LRRK2 G2019S enhances immune response pathways and aggravates asthma in mouse models.
Yang K, Zhou Y, Cui J, Tang W, Chen Y, Chen X.

Loss of mitochondrial Ca(2+) response and CaMKII/ERK activation by LRRK2(R1441G) mutation correlate with impaired depolarization-induced mitophagy.
Chang EE, Liu H, Choi ZY, Malki Y, Zhang SX, Pang SY, Kung MH, Ramsden DB, Ho SL, Ho PW., Free PMC Article

Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice.
Maekawa T, Motokawa R, Kawashima R, Tamaki S, Hara Y, Kawakami F, Ichikawa T.

TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
Zhang T, Linghu KG, Tan J, Wang M, Chen D, Shen Y, Wu J, Shi M, Zhou Y, Tang L, Liu L, Qin ZH, Guo B.,

Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.
Gupta S, Tielemans A, Guevara CA, Huntley GW, Benson DL.,

Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice.
Li D, Yu SF, Lin L, Guo JR, Huang SM, Wu XL, You HL, Cheng XJ, Zhang QY, Zeng YQ, Pan XD., Free PMC Article

The LRRK2-G2019S mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles.
An J, Yang H, Park SM, Chwae YJ, Joe EH.

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.
Wetzel A, Lei SH, Liu T, Hughes MP, Peng Y, McKay T, Waddington SN, Grannò S, Rahim AA, Harvey K., Free PMC Article

LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Zheng Z, Zhang S, Liu X, Wang X, Xue C, Wu X, Zhang X, Xu X, Liu Z, Yao L, Lu G.

LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation.
Wang Y, Gao JZ, Sakaguchi T, Maretzky T, Gurung P, Narayanan NS, Short S, Xiong Y, Kang Z., Free PMC Article

Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2.
Dues DJ, Ma Y, Nguyen APT, Offerman AV, Beddows I, Moore DJ., Free PMC Article

Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking.
da Silva D, Matsui A, Murray EM, Mamais A, Authement ME, Shin JH, Shaw M, Ron D, Cookson MR, Alvarez VA., Free PMC Article

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression.
Lubben N, Brynildsen JK, Webb CM, Li HL, Leyns CEG, Changolkar L, Zhang B, Meymand ES, O'Reilly M, Madaj Z, DeWeerd D, Fell MJ, Lee VMY, Bassett DS, Henderson MX., Free PMC Article

Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes.
Unapanta A, Shavarebi F, Porath J, Shen Y, Balen C, Nguyen A, Tseng J, Leong WS, Liu M, Lis P, Di Pietro SM, Hiniker A., Free PMC Article

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR., Free PMC Article

Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis.
Otsuka Y, Hara A, Minaga K, Sekai I, Kurimoto M, Masuta Y, Takada R, Yoshikawa T, Kamata K, Kudo M, Watanabe T., Free PMC Article

LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes.
Kawakami F, Imai M, Isaka Y, Cookson MR, Maruyama H, Kubo M, Farrer MJ, Kanzaki M, Kawashima R, Maekawa T, Tamaki S, Kurosaki Y, Kojima F, Ohba K, Ichikawa T., Free PMC Article

LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF-β1 in Parkinson's Disease.
Yao L, Lu F, Koc S, Zheng Z, Wang B, Zhang S, Skutella T, Lu G., Free PMC Article

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.
Zhang S, Qian S, Liu H, Xu D, Xia W, Duan H, Wang C, Yu S, Chen Y, Ji P, Wang S, Cui X, Wang Y, Shen H., Free PMC Article

LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation.
Mutti V, Carini G, Filippini A, Castrezzati S, Giugno L, Gennarelli M, Russo I., Free PMC Article

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis.
Cabezudo D, Tsafaras G, Van Acker E, Van den Haute C, Baekelandt V., Free PMC Article

Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.
Feng L, Lo H, Hong Z, Zheng J, Yan Y, Ye Z, Chen X, Pan X.

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages.
Oun A, Hoeksema E, Soliman A, Brouwer F, García-Reyes F, Pots H, Trombetta-Lima M, Kortholt A, Dolga AM., Free PMC Article

Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
Yu Y, Ren Y, Li Z, Li Y, Li Y, Zhang Y, Gui R, Cui Y, Qian L, Xiong Y., Free PMC Article

Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.
Sitzia G, Skiteva O, Chergui K., Free PMC Article