| RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. | RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
Yuan L, Bu S, Du M, Wang Y, Ju C, Huang D, Xu W, Tan X, Liang M, Deng S, Yang L, Huang K. | 03/22/2023 |
| Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1. | Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1.
Li J, Tan J, Song Q, Yang X, Zhang X, Qin H, Huang G, Su X, Li J., Free PMC Article | 02/14/2023 |
| TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy. | TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Zeng H, Qi X, Xu X, Wu Y., Free PMC Article | 12/5/2020 |
| Study using knock-in mouse model elucidated the role of the p38alpha-TAB1 interaction during myocardial ischemia in vivo suggested that persistent p38alpha activation may be the result of the disinhibition of MAP2K3 access in the absence of TAB1 docking on p38alpha and proposed that TAB1 phosphorylation downstream of p38alpha is associated with cardiac damage during ischemia. | The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.
De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED, Verma S, Kleinjung J, Laing A, Hutchinson JP, Eaton P, Clark J, Marber MS., Free PMC Article | 12/14/2019 |
| our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development. | The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
Yang Y, Zhou C, Wang Y, Liu W, Liu C, Wang L, Liu Y, Shang Y, Li M, Zhou S, Wang Y, Zeng W, Zhou J, Huo R, Li W., Free PMC Article | 08/19/2017 |
| We confirmed that PGC-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 binding and TAK1 activation. | PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
Chen H, Liu Y, Li D, Song J, Xia M. | 10/29/2016 |
| The E3 ubiquitin ligase Itch inhibits p38alpha signaling and skin inflammation through the ubiquitylation of Tab1. | The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1.
Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, Pascual V, Wei WZ, Massoumi R, Venuprasad K. | 11/21/2015 |
| TAB1 and TAB2 are required for activated macrophages, making TAB1 and TAB2 effective targets to control inflammation by modulating macrophage survival. | Activated macrophage survival is coordinated by TAK1 binding proteins.
Mihaly SR, Morioka S, Ninomiya-Tsuji J, Takaesu G., Free PMC Article | 01/17/2015 |
| Both the MEKK1 PHD and TAB1 are critical for ES-cell differentiation | The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E., Free PMC Article | 01/3/2015 |
| The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells was attenuated by TAB1 short hairpin RNA knockdown. | Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH. | 04/19/2014 |
| TAB1 binding stabilizes active p38alpha and induces rearrangements within the activation segment by helical extension of the Thr-Gly-Tyr motif, allowing autophosphorylation in cis | Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1.
DeNicola GF, Martin ED, Chaikuad A, Bassi R, Clark J, Martino L, Verma S, Sicard P, Tata R, Atkinson RA, Knapp S, Conte MR, Marber MS., Free PMC Article | 12/7/2013 |
| We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation | TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.
Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya-Tsuji J., Free PMC Article | 01/5/2013 |
| O-GlcNAcylation of TAB1 is required for full TAK1 activation upon stimulation with IL-1/osmotic stress. | O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.
Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM., Free PMC Article | 07/21/2012 |
| Epithelial TAK1 activity is regulated through two unique, TAB1-dependent basal & TAB2-mediated stimuli-dependent mechanisms. | Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.
Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya-Tsuji J., Free PMC Article | 05/12/2012 |
| XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. | A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells.
Rochira JA, Matluk NN, Adams TL, Karaczyn AA, Oxburgh L, Hess ST, Verdi JM., Free PMC Article | 11/26/2011 |
| Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. | Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process.
Scholz R, Sidler CL, Thali RF, Winssinger N, Cheung PC, Neumann D., Free PMC Article | 09/6/2010 |
| We propose that TAB1 promotes nitric oxide-induced p38 autophosphorylation. In addition, nitric oxide-induced p38 activation seems to promote JNK inhibition and ERK activation, but this effect appears to not require TAB1. | Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells.
Makeeva N, Roomans GM, Welsh N., Free PMC Article | 01/21/2010 |
| TGF-beta1 activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells | Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells.
Kim SI, Kwak JH, Na HJ, Kim JK, Ding Y, Choi ME., Free PMC Article | 01/21/2010 |
| p38 was inactivated upon infection in a Leishmania surface protease Leishmania surface protease GP63 protein degradation-dependent manner, which likely involves cleavage of the upstream adaptor TAB1. | The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.
Hallé M, Gomez MA, Stuible M, Shimizu H, McMaster WR, Olivier M, Tremblay ML., Free PMC Article | 01/21/2010 |
| Cell shrinkage under the osmotic stress condition increases the concentration of TAB1-TAK1 and may oligomerize and activate TAK1 in a TAB1-dependent manner. | TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.
Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J., Free PMC Article | 01/21/2010 |
| a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta | Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.
Neil JR, Schiemann WP., Free PMC Article | 01/21/2010 |
| TAB1alpha, but not TAB1beta, plays an important role in the activation of p38 in insulin-producing cells and therefore also in cytokine-induced beta-cell death. | Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells.
Makeeva N, Roomans GM, Myers JW, Welsh N. | 01/21/2010 |
| another MAP3K (MAPK kinase kinase) may mediate the IL-1/TNFalpha-induced activation of these signalling pathways in TAB1(-/-) and MEKK3(-/-) MEFs | Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P. | 01/21/2010 |
| TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling | Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.
Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G. | 01/21/2010 |