| Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver. | Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver.
Saverino A, Qu X, Mendoza RG, Raha S, Manna D, Ermi AG, Subler MA, Windle JJ, Liu J, Sarkar D., Free PMC Article | 07/23/2024 |
| Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy. | Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.
Leem E, Kim S, Sharma C, Nam Y, Kim TY, Shin M, Lee SG, Kim J, Kim SR., Free PMC Article | 04/2/2024 |
| Metadherin orchestrates PKA and PKM2 to activate beta-catenin signaling in podocytes during proteinuric chronic kidney disease. | Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.
Chen X, Xiao J, Tao D, Liang Y, Chen S, Shen L, Li S, Zheng Z, Zeng Y, Luo C, Peng F, Long H. | 03/12/2024 |
| Expression patterns of AEG-1 in the normal brain. | Expression patterns of AEG-1 in the normal brain.
Kim H, Choi M, Han S, Park SY, Jeong M, Kim SR, Hwang EM, Lee SG. | 09/1/2023 |
| Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. | Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
Komaniecki G, Camarena MDC, Gelsleichter E, Mendoza R, Subler M, Windle JJ, Dozmorov MG, Lai Z, Sarkar D, Lin H., Free PMC Article | 01/28/2023 |
| Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. | Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin.
Rajesh Y, Reghupaty SC, Mendoza RG, Manna D, Banerjee I, Subler MA, Weldon K, Lai Z, Giashuddin S, Fisher PB, Sanyal AJ, Martin RK, Dozmorov MG, Windle JJ, Sarkar D., Free PMC Article | 05/14/2022 |
| Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. | Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Shen M, Wei Y, Kim H, Wan L, Jiang YZ, Hang X, Raba M, Remiszewski S, Rowicki M, Wu CG, Wu S, Zhang L, Lu X, Yuan M, Smith HA, Zheng A, Bertino J, Jin JF, Xing Y, Shao ZM, Kang Y., Free PMC Article | 04/30/2022 |
| The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review. | The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review.
Khan M, Sarkar D., Free PMC Article | 07/24/2021 |
| A novel metadherinDelta7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFkB-SIRT3 axis. | A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis.
Neeli PK, Gollavilli PN, Mallappa S, Hari SG, Kotamraju S. | 11/28/2020 |
| Investigated the therapeutic efficacy of micheliolide (MCL) on renal fibrosis in vivo and in vitro and further investigate the underlying mechanism of metadherin (Mtdh) as a target of MCL in this condition. | Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway.
Peng F, Li H, Li S, Wang Y, Liu W, Gong W, Yin B, Chen S, Zhang Y, Luo C, Zhou W, Chen Y, Li P, Huang Q, Xu Z, Long H., Free PMC Article | 06/27/2020 |
| AEG-1 has a role in regulating macrophage activation; AEG-1 is required in both tumor cells and tumor microenvironment to stimulate hepatocarcinogenesis | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Robertson CL, Mendoza RG, Jariwala N, Dozmorov M, Mukhopadhyay ND, Subler MA, Windle JJ, Lai Z, Fisher PB, Ghosh S, Sarkar D., Free PMC Article | 10/12/2019 |
| Data show MTDH mRNA expression upregulated in cervical cancer tissues and inversely correlated with miR-433 expression. Its knockdown showed similar tumor-suppressive roles as miR-433 overexpression in regards to cervical cancer cell proliferation, invasion and apoptosis. MTDH overexpression markedly reversed the effects of miR-433 overexpression in regards to proliferation, invasion and of cervical cancer cells. | MicroRNA-433 inhibits cervical cancer progression by directly targeting metadherin to regulate the AKT and β-catenin signalling pathways.
Liang C, Ding J, Yang Y, Deng L, Li X. | 07/28/2018 |
| Up regulation of AEG protein plays a role in the pathogenesis of NAFLD. | A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH).
Srivastava J, Robertson CL, Ebeid K, Dozmorov M, Rajasekaran D, Mendoza R, Siddiq A, Akiel MA, Jariwala N, Shen XN, Windle JJ, Subler MA, Mukhopadhyay ND, Giashuddin S, Ghosh S, Lai Z, Chen Y, Fisher PB, Salem AK, Sanyal AJ, Sarkar D., Free PMC Article | 04/10/2018 |
| miR-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin | Down-regulated miR-26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma.
Yang C, Zheng S, Liu T, Liu Q, Dai F, Zhou J, Chen Y, Sheyhidin I, Lu X. | 10/7/2017 |
| Mtdh is a potent modulator of podocyte apoptosis. | Metadherin facilitates podocyte apoptosis in diabetic nephropathy.
Liu WT, Peng FF, Li HY, Chen XW, Gong WQ, Chen WJ, Chen YH, Li PL, Li ST, Xu ZZ, Long HB., Free PMC Article | 09/2/2017 |
| AEG-1 thus might play a role in NTIS associated with HCC and other cancers. | Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).
Srivastava J, Robertson CL, Gredler R, Siddiq A, Rajasekaran D, Akiel MA, Emdad L, Mas V, Mukhopadhyay ND, Fisher PB, Sarkar D., Free PMC Article | 02/27/2016 |
| When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all. | Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis.
Robertson CL, Srivastava J, Siddiq A, Gredler R, Emdad L, Rajasekaran D, Akiel M, Shen XN, Corwin F, Sundaresan G, Zweit J, Croniger C, Gao X, Ghosh S, Hylemon PB, Subler MA, Windle JJ, Fisher PB, Sarkar D., Free PMC Article | 10/17/2015 |
| MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis | Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
Meng X, Yang S, Zhang Y, Wang X, Goodfellow RX, Jia Y, Thiel KW, Reyes HD, Yang B, Leslie KK., Free PMC Article | 08/8/2015 |
| Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer. | Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.
Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Köhler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Laßmann S, Wäsch R, Zeiser R. | 05/16/2015 |
| RNA-sequencing analysis identified a unique gene signature in livers of Alb/AEG-1/c-Myc mice that was not observed when either AEG-1 or c-Myc was overexpressed | Astrocyte elevated gene-1 and c-Myc cooperate to promote hepatocarcinogenesis in mice.
Srivastava J, Siddiq A, Gredler R, Shen XN, Rajasekaran D, Robertson CL, Subler MA, Windle JJ, Dumur CI, Mukhopadhyay ND, Garcia D, Lai Z, Chen Y, Balaji U, Fisher PB, Sarkar D., Free PMC Article | 04/25/2015 |
| Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis. | Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y., Free PMC Article | 01/24/2015 |
| IL-1beta- or TNF-alpha-induced AEG-1 interaction with NF-kappaB p65 subunit. | Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-κB signaling and excitatory amino acid transporter-2 repression.
Vartak-Sharma N, Gelman BB, Joshi C, Borgamann K, Ghorpade A., Free PMC Article | 10/4/2014 |
| MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1. | MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, Xing Y, Kang Y., Free PMC Article | 09/13/2014 |
| oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer | The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer.
Zhang N, Wang X, Huo Q, Li X, Wang H, Schneider P, Hu G, Yang Q., Free PMC Article | 06/1/2013 |
| The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury. | Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration.
Vartak-Sharma N, Ghorpade A., Free PMC Article | 04/20/2013 |