| The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer. | The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer.
Chen J, Wang L, Tong G, Ma J, Liu C, Wang L. | 02/16/2023 |
| Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression. | Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression.
Abrahams-October Z, Lloyd S, Pearce B, Johnson R, Benjeddou M. | 03/26/2022 |
| Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells. | Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.
Zhang X, Wright SH., Free PMC Article | 03/19/2022 |
| Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives. | Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives.
Eltayeb SA, Ciarimboli G, Beul K, Seno Di Marco G, Barz V., Free PMC Article | 03/12/2022 |
| Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M. | 03/5/2022 |
| Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity. | Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity.
Lefèvre CR, Le Vée M, Gaubert S, Jouan E, Bruyere A, Moreau C, Fardel O., Free PMC Article | 01/15/2022 |
| Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model. | Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model.
Koepp TN, Tokaj A, Nedvetsky PI, Conchon Costa AC, Snieder B, Schröter R, Ciarimboli G., Free PMC Article | 10/30/2021 |
| Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy. | Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.
Abumiya M, Takahashi N, Takahashi S, Yoshioka T, Kameoka Y, Miura M., Free PMC Article | 10/16/2021 |
| Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. | Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.
Costa ACC, Yamamoto PA, Lauretti GR, de Lima Benzi JR, Zanelli CF, Barz V, Ciarimboli G, de Moraes NV. | 07/10/2021 |
| The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. | The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, Wang H, Zeng K, Liu J, Zeng S, Yu L., Free PMC Article | 04/13/2021 |
| Low HDL concentration in rs2048327-G carriers can predispose men to develop coronary heart disease: Tehran Cardiometabolic genetic study (TCGS). | Low HDL concentration in rs2048327-G carriers can predispose men to develop coronary heart disease: Tehran Cardiometabolic genetic study (TCGS).
Najd Hassan Bonab L, Moazzam-Jazi M, Miri Moosavi RS, Fallah MS, Lanjanian H, Masjoudi S, Daneshpour MS. | 03/27/2021 |
| Rosai-Dorfman Disease Displays a Unique Monocyte-Macrophage Phenotype Characterized by Expression of OCT2. | Rosai-Dorfman Disease Displays a Unique Monocyte-Macrophage Phenotype Characterized by Expression of OCT2.
Ravindran A, Goyal G, Go RS, Rech KL, Mayo Clinic Histiocytosis Working Group. | 02/2/2021 |
| Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects. | Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects.
Boof ML, Halabi A, Ufer M, Dingemanse J. | 11/21/2020 |
| Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2. | Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2.
Frenzel D, Köppen C, Bauer OB, Karst U, Schröter R, Tzvetkov MV, Ciarimboli G., Free PMC Article | 08/22/2020 |
| A variant of the OCT2-encoding gene, in addition to or in synergy with higher dolutegravir Ctrough, is associated with a set of NPs observed during dolutegravir therapy. | SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV.
Borghetti A, Calcagno A, Lombardi F, Cusato J, Belmonti S, D'Avolio A, Ciccarelli N, La Monica S, Colafigli M, Delle Donne V, De Marco R, Tamburrini E, Visconti E, Di Perri G, De Luca A, Bonora S, Di Giambenedetto S. | 06/27/2020 |
| In renal cell carcinoma (RCC) cells, the interaction between HDAC7 and MYC does not occur leading to a high abundance of HDAC7 and low levels of H3K18ac and H3K27ac at the OCT2 promoter, thereby resulting in the inhibition of OCT2 transcription. | Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma.
Zhu Q, Yu L, Qin Z, Chen L, Hu H, Zheng X, Zeng S., Free PMC Article | 05/30/2020 |
| Co-expression of hOCT2 and CD9 led to strong cell surface localization of the transporter. | Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.
Snieder B, Brast S, Grabner A, Buchholz S, Schröter R, Spoden GA, Florin L, Salomon J, Albrecht T, Barz V, Sparreboom A, Ciarimboli G. | 05/23/2020 |
| addition of allele A at SLC22A2 rs316019 was associated with increased risk (ORadj = 4.41; 95% CI: 1.96-9.88; p < 0.001) while genotype AC was associated with a higher risk of cisplatin nephrotoxicity (ORadj = 5.06; 95% CI: 1.69-15.16; p = 0.004) compared to genotype CC. | Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients.
Zazuli Z, Otten LS, Drögemöller BI, Medeiros M, Monzon JG, Wright GEB, Kollmannsberger CK, Bedard PL, Chen Z, Gelmon KA, McGoldrick N, Kitchlu A, Vijverberg SJH, Masereeuw R, Ross CJD, Liu G, Carleton BC, Maitland-van der Zee AH., Free PMC Article | 02/15/2020 |
| Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing | Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S., Free PMC Article | 01/4/2020 |
| African-specific promoter polymorphisms can cause a decrease in the SLC22A2 gene expression levels in vitro, which in turn, may influence the pharmacokinetic profiles of cationic drugs. | Effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels.
Pearce B, Abrahams-October Z, Xhakaza L, Jacobs C, Benjeddou M. | 12/22/2018 |
| OCT2-altered expression in primary and metastatic cancer cells. | Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.
Visentin M, Torozi A, Gai Z, Häusler S, Li C, Hiller C, Schraml PH, Moch H, Kullak-Ublick GA. | 11/17/2018 |
| Circ2174 has sequence complementarity to miR149 which can target Oct-2.These data suggest a mechanism whereby circ2174 can act as a sponge to regulate the expression of miR149, and thereby modulate Oct-2 and interleukin-16 signaling pathways in cholangiocarcinoma. | Network analyses-based identification of circular ribonucleic acid-related pathways in intrahepatic cholangiocarcinoma.
Moirangthem A, Wang X, Yan IK, Patel T. | 09/8/2018 |
| SLC22A2 deletion is associated with motor speech disorders, and language delays. | Two unrelated children with overlapping 6q25.3 deletions, motor speech disorders, and language delays.
Peter B, Lancaster H, Vose C, Fares A, Schrauwen I, Huentelman M. | 02/10/2018 |
| inhibitory potency for morphine uptake was affected by the OCT1*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism | Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.
Meyer MJ, Seitz T, Brockmöller J, Tzvetkov MV., Free PMC Article | 01/6/2018 |
| Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity. | Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin.
Sauzay C, White-Koning M, Hennebelle I, Deluche T, Delmas C, Imbs DC, Chatelut E, Thomas F. | 12/23/2017 |