| Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway. | Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway.
Dong B, Xue R, Li J, Ling S, Xing W, Liu Z, Yuan X, Pan J, Du R, Shen X, Zhang J, Zhang Y, Li Y, Zhong G., Free PMC Article | 06/27/2024 |
| CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy. | CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy.
Xiao J, Huang X, Wang H, Peng Y, Liu H, Huang H, Ma L, Wang C, Wang X, Cao Z. | 10/24/2023 |
| [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease]. | [Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease].
Li L, Xie P, Bi CS, Wang TY, Wang N, Lin WW, Zhang C, An W, Zhan YT. | 02/10/2023 |
| The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article). | The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Yang Y, Xiao H, Lin Z, Chen R, Li S, Li C, Sun X, Hei Z, Gong W, Huang H. | 12/10/2022 |
| Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization. | Ckip-1 Mediates P. gingivalis-Suppressed Cementoblast Mineralization.
Huang X, Ma L, Wang X, Wang H, Peng Y, Gao X, Huang H, Chen Y, Zhang Y, Cao Z. | 04/30/2022 |
| CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes. | CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H. | 11/22/2021 |
| CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells. | CKIP-1 contributes to osteogenic differentiation of mouse bone marrow mesenchymal stem cells.
Niu Q, Shen S, He J, Wang L. | 10/30/2021 |
| 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein. | 3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.
Zhao Y, Ling S, Li J, Zhong G, Du R, Li Y, Wang Y, Liu C, Jin X, Liu W, Liu T, Li Y, Zhao D, Sun W, Liu Z, Liu Z, Pan J, Yuan X, Gao X, Xing W, Chang YZ, Li Y. | 10/23/2021 |
| Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells. | Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells.
Tian XG, Gong FF, Li X, Meng FH, Zhou Z, Zhang HZ., Free PMC Article | 07/10/2021 |
| CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway. | CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway.
Li L, Xie P, Lin W, Liu J, Chen J, Guo Z, Bin C, An W, Zhang C, Zhan Y. | 05/1/2021 |
| Superior CKIP-1 sensitivity of orofacial bone-derived mesenchymal stem cells in proliferation and osteogenic differentiation compared to long bone-derived mesenchymal stem cells. | Superior CKIP-1 sensitivity of orofacial bone-derived mesenchymal stem cells in proliferation and osteogenic differentiation compared to long bone-derived mesenchymal stem cells.
Huang X, Cheng B, Song W, Wang L, Zhang Y, Hou Y, Song Y, Kong L., Free PMC Article | 04/17/2021 |
| Data reveal a novel role for CKIP-1 in regulating MSC-mediated immunomodulation, and indicate that MSCs become more immunosuppressive under high glucose conditions. | CKIP-1 regulates the immunomodulatory function of mesenchymal stem cells.
He Y, Chen JF, Yang YM, Huang XH, Dong XH, Yang HX, Cao JK, Jiang XX. | 02/22/2020 |
| CKIP-1 was a target gene of let-7a. | Let-7a promotes microglia M2 polarization by targeting CKIP-1 following ICH.
Yang Z, Jiang X, Zhang J, Huang X, Zhang X, Wang J, Shi H, Yu A. | 07/27/2019 |
| PLEKHO1 was highly expressed in osteoblasts from RA patients and CIA mice. Osteoblastic Plekho1 deletion ameliorated joint inflammation, whereas overexpressing Plekho1 only within osteoblasts exacerbated local inflammation. | Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis.
He X, Liu J, Liang C, Badshah SA, Zheng K, Dang L, Guo B, Li D, Lu C, Guo Q, Fan D, Bian Y, Feng H, Xiao L, Pan X, Xiao C, Zhang B, Zhang G, Lu A., Free PMC Article | 07/13/2019 |
| CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGgamma. | CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ.
Fan J, Liu L, Liu Q, Cui Y, Yao B, Zhang M, Gao Y, Fu Y, Dai H, Pan J, Qiu Y, Liu CH, He F, Wang Y, Zhang L., Free PMC Article | 02/16/2019 |
| The aim of this study was to investigate the effect of constrained dynamic loading (Loading) in combination with CKIP1 gene knockout (KO) on unloadinginduced bone loss in tailsuspension mice. | Effects of constrained dynamic loading, CKIP‑1 gene knockout and combination stimulations on bone loss caused by mechanical unloading.
Han B, Wei SP, Zhang XC, Li H, Li Y, Li RX, Li K, Zhang XZ. | 11/3/2018 |
| the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression | Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis.
Liu J, Lu C, Wu X, Zhang Z, Li J, Guo B, Li D, Liang C, Dang L, Pan X, Peng S, Lu A, Zhang B, Zhang G., Free PMC Article | 10/20/2018 |
| we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. | A novel role of CKIP-1 in promoting megakaryocytic differentiation.
Fan J, Wang Y, Shen Y, Liu Q, Gao R, Qiu Y, Wang C, Zhang L., Free PMC Article | 03/10/2018 |
| PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 | Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Gong W, Li J, Chen Z, Huang J, Chen Q, Cai W, Liu P, Huang H. | 12/16/2017 |
| these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. | Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Chen Y, Liu W, Wang Y, Zhang L, Wei J, Zhang X, He F, Zhang L. | 12/2/2017 |
| The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 phosphorylation and further upregulating IRS-1 phosphorylation and RI. | Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice.
Zhan Y, Xie P, Li D, Li L, Chen J, An W, Zhang L, Zhang C. | 08/26/2017 |
| the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. | Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
Liu J, Liang C, Guo B, Wu X, Li D, Zhang Z, Zheng K, Dang L, He X, Lu C, Peng S, Pan X, Zhang BT, Lu A, Zhang G., Free PMC Article | 06/24/2017 |
| Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1) and fibronectin plus activation of Nrf2/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway. | CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.
Gong W, Chen C, Xiong F, Yang Z, Wang Y, Huang J, Liu P, Huang H. | 05/13/2017 |
| the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis | CKIP-1 knockout offsets osteoporosis induced by simulated microgravity.
Zhang X, Wang Q, Wan Z, Li J, Liu L, Zhang X. | 05/6/2017 |
| CKIP-1 is a novel inhibitor of MSC-originated adipogenesis by enhancing HDAC1-associated repression of C/EBPalpha. | CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
Li D, Zhu H, Liang C, Li W, Xing G, Ma L, Ding L, Zhang Y, He F, Zhang L. | 09/5/2015 |