multiple Myeloma Patients Receiving Autologous Stem Cell Transplant Followed by Melphalan Therapy. | A Single Nucleotide Polymorphism (SNP) in the SLC22A3 Transporter Gene Is Associated With the Severity of Oral Mucositis in Multiple Myeloma Patients Receiving Autologous Stem Cell Transplant Followed by Melphalan Therapy.
Li J, Persaud AK, Johnson JA, Sborov DW, Phelps MA, Hofmeister CC, Poi MJ. | 01/15/2022 |
| LncRNA AL592284.1 facilitates proliferation and metastasis of cervical cancer cells via miR-30a-5p/Vimentin/EMT axis. | LncRNA AL592284.1 facilitates proliferation and metastasis of cervical cancer cells via miR-30a-5p/Vimentin/EMT axis.
Zhang J, Liu HL, Liu JB, Zhang Y, Liu J, Li YH. | 11/27/2021 |
| Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta. | Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta.
Karahoda R, Horackova H, Kastner P, Matthios A, Cerveny L, Kucera R, Kacerovsky M, Duintjer Tebbens J, Bonnin A, Abad C, Staud F., Free PMC Article | 07/31/2021 |
| Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels in Human Skin. | Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels in Human Skin.
Takechi T, Hirota T, Fujii K, Nakahara T, Sakai T, Maeda N, Furue M, Ieiri I. | 07/3/2021 |
| Protein expression of ABCC2 and SLC22A3 associates with prognosis of pancreatic adenocarcinoma. | Protein expression of ABCC2 and SLC22A3 associates with prognosis of pancreatic adenocarcinoma.
Cervenkova L, Vycital O, Bruha J, Rosendorf J, Palek R, Liska V, Daum O, Mohelnikova-Duchonova B, Soucek P., Free PMC Article | 11/21/2020 |
| The cytoplasmic dsRNA increased OCT3 mRNA, cytoplasmic dsDNAs, such as salmon sperm DNA and poly(dA:dT), did not. Interestingly, the expression of NANOG, SOX2, Kruppel-like factor 4 (KLF4), and proto-oncogene c-Myc was also increased by cytoplasmic dsRNA. | Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells.
Wang G, Kouwaki T, Mugikura K, Okamoto M, Takaki H, Funami K, Seya T, Oshiumi H., Free PMC Article | 07/18/2020 |
| Heterologous PITX2 expression induced ABCB1, repressed hOCT3/SLC22A3, enhanced vincristine resistance and diminished proliferation inhibition in colonic and kidney tumor cells. | Oncogenic PITX2 facilitates tumor cell drug resistance by inverse regulation of hOCT3/SLC22A3 and ABC drug transporters in colon and kidney cancers.
Lee WK, Thévenod F. | 02/8/2020 |
| Data suggest that an organic cation transporter 3 (OCT3) promoter haplotype affects the pharmacokinetics of metformin in Koreans as well as the OCT3 transcription rate. | OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans.
Kwon EY, Chung JY, Park HJ, Kim BM, Kim M, Choi JH., Free PMC Article | 11/23/2019 |
| Expression of SLC22A3 was significantly higher in colorectal cancer tissues than that in paired normal tissues. The phenotypes of proliferation, migration, invasion, cell cycle and apoptosis of colorectal cancer cell were significantly affected by SLC22A3 in vitro. Results revealed a novel susceptible locus, rs420038 in SLC22A3, which may be involved in colorectal cancer development and progression. | Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer.
Ren A, Sun S, Li S, Chen T, Shu Y, Du M, Zhu L., Free PMC Article | 11/2/2019 |
| Study show that epigenetic alterations of SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer. | Epigenetic alterations of a novel antioxidant gene SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer.
Xiong JX, Wang YS, Sheng J, Xiang D, Huang TX, Tan BB, Zeng CM, Li HH, Yang J, Meltzer SJ, Mori Y, Qin YR, Guan XY, Fu L., Free PMC Article | 09/14/2019 |
| The rs3088442 G>A variant of SLC22A3 acts as a protective allele and is associated with the clinical response to metformin. Overexpression of microRNA 147 is associated with a downward expression of the SLC22A3 gene in patients who have type 2 diabetes. | Evaluation of the rs3088442 G>A SLC22A3 Gene Polymorphism and the Role of microRNA 147 in Groups of Adult Pakistani Populations With Type 2 Diabetes in Response to Metformin.
