| Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion. | Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion.
Ye F, Yuan Z, Tang Y, Li J, Liu X, Sun X, Chen S, Ye X, Zeng Z, Zhang XK, Zhou H. | 05/10/2024 |
| Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis. | Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis.
Serra G, Memo L, Cavicchioli P, Cutrone M, Giuffrè M, La Torre ML, Schierz IAM, Corsello G., Free PMC Article | 08/27/2022 |
| Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2. | Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2.
Jang J, Cho EH, Cho Y, Ganzorig B, Kim KY, Kim MG, Kim C., Free PMC Article | 08/27/2022 |
| Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1. | Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1.
Yamashita F, Kaieda T, Shimomura T, Kawaguchi M, Lin CY, Johnson MD, Tanaka H, Kiwaki T, Fukushima T, Kataoka H. | 06/25/2022 |
| Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer. | Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer.
Dai YH, Wang YF, Shen PC, Lo CH, Yang JF, Lin CS, Chao HL, Huang WY., Free PMC Article | 10/23/2021 |
| Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function. | Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function.
Cho Y, Kim SB, Kim J, Pham AVQ, Yoon MJ, Park JH, Hwang KT, Park D, Cho Y, Kim MG, Kim C., Free PMC Article | 06/12/2021 |
| Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194. | Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194.
Kamble PR, Rane S, Breed AA, Joseph S, Mahale SD, Pathak BR. | 05/15/2021 |
| Insights into the regulation of the matriptase-prostasin proteolytic system. | Insights into the regulation of the matriptase-prostasin proteolytic system.
Holt-Danborg L, Skovbjerg S, Goderum KW, Nonboe AW, Stankevic E, Frost ÁK, Vitved L, Jensen JK, Vogel LK. | 03/13/2021 |
| Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins. | Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins.
Wu CJ, Lu M, Feng X, Nakato G, Udey MC., Free PMC Article | 02/27/2021 |
| A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CbetaII. | A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII.
Yoon J, Cho Y, Kim KY, Yoon MJ, Lee HS, Jeon SD, Cho Y, Kim C, Kim MG., Free PMC Article | 12/26/2020 |
| CDX2 has a dual function in regulating both ST14 and SPINT1, gene expression in intestinal cells. We find that CDX2 is not required for the basal ST14 and SPINT1 gene expression; however changes in CDX2 expression affects the ST14/SPINT1 mRNA ratio. | Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2.
Danielsen ET, Olsen AK, Coskun M, Nonboe AW, Larsen S, Dahlgaard K, Bennett EP, Mitchelmore C, Vogel LK, Troelsen JT., Free PMC Article | 10/26/2019 |
| Results indicate that Kunitz Domain I (KD1) of hepatocyte growth factor activator inhibitor-2 (HAI-2) plays a major role in the inhibition of cellular matritptase activation as well as prostate cancer motility. | The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.
Wu SR, Teng CH, Tu YT, Ko CJ, Cheng TS, Lan SW, Lin HY, Lin HH, Tu HF, Hsiao PW, Huang HP, Chen CH, Lee MS., Free PMC Article | 07/13/2019 |
| Our findings suggest that the high stromal matriptase expression was strongly associated with tumor progression, recurrence and poor outcomes in patients with extrahepatic bile duct cancer. | Overexpression of matriptase in tumor stroma is a poor prognostic indicator of extrahepatic bile duct cancer.
Komatsubara T, Oshiro H, Sakuma Y, Sata N, Niki T, Fukushima N. | 03/23/2019 |
| used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of cytoskeletal and ECM peptides to the ST14 protease; Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme. | Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme.
Zaman S, Chobrutskiy BI, Patel JS, Callahan BM, Tong WL, Blanck G. | 01/19/2019 |
| the data strongly advocate this ST14 variant as the underlying genetic cause of autosomal recessive ichthyosis with hypotrichosis syndrome in this first reported affected family from Pakistan. Moreover, the present study adds to the spectrum of mutations in the ST14 gene, implicating them in the pathogenesis of autosomal recessive ichthyosis with hypotrichosis syndrome. | A disease-causing novel missense mutation in the ST14 gene underlies autosomal recessive ichthyosis with hypotrichosis syndrome in a consanguineous family.
Ahmad F, Ahmed I, Nasir A, Umair M, Shahzad S, Muhammad D, Santos-Cortez RLP, Leal SM, Ahmad W., Free PMC Article | 09/1/2018 |
| limited role for HAI-2 in the inhibition of matriptase and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase | Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin.
Lee SP, Kao CY, Chang SC, Chiu YL, Chen YJ, Chen MG, Chang CC, Lin YW, Chiang CP, Wang JK, Lin CY, Johnson MD., Free PMC Article | 04/14/2018 |
| Abrogation of matriptase expression by silencing with RNAi or inhibition of matriptase proteolytic activity with a synthetic inhibitor impairs the conversion of inactive pro-HGF to active HGF and subsequent c-Met-mediated signaling. | Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.
Zoratti GL, Tanabe LM, Hyland TE, Duhaime MJ, Colombo É, Leduc R, Marsault E, Johnson MD, Lin CY, Boerner J, Lang JE, List K., Free PMC Article | 02/24/2018 |
| Data, including data from studies using cadaver tissue, suggest that matriptase and matriptase mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase RNA are expressed in young individuals as compared to older individuals; matriptase cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102). | The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide.
Lanchec E, Désilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, Gris D, Leduc R, Lavoie C., Free PMC Article | 01/27/2018 |
| Activation of proHGF by St14 induces mouse embryonic stem cell differentiation. | Activation of proHGF by St14 induces mouse embryonic stem cell differentiation.
Yan X, Xue Y, Zhou Y, Cheng Y, Yin S, Ma Q, Zeng F., Free PMC Article | 01/13/2018 |
| The authors report that ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 is not applicable. | Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer.
Kim S, Yang JW, Kim C, Kim MG., Free PMC Article | 12/30/2017 |
| These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated. | Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.
Wu CJ, Feng X, Lu M, Morimura S, Udey MC., Free PMC Article | 09/9/2017 |
| Matriptase is present in macrophages from patients with mutated alpha-1 antitrypsin at high levels and contributes to their proteolytic activity on extracellular matrix. MMP-14 is a novel substrate for matriptase, which regulates the levels of MMP-14 on the cell surface. High levels of matriptase may contribute to increased ECM degradation by Z-M, both directly and through MMP-14 activation. | Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.
Krotova K, Marek GW, Wang RL, Aslanidi G, Hoffman BE, Khodayari N, Rouhani FN, Brantly ML., Free PMC Article | 08/19/2017 |
| Ultraviolet irradiation/reactive oxygen species induced matriptase proteolysis may have short term protective effects and contribute to the recovery from acute epidermal damage and/or pathology of skin with chronic sun damage. | Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death.
Chen CY, Chen CJ, Lai CH, Wu BY, Lee SP, Johnson MD, Lin CY, Wang JK. | 05/13/2017 |
| The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis. | Decreasing the ratio of matriptase/HAI‑1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.
Sun P, Jiang Z, Chen X, Xue L, Mao X, Ruan G, Song Y, Mustea A., Free PMC Article | 04/8/2017 |
| Given that matriptase-1 participates in terminal KC differentiation, its absence in psoriatic skin lesions indicates that this contributes to the barrier disturbances in this disease. | Matriptase-1 expression is lost in psoriatic skin lesions and is downregulated by TNFα in vitro.
Mildner M, Bauer R, Mlitz V, Ballaun C, Tschachler E. | 08/13/2016 |