| Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells. | Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
Garcia Delgado L, Derome A, Longpré S, Giroux-Dansereau M, Basbous G, Lavoie C, Saucier C, Denault JB., Free PMC Article | 06/30/2024 |
| Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus. | Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus.
Chandra M, Collins BM, Jackson LP., Free PMC Article | 04/16/2022 |
| Sorting nexin 1 loss results in increased oxidative stress and hypertension. | Sorting nexin 1 loss results in increased oxidative stress and hypertension.
Yang J, Asico LD, Beitelshees AL, Feranil JB, Wang X, Jones JE, Armando I, Cuevas SG, Schwartz GL, Gums JG, Chapman AB, Turner ST, Boerwinkle E, Cooper-DeHoff RM, Johnson JA, Felder RA, Weinman EJ, Zeng C, Jose PA, Villar VAM., Free PMC Article | 01/23/2021 |
| Data suggest that GLP1R signaling in pancreatic beta-cells leading to insulin secretion involves interactions of GLP1R with HIP1, SNX1, and SNX27; HIP1 appears to regulate coupling of cell surface GLP1R activation with endocytosis; SNX1 and SNX27 appear to control balance between GLP1R plasma membrane recycling and lysosomal degradation. | A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.
Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR Jr, Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A. | 05/26/2018 |
| SNX1 was down-regulated in CRC and associated with poor prognosis. Our data also showed that SNX1 inhibited the proliferation of CRC cells and increased the sensitivity to the most commonly used drugs for CRC. | Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer.
Bian Z, Feng Y, Xue Y, Hu Y, Wang Q, Zhou L, Liu Z, Zhang J, Yin Y, Gu B, Huang Z. | 02/18/2017 |
| miR-95 functions as an oncogene role in non-small cell lung cancer cells by directly targeting SNX1. | MiR-95 induces proliferation and chemo- or radioresistance through directly targeting sorting nexin1 (SNX1) in non-small cell lung cancer.
Chen X, Chen S, Hang W, Huang H, Ma H. | 04/23/2016 |
| Results show that suppression of EGFR membrane recycling by SNX1 appears to be critical for the activation of EGFR /PI3K/AKT signaling pathway in human lung cancer cells. | EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line.
Nishimura Y, Takiguchi S, Ito S, Itoh K. | 03/26/2016 |
| we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR phosphorylation and mediates EGFR/pEGFR trafficking out of early endosomes | Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines.
Nishimura Y, Takiguchi S, Yoshioka K, Nakabeppu Y, Itoh K. | 01/4/2014 |
| SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension | Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA., Free PMC Article | 03/2/2013 |
| This study found that significant evidence of association with SNX1 (VEGAS p = 0.035) in patient with Alzheimer disease. | Identification of Alzheimer disease-associated variants in genes that regulate retromer function.
Vardarajan BN, Bruesegem SY, Harbour ME, Inzelberg R, Friedland R, St George-Hyslop P, Seaman MN, Farrer LA., Free PMC Article | 12/8/2012 |
| SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition. | SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.
van Weering JR, Verkade P, Cullen PJ. | 06/16/2012 |
| Results demonstrate that miR-95 increases proliferation by directly targeting SNX1, defining miR-95 as a new oncogenic miRNA in CRC. | MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma.
Huang Z, Huang S, Wang Q, Liang L, Ni S, Wang L, Sheng W, He X, Du X. | 07/16/2011 |
| SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation. | A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.
Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. | 03/5/2011 |
| These data describe a novel function of SNX1 in the regulation of P2Y(1) receptor recycling and suggest that SNX1 plays multiple roles in endocytic trafficking of G-protein coupled receptors. | Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent.
Nisar S, Kelly E, Cullen PJ, Mundell SJ. | 07/12/2010 |
| sortilin and mannose-6-phosphate receptors recycle to the TGN in SNX1-dependent carriers, which we named endosome-to-TGN transport carriers | SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.
Mari M, Bujny MV, Zeuschner D, Geerts WJ, Griffith J, Petersen CM, Cullen PJ, Klumperman J, Geuze HJ. | 01/21/2010 |
| The loss of SNX1 may play a significant role in the development and aggressiveness of human colon cancer, at least partially through the mechanism of increased signaling from endosomes. | Sorting nexin 1 down-regulation promotes colon tumorigenesis.
Nguyen LN, Holdren MS, Nguyen AP, Furuya MH, Bianchini M, Levy E, Mordoh J, Liu A, Guncay GD, Campbell JS, Parks WT. | 01/21/2010 |
| These findings establish an essential role for endogenous SNX1 in sorting activated PAR1 to a distinct lysosomal degradative pathway that is independent of retromer, Hrs, and Tsg101. | An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.
Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J., Free PMC Article | 01/21/2010 |
| These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles. | Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
Rojas R, Kametaka S, Haft CR, Bonifacino JS., Free PMC Article | 01/21/2010 |
| controls down-regulation of protease-activated receptor-1 | Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.
Wang Y, Zhou Y, Szabo K, Haft CR, Trejo J., Free PMC Article | 01/21/2010 |
| Together, these findings demonstrate a role for SNX1 in retrieval of E-cadherin from a degradative endosomal pathway and in membrane trafficking pathways that regulate E-cadherin recycling. | EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.
Bryant DM, Kerr MC, Hammond LA, Joseph SR, Mostov KE, Teasdale RD, Stow JL. | 01/21/2010 |
| Overexpression of SNX1 is able to attenuate the effect of SNX5 on epidermal growth factor (EGF) receptor degradation. | Inhibitory regulation of EGF receptor degradation by sorting nexin 5.
Liu H, Liu ZQ, Chen CX, Magill S, Jiang Y, Liu YJ. | 01/21/2010 |
| identified sorting nexin 1 (SNX1) as a novel partner of enterothelin-1 (ENT-1); show that Ent-1 and SNX1 co-eluted in macromolecular complexes containing part of epidermal growth factor receptor(EGFR) | Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor.
Pons V, Hullin-Matsuda F, Nauze M, Barbaras R, Pérès C, Collet X, Perret B, Chap H, Gassama-Diagne A. | 01/21/2010 |
| NMR structure of the PX domain of SNX1 reveals an overall fold that is similar to high-affinity PX domains | Determinants of the endosomal localization of sorting nexin 1.
Zhong Q, Watson MJ, Lazar CS, Hounslow AM, Waltho JP, Gill GN., Free PMC Article | 01/21/2010 |
| SNX1 associates with a microdomain of the early endosome where it regulates tubular-based endosome-to-trans Golgi network retrieval of the cation-independent mannose-6-phosphate receptor. | Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT, Cullen PJ. | 01/21/2010 |
| HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains | A novel hook-related protein family and the characterization of hook-related protein 1.
Simpson F, Martin S, Evans TM, Kerr M, James DE, Parton RG, Teasdale RD, Wicking C. | 01/21/2010 |