| Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. | Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.
Deehan MA, Kothuis JM, Sapp E, Chase K, Ke Y, Seeley C, Iuliano M, Kim E, Kennington L, Miller R, Boudi A, Shing K, Li X, Pfister E, Anaclet C, Brodsky M, Kegel-Gleason K, Aronin N, DiFiglia M., Free PMC Article | 04/10/2024 |
| NAC1 confines virus-specific memory formation of CD4[+] T cells through the ROCK1-mediated pathway. | NAC1 confines virus-specific memory formation of CD4(+) T cells through the ROCK1-mediated pathway.
Wang L, Peng HY, Kishore Das J, Kumar A, Ren Y, Ballard DJ, Xiong X, Yang W, Ren X, de Figueiredo P, Yang JM, Song J., Free PMC Article | 07/24/2023 |
| Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion. | Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.
Ren Y, Kumar A, Das JK, Peng HY, Wang L, Balllard D, Xiong X, Ren X, Zhang Y, Yang JM, Song J., Free PMC Article | 10/15/2022 |
| these results reveal the genome wide role for Nac1 in the contribution to the pluripotency circuitry and the regulation of the establishing pluripotent state. | Nac1 facilitates pluripotency gene activation for establishing somatic cell reprogramming.
Choi H, Park HJ, Kim H, Kim J, Lee YK, Kim J. | 06/13/2020 |
| NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression. | NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.
Faiola F, Yin N, Fidalgo M, Huang X, Saunders A, Ding J, Guallar D, Dang B, Wang J., Free PMC Article | 05/19/2018 |
| Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc promoter and regulates c-Myc transcription. | Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc.
Ruan Y, He J, Wu W, He P, Tian Y, Xiao L, Liu G, Wang J, Cheng Y, Zhang S, Yang Y, Xiong J, Zhao K, Wan Y, Huang H, Zhang J, Jian R., Free PMC Article | 04/28/2018 |
| a sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates. | Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation.
Malleshaiah M, Padi M, Rué P, Quackenbush J, Martinez-Arias A, Gunawardena J., Free PMC Article | 11/5/2016 |
| The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian cancer. | Nac1 interacts with the POZ-domain transcription factor, Miz1.
Stead MA, Wright SC., Free PMC Article | 02/14/2015 |
| NAC1 participates in the motility and differentiation of developing chondrocytes and cartilaginous tissues, and its expression is necessary to maintain normal axial patterning of murine skeleton. | Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis.
Yap KL, Sysa-Shah P, Bolon B, Wu RC, Gao M, Herlinger AL, Wang F, Faiola F, Huso D, Gabrielson K, Wang TL, Wang J, Shih IeM., Free PMC Article | 05/3/2014 |
| Nanog interacts with Nac1 through WNAAP to regulate the cell cycle of stem cells via the ERas/phosphatidylinositol 3-kinase/Akt pathway, but not pluripotency | The C-terminal pentapeptide of Nanog tryptophan repeat domain interacts with Nac1 and regulates stem cell proliferation but not pluripotency.
Ma T, Wang Z, Guo Y, Pei D., Free PMC Article | 01/21/2010 |
| these data indicate involvement of NAC1 in the acute behavioral and neurochemical responses to psychomotor stimulants | Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response.
Mackler S, Pacchioni A, Degnan R, Homan Y, Conti AC, Kalivas P, Blendy JA., Free PMC Article | 01/21/2010 |
| The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat. | The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1.
Mackler SA, Homan YX, Korutla L, Conti AC, Blendy JA. | 01/21/2010 |