| Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway. | Interaction between STK33 and autophagy promoted renal cell carcinoma metastasis by regulating mTOR/ULK1 signaling pathway.
Li X, Lin M, Liu M, Ye H, Qin S. | 10/28/2023 |
| Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella. | Novel frameshift mutation in STK33 is associated with asthenozoospermia and multiple morphological abnormalities of the flagella.
Ma H, Zhang B, Khan A, Zhao D, Ma A, Zhou J, Khan I, Khan K, Zhang H, Zhang Y, Jiang X, Dil S, Zeb A, Rahim F, Shi Q. | 04/2/2022 |
| Data show that serine/threonine kinase 33 (STK33) can bind with extracellular signal-regulated kinase 2 (ERK2) and take part in the regulation of ERKs signaling pathway. | STK33/ERK2 signal pathway contribute the tumorigenesis of colorectal cancer HCT15 cells.
Zhang S, Wu H, Wang K, Liu M., Free PMC Article | 02/22/2020 |
| STK33 has pro-tumor function and is a critical downstream mediator of KLF4 in gastric cancer. STK33 may serve as a potential prognostic marker and therapeutic target for gastric cancer. | Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.
Kong F, Sun T, Kong X, Xie D, Li Z, Xie K., Free PMC Article | 12/21/2019 |
| inhibition of STK33 in small cell lung carcinoma cells suppressed the cell proliferation and invasion while induced cell apoptosis | Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction.
Sun EL, Liu CX, Ma ZX, Mou XY, Mu XA, Ni YH, Li XL, Zhang D, Ju YR. | 05/4/2019 |
| Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment. | STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α.
Kong F, Kong X, Du Y, Chen Y, Deng X, Zhu J, Du J, Li L, Jia Z, Xie D, Li Z, Xie K. | 01/6/2018 |
| STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes. | STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Chen C, Huang L, Zhang G, Li Y, Li L, Bai X, Liu W, Wang H, Li J., Free PMC Article | 09/9/2017 |
| STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity. | STK33 promotes hepatocellular carcinoma through binding to c-Myc.
Yang T, Song B, Zhang J, Yang GS, Zhang H, Yu WF, Wu MC, Lu JH, Shen F., Free PMC Article | 04/9/2016 |
| Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC. | STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis.
Huang L, Chen C, Zhang G, Ju Y, Zhang J, Wang H, Li J., Free PMC Article | 01/30/2016 |
| STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition. | STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
Wang P, Cheng H, Wu J, Yan A, Zhang L. | 11/28/2015 |
| The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. | The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.
Rask-Andersen M, Moschonis G, Chrousos GP, Marcus C, Dedoussis GV, Fredriksson R, Schiöth HB., Free PMC Article | 09/27/2014 |
| STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells. | STK33 kinase activity is nonessential in KRAS-dependent cancer cells.
Babij C, Zhang Y, Kurzeja RJ, Munzli A, Shehabeldin A, Fernando M, Quon K, Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F, Jackson A, Zondlo J, Sun Y, Ellison AR, Plewa CA, San MT, Robinson J, McCarter J, Schwandner R, Judd T, Carnahan J, Dussault I. | 10/29/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Analyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW., Free PMC Article | 09/15/2010 |
| STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group | Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men.
Mujica AO, Brauksiepe B, Saaler-Reinhardt S, Reuss S, Schmidt ER. | 01/21/2010 |