Moeez S, Riaz S, Masood N, Kanwal N, Arif MA, Niazi R, Khalid S. | 08/3/2019 |
| The rs2048327 single nucleotide polymorphism of the SLC22A3 gene was significantly associated with lipoprotein(a) as well as with cardiovascular disease events in familial hypercholesterolemia subjects | SLC22A3 is associated with lipoprotein (a) concentration and cardiovascular disease in familial hypercholesterolemia.
Paquette M, Bernard S, Baass A. | 04/27/2019 |
| Data show that the common variation in the solute carrier family 22 member 3 (SLC22A3) gene is unlikely to significantly contribute to pancreatic cancer risk, and the rs2504938 single nucleotide polymorphism (SNP) in SLC22A3 significantly associates with an unfavorable prognosis of pancreatic cancer patients. | SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival.
Mohelnikova-Duchonova B, Strouhal O, Hughes DJ, Holcatova I, Oliverius M, Kala Z, Campa D, Rizzato C, Canzian F, Pezzilli R, Talar-Wojnarowska R, Malecka-Panas E, Sperti C, Federico Zambon C, Pedrazzoli S, Fogar P, Milanetto AC, Capurso G, Delle Fave G, Valente R, Gazouli M, Malleo G, Teresa Lawlor R, Strobel O, Hackert T, Giese N, Vodicka P, Vodickova L, Landi S, Tavano F, Gioffreda D, Piepoli A, Pazienza V, Mambrini A, Pedata M, Cantore M, Bambi F, Ermini S, Funel N, Lemstrova R, Soucek P., Free PMC Article | 11/10/2018 |
| SNPs in SLC22A3 and H3F3B may influence lipid levels through altering the expression of local genes. | Putative functional SNPs in SLC22A3 and H3F3B might influence the development of CAD by regulating the lipid levels.
Mo X, Zhang H, Lei S, Xu T, Wang A, Guo Z, Zhang Y. | 11/3/2018 |
| A-to-I RNA editing of SLC22A3 contributes to the early development and progression of familial esophageal squamous cell carcinoma in high-risk individuals. | RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.
Fu L, Qin YR, Ming XY, Zuo XB, Diao YW, Zhang LY, Ai J, Liu BL, Huang TX, Cao TT, Tan BB, Xiang D, Zeng CM, Gong J, Zhang Q, Dong SS, Chen J, Liu H, Wu JL, Qi RZ, Xie D, Wang LD, Guan XY., Free PMC Article | 05/19/2018 |
| our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population. | PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population.
Zhao Q, Wei H, Liu D, Shi B, Li L, Yan M, Zhang X, Wang F, Ouyang Y., Free PMC Article | 03/10/2018 |
| SLC22A3 deletion is associated with motor speech disorders, and language delays. | Two unrelated children with overlapping 6q25.3 deletions, motor speech disorders, and language delays.
Peter B, Lancaster H, Vose C, Fares A, Schrauwen I, Huentelman M. | 02/10/2018 |
| may be a regulator of the concentration of norepinephrine in adipose tissue. | High expression of organic cation transporter 3 in human BAT-like adipocytes. Implications for extraneuronal norepinephrine uptake.
Breining P, Pedersen SB, Pikelis A, Rolighed L, Sundelin EIO, Jessen N, Richelsen B. | 11/25/2017 |
| the rs3088442G>A variant as a genetic marker may potentially assist in the identification of individuals at an increased risk of T2D. | Polymorphic Variants rs3088442 and rs2292334 in the Organic Cation Transporter 3 (OCT3) Gene and Susceptibility Against Type 2 Diabetes: Role of their Interaction.
Mahrooz A, Alizadeh A, Hashemi-Soteh MB, Ghaffari-Cherati M, Hosseyni-Talei SR. | 08/5/2017 |