| Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice. | Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z., Free PMC Article | 02/16/2023 |
| Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum. | Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum.
Gu Y, Yang Y, Cao X, Zhao Y, Gao X, Sun C, Zhang F, Yuan Y, Xu Y, Zhang J, Xiao L, Ye J. | 08/22/2020 |
| These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression. | Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARα Activation.
Lee YK, Sohn JH, Han JS, Park YJ, Jeon YG, Ji Y, Dalen KT, Sztalryd C, Kimmel AR, Kim JB., Free PMC Article | 05/26/2018 |
| our studies demonstrate that the lipid droplets (LDs) scaffold protein, PLIN3, is essential for HCV core-induced hepatic steatosis and provide new insights into the pathogenesis of HCV. | The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM., Free PMC Article | 08/26/2017 |
| Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages. | Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages.
Varela LM, López S, Ortega-Gómez A, Bermúdez B, Buers I, Robenek H, Muriana FJ, Abia R. | 02/13/2016 |
| Collectively these data suggest that whereas perilipin 1 potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis | Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.
Patel S, Yang W, Kozusko K, Saudek V, Savage DB., Free PMC Article | 08/23/2014 |
| Data indicate that PLIN2 and PLIN3 may participate in acute lipid droplet formation in mammalian testes. | Transient scrotal hyperthermia induces lipid droplet accumulation and reveals a different ADFP expression pattern between the testes and liver in mice.
Liu M, Qi L, Zeng Y, Yang Y, Bi Y, Shi X, Zhu H, Zhou Z, Sha J., Free PMC Article | 04/6/2013 |
| These findings show that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders. | Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.
Carr RM, Patel RT, Rao V, Dhir R, Graham MJ, Crooke RM, Ahima RS., Free PMC Article | 06/23/2012 |
| Overexpression of tail interacting protein of 47 kDa (TIP47), but not its truncated form (t-TIP47) protected NIH3T3 cells from hydrogen-peroxide-induced cell death, prevented the hydrogen-peroxide-induced mitochondrial depolarization. | TIP47 protects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death.
Hocsak E, Racz B, Szabo A, Mester L, Rapolti E, Pozsgai E, Javor S, Bellyei S, Gallyas F Jr, Sumegi B, Szigeti A. | 07/12/2010 |
| These results suggest distinct roles for TIP47 and adipophilin in dietary fat absorption. | Differential association of adipophilin and TIP47 proteins with cytoplasmic lipid droplets in mouse enterocytes during dietary fat absorption.
Lee B, Zhu J, Wolins NE, Cheng JX, Buhman KK. | 01/21/2010 |
| Membrane-permeable diacylglycerols drive Perilipin 3 onto the endoplasmic reticulum. | Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization.
Skinner JR, Shew TM, Schwartz DM, Tzekov A, Lepus CM, Abumrad NA, Wolins NE., Free PMC Article | 01/21/2010 |
| Data establish an important role for Tip47 proteins as surfactant at the LD surface, packaging lipids in smaller units and restricting access of lipases and thus preventing insulin resistance. | Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance.
Bell M, Wang H, Chen H, McLenithan JC, Gong DW, Yang RZ, Yu D, Fried SK, Quon MJ, Londos C, Sztalryd C., Free PMC Article | 01/21/2010 |
| Adipophilin and TIP47 are expressed in LDs of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. | Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.
Straub BK, Stoeffel P, Heid H, Zimbelmann R, Schirmacher P. | 01/21/2010 |
| the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess | S3-12, Adipophilin, and TIP47 package lipid in adipocytes.
Wolins NE, Quaynor BK, Skinner JR, Schoenfish MJ, Tzekov A, Bickel PE. | 01/21/2010 |