| ABCG5 and ABCG8 Are Involved in Vitamin K Transport. | ABCG5 and ABCG8 Are Involved in Vitamin K Transport.
Matsuo M, Ogata Y, Yamanashi Y, Takada T., Free PMC Article | 02/28/2023 |
| The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine. | The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine.
Antoine T, Le May C, Margier M, Halimi C, Nowicki M, Defoort C, Svilar L, Reboul E. | 04/9/2022 |
| Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon. | Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon.
Mishima Y, Sonoyama H, Ishihara S, Oshima N, Moriyama I, Kawashima K, Kinoshita Y. | 09/26/2020 |
| ABCG5 and ABCG8 mRNA levels were significantly increased in cholesterol group and less increased in myriocin group, relative to that in normal group. | Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone.
Kim HJ, Kim JS, Oh S, Yoo HS. | 12/23/2017 |
| The ABCG5/G8-independent pathway plays an important role in regulating biliary cholesterol secretion, and gallstone formation, which works independently of the ABCG5/G8 pathway. | Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice.
Wang HH, Li X, Patel SB, Wang DQ., Free PMC Article | 08/5/2017 |
| ABCG5/G8 mediate mass biliary cholesterol secretion but not from a reverse cholesterol transport-relevant pool. | Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT.
Dikkers A, de Boer JF, Groen AK, Tietge UJ. | 09/17/2016 |
| AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db strain. Both G5 and G8 protein levels increased as did total biliary cholesterol | GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice.
Wang Y, Su K, Sabeva NS, Ji A, van der Westhuyzen DR, Foufelle F, Gao X, Graf GA., Free PMC Article | 01/23/2016 |
| The data demonstrate that Abcg5/Abcg8 deficiency reduces the uptake and secretion of both dietary triacylglycerols and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons. | ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph.
Zhang LS, Xu M, Yang Q, Lou D, Howles PN, Tso P., Free PMC Article | 12/5/2015 |
| Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8) mapped to the STSL locus. Polymorphic variations in STSL have been linked to lipid levels and gallstone disease | Recent advances in understanding the STSL locus and ABCG5/ABCG8 biology.
Patel SB. | 12/20/2014 |
| The absence of an ABCG5/ABCG8 expression. | Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment.
Altemus JB, Patel SB, Sehayek E. | 11/22/2014 |
| biliary cholesterol mass secretion under maximal bile salt-stimulated conditions is fully dependent on ABCG5/G8 | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice.
Dikkers A, Freak de Boer J, Annema W, Groen AK, Tietge UJ. | 08/31/2013 |
| This study is the first to report such toxic effects of phytosterol accumulation in ABCG5/G8 knockout mice. | Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.
McDaniel AL, Alger HM, Sawyer JK, Kelley KL, Kock ND, Brown JM, Temel RE, Rudel LL., Free PMC Article | 08/31/2013 |
| handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency | ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.
Nguyen TM, Sawyer JK, Kelley KL, Davis MA, Kent CR, Rudel LL., Free PMC Article | 11/24/2012 |
| The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation | The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation.
Su K, Sabeva NS, Liu J, Wang Y, Bhatnagar S, van der Westhuyzen DR, Graf GA., Free PMC Article | 11/3/2012 |
| ABCG5/G8 deficiency in mice markedly raises triglyceride levels by impairing triglyceride catabolism and by increasing liver and intestinal triglyceride secretion. | ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways.
Méndez-González J, Julve J, Rotllan N, Llaverias G, Blanco-Vaca F, Escolà-Gil JC. | 03/31/2012 |
| NPC2 is a positive regulator of biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport. | NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.
Yamanashi Y, Takada T, Yoshikado T, Shoda J, Suzuki H. | 07/2/2011 |
| NBD1, although not required for ATP hydrolysis, is essential for normal function of G5G8 in sterol transport | Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport.
Wang J, Grishin N, Kinch L, Cohen JC, Hobbs HH, Xie XS., Free PMC Article | 05/7/2011 |
| Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. | Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.
Wiersma H, Gatti A, Nijstad N, Oude Elferink RP, Kuipers F, Tietge UJ. | 01/21/2010 |
| ABCG8 mice develop sitosterolemia, a genetic disorder characterized by the accumulation of phytosterols in blood and tissues | Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.
Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. | 01/21/2010 |
| LXR activation stimulated the fecal excretion of labeled cholesterol after an intravenous injection of HDL-[(3)H]cholesteryl oleate in G5/G8(+/+) mice, but failed to enhance fecal [(3)H]cholesterol in G5/G8(-/-) mice. | Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8.
Calpe-Berdiel L, Rotllan N, Fiévet C, Roig R, Blanco-Vaca F, Escolà-Gil JC. | 01/21/2010 |
| Increased biliary cholesterol excretion in Atp8b1-deficient mice is independent of Abcg5/8 activity. | Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
Groen A, Kunne C, Jongsma G, van den Oever K, Mok KS, Petruzzelli M, Vrins CL, Bull L, Paulusma CC, Oude Elferink RP. | 01/21/2010 |
| The cholesterol transporters Npc1l1, Abca1, Abcg5, and Abcg8 were found to be downregulated after 2, 4, and 8 wk on a cholesterol-free, high-fat diet. | A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.
de Vogel-van den Bosch HM, de Wit NJ, Hooiveld GJ, Vermeulen H, van der Veen JN, Houten SM, Kuipers F, Müller M, van der Meer R. | 01/21/2010 |
| Both ABCG5 (G5) and ABCG8 (G8) have short but highly conserved cytoplasmic tails | Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.
Wang J, Zhang DW, Lei Y, Xu F, Cohen JC, Hobbs HH, Xie XS., Free PMC Article | 01/21/2010 |
| Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations. | Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.
Kruit JK, Drayer AL, Bloks VW, Blom N, Olthof SG, Sauer PJ, de Haan G, Kema IP, Vellenga E, Kuipers F. | 01/21/2010 |
| Cholesterol secretion was highly bile salt dependent, whereas other cholesterol acceptors such as ApoAI, HDL or methyl-beta-cyclodextrin did not elicit Abcg5/g8 dependent cholesterol secretion | The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux.
Vrins C, Vink E, Vandenberghe KE, Frijters R, Seppen J, Groen AK. | 01/21/2010 |