| Effects of amino acid modifications on the permeability of the pentameric sarcolipin channel. | Effects of amino acid modifications on the permeability of the pentameric sarcolipin channel.
Cao Y, Yang R, Sun J, Zhang W, Lee I, Wang W, Meng X. | 10/9/2021 |
| Sarcolipin protein is more abundantly expressed in leg than arm skeletal muscles in humans. Sarcolipin protein expression is not altered by short-term low-intensity exercise but is reduced by repeated sprint exercise. Expression in human skeletal muscle is not associated with adiposity nor resting energy expenditure in overweight men. | Sarcolipin expression in human skeletal muscle: Influence of energy balance and exercise.
Morales-Alamo D, Martinez-Canton M, Gelabert-Rebato M, Martin-Rincon M, de Pablos-Velasco P, Holmberg HC, Calbet JAL. | 03/14/2020 |
| Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin. | Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin.
Gorski PA, Ceholski DK, Young HS. | 08/18/2018 |
| Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations has been reported. | Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations.
Cao Y, Wu X, Yang R, Wang X, Sun H, Lee I. | 08/5/2017 |
| These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity. | Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1).
Desmond PF, Labuza A, Muriel J, Markwardt ML, Mancini AE, Rizzo MA, Bloch RJ., Free PMC Article | 07/8/2017 |
| analysis of transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel | Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel.
Cao Y, Wu X, Wang X, Sun H, Lee I. | 05/13/2017 |
| Phospholamban and sarcolipin are membrane proteins that differentially regulate SERCA function. (Review) | Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
Shaikh SA, Sahoo SK, Periasamy M., Free PMC Article | 11/12/2016 |
| Molecular dynamics simulations help to clarify and to understand better the SLN pentamer channel that had a hydrophobic gate and could switch Na(+) and Cl(-) ion permeability by hydrated and vacuum states. | Molecular dynamics of water and monovalent-ions transportation mechanisms of pentameric sarcolipin.
Cao Y, Wu X, Lee I, Wang X. | 10/22/2016 |
| Although SLN and PLB binding to SERCA have different functional outcomes on the coupling efficiency of SERCA, both proteins decrease the apparent Ca(2+) affinity of the pump, suggesting that SLN and PLB inhibit SERCA by using a similar mechanism. | Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
Espinoza-Fonseca LM, Autry JM, Thomas DD., Free PMC Article | 08/29/2015 |
| SLN and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2+ in human skeletal muscle. | Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
Fajardo VA, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, Gramolini AO, Quadrilatero J, Tupling AR., Free PMC Article | 09/20/2014 |
| The C-terminal tail of SLN is a distinct, essential domain in the regulation of SERCA. | Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail.
Gorski PA, Glaves JP, Vangheluwe P, Young HS., Free PMC Article | 05/18/2013 |
| The selective downregulation of SLN and enhanced sarcoplasmic reticulum Ca(2+) uptake in human AF suggest that SLN downregulation could play an important role in abnormal intracellular Ca(2+) cycling in atrial pathology. | Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation.
Shanmugam M, Molina CE, Gao S, Severac-Bastide R, Fischmeister R, Babu GJ., Free PMC Article | 09/3/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. The variation of the sarcolipin gene (SLN) in atrial fibrillation, long QT syndrome and sudden arrhythmic death syndrome.
Nyberg MT, Stoevring B, Behr ER, Ravn LS, McKenna WJ, Christiansen M. | 03/13/2008 |
| sarcolipin is likely to be an atrial chamber-specific regulator of Ca2+ cycling in heart | Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. | 01/21/2010 |
| Gene expression of SLN was studied in children with congenital heart defects. | SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects.
Vittorini S, Storti S, Parri MS, Cerillo AG, Clerico A., Free PMC Article | 01/21/2010 |
| sarcolipin binds to phospholamban and inhibits polymerization | Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).
Asahi M, Kurzydlowski K, Tada M, MacLennan DH. | 01/21/2010 |
| role in regulating sarco(endo)plasmic reticulum Ca2+-ATPase by binding to transmembrane helices alone or in association with phospholamban | Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban.
Asahi M, Sugita Y, Kurzydlowski K, De Leon S, Tada M, Toyoshima C, MacLennan DH., Free PMC Article | 01/21/2010 |