| Overexpressing of the GIPC1 protects against pathological cardiac remodelling. | Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Sun X, Han Y, Yu Y, Chen Y, Dong C, Lv Y, Qu H, Fan Z, Yu Y, Sang Y, Tang W, Liu Y, Ju J, Zhao D, Bai Y. | 04/25/2024 |
| GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling. | GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.
Li T, Zhong W, Yang L, Zhao Z, Wang LI, Liu C, Li W, Lv H, Wang S, Yan J, Wu T, Song G, Luo F., Free PMC Article | 01/12/2024 |
| Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport. | Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport.
Ramonett A, Kwak EA, Ahmed T, Flores PC, Ortiz HR, Lee YS, Vanderah TW, Largent-Milnes T, Kashatus DF, Langlais PR, Mythreye K, Lee NY., Free PMC Article | 03/26/2022 |
| GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array. | Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Shang G, Brautigam CA, Chen R, Lu D, Torres-Vázquez J, Zhang X., Free PMC Article | 02/24/2018 |
| Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells. | The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.
La Torre A, Hoshino A, Cavanaugh C, Ware CB, Reh TA., Free PMC Article | 07/30/2016 |
| Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages. | An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.
Zamzow DR, Elias V, Shumaker M, Larson C, Magnusson KR., Free PMC Article | 10/19/2013 |
| findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization | Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.
Giese AP, Ezan J, Wang L, Lasvaux L, Lembo F, Mazzocco C, Richard E, Reboul J, Borg JP, Kelley MW, Sans N, Brigande J, Montcouquiol M., Free PMC Article | 12/8/2012 |
| TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice | The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV., Free PMC Article | 11/24/2012 |
| GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. | GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.
Wu D, Haruta A, Wei Q., Free PMC Article | 10/23/2010 |
| Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha. | Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M., Free PMC Article | 01/21/2010 |
| synectin deficiency results in increased degradation of PDGF-BB protein in arterial endothelial cell and, consequently, reduced recruitment of mural cells to newly forming arteries | Synectin-dependent regulation of arterial maturation.
Paye JM, Phng LK, Lanahan AA, Gerhard H, Simons M., Free PMC Article | 01/21/2010 |
| Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC | Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
Lee NY, Ray B, How T, Blobe GC., Free PMC Article | 01/21/2010 |
| Plays a role in arteriolar development. | Synectin/syndecan-4 regulate coronary arteriolar growth during development.
Dedkov EI, Thomas MT, Sonka M, Yang F, Chittenden TW, Rhodes JM, Simons M, Ritman EL, Tomanek RJ. | 01/21/2010 |
| Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling. | Characterization of synectin expression and promoter activity.
Zhang Y, Chittenden T, Simons M. | 01/21/2010 |
| Synectin selectively regulates arterial branching morphogenesis. | Selective regulation of arterial branching morphogenesis by synectin.
Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M. | 01/21/2010 |
| Results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity. | BDNF-mediated neurotransmission relies upon a myosin VI motor complex.
Yano H, Ninan I, Zhang H, Milner TA, Arancio O, Chao MV. | 01/21/2010 |
| a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ-binding motif drastically reduced GIPC/synectin and myosin VI recruitment to endocytic vesicles | Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.
Naccache SN, Hasson T, Horowitz A., Free PMC Article | 01/21/2010 |
| results confirm synectin involvement in FGF2-dependent signal transduction and provide insights into synectin-dependent gene expression in the endothelium | Synectin-dependent gene expression in endothelial cells.
Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M. | 01/21/2010 |