| Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice. | Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
Wang X, Lu M, Gu H, Xiao T, Hu G, Luo M, Guo X, Xia Y. | 02/11/2023 |
| We report that an Smac-mimetic selectively induces TNF-alpha-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation. | Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts.
Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X., Free PMC Article | 02/1/2014 |
| Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer. | An apoptosis-independent role of SMAC in tumor suppression.
Qiu W, Liu H, Sebastini A, Sun Q, Wang H, Zhang L, Yu J., Free PMC Article | 11/2/2013 |
| Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. | Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.
Kim JB, Kim SY, Kim BM, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY., Free PMC Article | 06/29/2013 |
| Loss of Smac/DIABLO alters both caspase-dependent and caspase-independent intrinsic programmed cell death. | Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.
Hui KK, Kanungo AK, Elia AJ, Henderson JT., Free PMC Article | 02/4/2012 |
| Membrane-associated XIAP induces mitochondrial outer membrane permeabilization leading to cytochrome c and Smac release, which is dependent on Bax and Bak. | Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.
Owens TW, Foster FM, Valentijn A, Gilmore AP, Streuli CH., Free PMC Article | 02/1/2010 |
| Smac/DIABLO and Hsp-70 proteins were upregulated 2-fold and 1.5-3-fold, respectively, after birth. | Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation.
Stoka V, Turk V, Bredesen DE., Free PMC Article | 01/21/2010 |
| In response to autocrine TNFalpha signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis | Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.
Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X., Free PMC Article | 01/21/2010 |
| Bax and Bak differentially regulate the release of cytochrome c and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax and Bak genes, or resistant to TRAIL. | Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK. | 01/21/2010 |
| Regulation of Smac/Diablo mRNA and protein expression is a mechanism by which lethal stimuli amplify their lethal potential in renal cells. | Expression of Smac/Diablo in tubular epithelial cells and during acute renal failure.
Justo P, Sanz A, Lorz C, Gómez-Garre D, Mezzano S, Egido J, Ortiz A. | 01/21/2010 |
| mitochondrial activation by Bid is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release | Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis.
Li S, Zhao Y, He X, Kim TH, Kuharsky DK, Rabinowich H, Chen J, Du C, Yin XM. | 01/21/2010 |
| Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV. | Tissue distribution of Diablo/Smac revealed by monoclonal antibodies.
Tikoo A, O'Reilly L, Day CL, Verhagen AM, Pakusch M, Vaux DL. | 01/21/2010 |
| Smac/DIABLO is involved in the fragmentation and apoptosis of preimplantation embryos. | Expression of Smac/DIABLO in mouse preimplantation embryos and its correlation to apoptosis and fragmentation.
Honda Y, Tanikawa H, Fukuda J, Kawamura K, Sato N, Sato T, Shimizu Y, Kodama H, Tanaka T. | 01/21/2010 |
| These results suggest that interaction among XIAP, Smac/DIABLO, and caspase-9 plays an important role in the regulation of apoptotic neuronal cell death after transient focal cerebral ischemia. | Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.
Saito A, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH. | 01/21/2010 |
| Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol. | Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion.
Shibata M, Hattori H, Sasaki T, Gotoh J, Hamada J, Fukuuchi Y. | 01/21/2010 |
| release of Smac/DIABLO from mitochondria to cytoplasm and the subsequent activation of caspase-9 and caspase-3 play important roles in H(2)O(2)-induced apoptosis in C2C12 myogenic cells | Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells.
Jiang B, Xiao W, Shi Y, Liu M, Xiao X. | 01/21/2010 |
| data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function. | Generation and characterization of Smac/DIABLO-deficient mice.
Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW., Free PMC Article | 01/21/2010 |