| Innate immune control of influenza virus interspecies adaptation via IFITM3. | Innate immune control of influenza virus interspecies adaptation via IFITM3.
Denz PJ, Speaks S, Kenney AD, Eddy AC, Papa JL, Roettger J, Scace SC, Rubrum A, Hemann EA, Forero A, Webby RJ, Bowman AS, Yount JS., Free PMC Article | 11/6/2024 |
| Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease. | Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease.
Son Y, Lee CG, Kim JS, Lee HJ. | 10/28/2023 |
| Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice. | Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
Kenney AD, Zani A, Kawahara J, Eddy AC, Wang XL, Mahesh KC, Lu M, Thomas J, Kohlmeier JE, Suthar MS, Hemann EA, Li J, Peeples ME, Hall-Stoodley L, Forero A, Cai C, Ma J, Yount JS., Free PMC Article | 04/7/2023 |
| IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. | IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.
Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina MT., Free PMC Article | 12/10/2022 |
| Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.
Tan JMJ, Garner ME, Regeimbal JM, Greene CJ, Márquez JDR, Ammendolia DA, McCluggage ARR, Li T, Wu KJ, Cemma M, Ostrowski PP, Raught B, Diamond MS, Grinstein S, Yates RM, Higgins DE, Brumell JH., Free PMC Article | 09/4/2021 |
| The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease. | The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM., Free PMC Article | 01/16/2021 |
| IFITM3 deficiency in a new knockout (KO) mouse model increases weight loss and mortality following influenza virus infections. Infected IFITM3 KO mice developed aberrant cardiac electrical activity, including decreased heart rate and irregular, arrhythmic RR (interbeat) intervals. Findings reveal an essential role for IFITM3 in limiting influenza virus replication and pathogenesis in heart tissue. | IFITM3 protects the heart during influenza virus infection.
Kenney AD, McMichael TM, Imas A, Chesarino NM, Zhang L, Dorn LE, Wu Q, Alfaour O, Amari F, Chen M, Zani A, Chemudupati M, Accornero F, Coppola V, Rajaram MVS, Yount JS., Free PMC Article | 04/11/2020 |
| Study in influenza virus infection mouse models found that Ifitm3 is rapidly up-regulated by T cells following their activation and this occurred independently of type I and II interferon and the interferon regulatory factors 3 and 7. Up-regulation of Ifitm3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection. | Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection.
Bedford JG, O'Keeffe M, Reading PC, Wakim LM., Free PMC Article | 09/28/2019 |
| this study shows that IFITM3 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation | IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.
Yánez DC, Sahni H, Ross S, Solanki A, Lau CI, Papaioannou E, Barbarulo A, Powell R, Lange UC, Adams DJ, Barenco M, Ono M, D'Acquisto F, Furmanski AL, Crompton T., Free PMC Article | 06/1/2019 |
| the role of IFITM3 in colonic epithelial homeostasis, inflammation and colitis-associated tumorigenesis using IFITM3-deficient mice, was investigated. | The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota.
Alteber Z, Sharbi-Yunger A, Pevsner-Fischer M, Blat D, Roitman L, Tzehoval E, Elinav E, Eisenbach L. | 01/19/2019 |
| The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment. | Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.
Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, Nabeshima T, Yamada K., Free PMC Article | 12/22/2018 |
| contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus replication by demethylating and activating IFITM3 which is a host restriction factor for many RNA viruses | Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B., Free PMC Article | 06/30/2018 |
| IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. | The IFITMs Inhibit Zika Virus Replication.
Savidis G, Perreira JM, Portmann JM, Meraner P, Guo Z, Green S, Brass AL. | 09/23/2017 |
| ZMPSTE24 is a downstream effector of IFITM3 and is important for interferon-induced transmembrane antiviral activity. | ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Li S, Fu B, Wang L, Dorf ME., Free PMC Article | 09/23/2017 |
| IFITM3 represents a checkpoint regulator of antiviral immunity that controls cytokine production to restrict viral pathogenesis. | The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis.
Stacey MA, Clare S, Clement M, Marsden M, Abdul-Karim J, Kane L, Harcourt K, Brandt C, Fielding CA, Smith SE, Wash RS, Brias SG, Stack G, Notley G, Cambridge EL, Isherwood C, Speak AO, Johnson Z, Ferlin W, Jones SA, Kellam P, Humphreys IR., Free PMC Article | 09/16/2017 |
| Collectively, the data define an antiviral role for Ifitm3 in restricting infection of multiple alphaviruses. | The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses.
Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS., Free PMC Article | 05/13/2017 |
| Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs. | IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.
Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP. | 04/21/2016 |
| Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence. | Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
Everitt AR, Clare S, McDonald JU, Kane L, Harcourt K, Ahras M, Lall A, Hale C, Rodgers A, Young DB, Haque A, Billker O, Tregoning JS, Dougan G, Kellam P., Free PMC Article | 12/20/2014 |
| results suggest that modification of Tyr(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3 | Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination.
Chesarino NM, McMichael TM, Hach JC, Yount JS., Free PMC Article | 06/28/2014 |
| It acts as a defence factor for virus infection, though, it also suppress endocytosis of astroglia, which results in neurodevelopmental impairment.(review) | [Neurodevelopmental impairment following neonatal immune challenge in mice].
Yamada K. | 02/1/2014 |
| Interferon-induced transmembrane protein 3 is a type II transmembrane protein. | Interferon-induced transmembrane protein 3 is a type II transmembrane protein.
Bailey CC, Kondur HR, Huang IC, Farzan M., Free PMC Article | 01/25/2014 |
| results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula | Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula.
Mikedis MM, Downs KM., Free PMC Article | 01/11/2014 |
| Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines. | Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K., Free PMC Article | 12/21/2013 |
| Jin Chai antiviral capsule exerts antiviral effects against influenza virus by raised expression of IFITM3. | [Effects of jin chai antiviral capsule on IFITM3 expression in mice].
Zhong JY, Cui XL, Shi YJ, Guo SS, Liu Y, Liu FZ, Gao YJ, Jin YH, Cao HX. | 09/28/2013 |
| lung TRM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures | Enhanced survival of lung tissue-resident memory CD8⁺ T cells during infection with influenza virus due to selective expression of IFITM3.
Wakim LM, Gupta N, Mintern JD, Villadangos JA. | 04/20/2013 |