| Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS. | Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS.
Li W, Liu Q, Qian Y, Wang C, Kong C, Sun L, Sun L, Liu H, Zhang Y, Jiang D, Jiang C, Wang S, Xia P. | 10/31/2024 |
| SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL. | SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
Guan H, Xiao L, Hao K, Zhang Q, Wu D, Geng Z, Duan B, Dai H, Xu R, Feng X., Free PMC Article | 06/25/2024 |
| Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL. | Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL.
Ding L, Huwyler F, Long F, Yang W, Binz J, Wernlé K, Pfister M, Klug M, Balaz M, Ukropcova B, Ukropec J, Wu C, Wang T, Gao M, Clavien PA, Dutkowski P, Tibbitt MW, Wolfrum C., Free PMC Article | 04/24/2024 |
| Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity. | Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity.
Fernandes MF, Aristizabal-Henao JJ, Marvyn PM, M'Hiri I, Wiens MA, Hoang M, Sebastian M, Nachbar R, St-Pierre P, Diaguarachchige De Silva K, Wood GA, Joseph JW, Doucette CA, Marette A, Stark KD, Duncan RE., Free PMC Article | 03/11/2024 |
| Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58. | Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
Kulminskaya N, Rodriguez Gamez CF, Hofer P, Cerk IK, Dubey N, Viertlmayr R, Sagmeister T, Pavkov-Keller T, Zechner R, Oberer M., Free PMC Article | 01/30/2024 |
| PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle. | PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G., Free PMC Article | 10/5/2023 |
| Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration. | Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
Bernardo-Colón A, Dong L, Abu-Asab M, Brush RS, Agbaga MP, Becerra SP., Free PMC Article | 05/28/2023 |
| Adipose Triglyceride Lipase Deficiency Aggravates Angiotensin II-Induced Atrial Fibrillation by Reducing Peroxisome Proliferator-Activated Receptor alpha Activation in Mice. | Adipose Triglyceride Lipase Deficiency Aggravates Angiotensin II-Induced Atrial Fibrillation by Reducing Peroxisome Proliferator-Activated Receptor α Activation in Mice.
Han X, Zhang YL, Zhao YX, Guo SB, Yin WP, Li HH. | 03/2/2023 |
| N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage. | N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage.
Xu J, Liu Z, Zhang J, Chen S, Wang W, Zhao X, Zhen M, Huang X., Free PMC Article | 01/28/2023 |
| Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency. | Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency.
Oluwadare J, Cabodevilla AG, Son NH, Hu Y, Mullick AE, Verano M, Alemán JO, Ramasamy R, Goldberg IJ., Free PMC Article | 12/3/2022 |
| ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. | ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB., Free PMC Article | 07/9/2022 |
| Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis. | Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis.
Korbelius M, Vujić N, Kuentzel KB, Obrowsky S, Rainer S, Haemmerle G, Rülicke T, Kratky D., Free PMC Article | 05/21/2022 |
| Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo. | Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Goeritzer M, Schlager S, Kuentzel KB, Vujić N, Korbelius M, Rainer S, Kolb D, Mussbacher M, Salzmann M, Schrottmaier WC, Assinger A, Schlagenhauf A, Madreiter-Sokolowski CT, Blass S, Eichmann TO, Graier WF, Kratky D., Free PMC Article | 04/16/2022 |
| A simple, rapid, and sensitive fluorescence-based method to assess triacylglycerol hydrolase activity. | A simple, rapid, and sensitive fluorescence-based method to assess triacylglycerol hydrolase activity.
Rajan S, de Guzman HC, Palaia T, Goldberg IJ, Hussain MM., Free PMC Article | 03/26/2022 |
| Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice. | Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice.
Kaur S, Auger C, Barayan D, Shah P, Matveev A, Knuth CM, Harris TE, Jeschke MG., Free PMC Article | 02/12/2022 |
| Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. | 01/15/2022 |
| Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice. | Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice.
Noguchi H, Yamada S, Hirano KI, Yamaguchi S, Suzuki A, Guo X, Zaima N, Li M, Kobayashi K, Ikeda Y, Nakayama T, Sasaguri Y. | 11/22/2021 |
| Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. | Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
Schwerbel K, Kamitz A, Krahmer N, Hallahan N, Jähnert M, Gottmann P, Lebek S, Schallschmidt T, Arends D, Schumacher F, Kleuser B, Haltenhof T, Heyd F, Gancheva S, Broman KW, Roden M, Joost HG, Chadt A, Al-Hasani H, Vogel H, Jonas W, Schürmann A., Free PMC Article | 11/22/2021 |
| Morphine increases myocardial triacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation. | Morphine increases myocardial triacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation.
Li L, Wang J, Li D, Zhang H. | 09/18/2021 |
| ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes. | ATGL activity regulates GLUT1-mediated glucose uptake and lactate production via TXNIP stability in adipocytes.
Beg M, Zhang W, McCourt AC, Enerbäck S., Free PMC Article | 08/28/2021 |
| Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy. | Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy.
Zhou H, Lei X, Yan Y, Lydic T, Li J, Weintraub NL, Su H, Chen W., Free PMC Article | 09/26/2020 |
| In summary, our data reveal new cellular and physiological mechanisms underlying the beneficial effects of 5-PAHSA and its relation to insulin action in adipocytes and independently confirm a PAHSA metabolite reservoir linked to ATGL-mediated lipolysis. | Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice.
Paluchova V, Oseeva M, Brezinova M, Cajka T, Bardova K, Adamcova K, Zacek P, Brejchova K, Balas L, Chodounska H, Kudova E, Schreiber R, Zechner R, Durand T, Rossmeisl M, Abumrad NA, Kopecky J, Kuda O., Free PMC Article | 08/13/2020 |
| The role of ATGL and its deficiency in lipid and glucose homeostasis in humans and transgenic mice has been discussed. (Review) | The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice.
Trites MJ, Clugston RD., Free PMC Article | 05/9/2020 |
| ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo. | Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.
Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, Kolb D, Hoeks J, Kershaw EE, Sedej S, Schrauwen P, Haemmerle G, Zechner R., Free PMC Article | 07/14/2018 |
| Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure. | Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
Salatzki J, Foryst-Ludwig A, Bentele K, Blumrich A, Smeir E, Ban Z, Brix S, Grune J, Beyhoff N, Klopfleisch R, Dunst S, Surma MA, Klose C, Rothe M, Heinzel FR, Krannich A, Kershaw EE, Beule D, Schulze PC, Marx N, Kintscher U., Free PMC Article | 06/23/2018 |