| GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. | GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
Xie YK, Luo H, Zhang SX, Chen XY, Guo R, Qiu XY, Liu S, Wu H, Chen WB, Zhen XH, Ma Q, Tian JL, Li S, Chen X, Han Q, Duan S, Shen C, Yang F, Xu ZZ. | 04/23/2022 |
| Epithelial Wntless regulates postnatal alveologenesis. | Epithelial Wntless regulates postnatal alveologenesis.
Fang Y, Shao H, Wu Q, Wong NC, Tsong N, Sime PJ, Que J., Free PMC Article | 02/12/2022 |
| Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. | Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.
Liu S, Tang L, Zhao X, Nguyen B, Heallen TR, Li M, Wang J, Wang J, Martin JF., Free PMC Article | 01/15/2022 |
| The function of Wls in ovarian development. | The function of Wls in ovarian development.
Chen L, Zhang W, Huang R, Miao X, Li J, Yu D, Li Y, Hsu W, Qiu M, Zhang Z, Li F. | 08/14/2021 |
| Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction. | Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.
Bagchi DP, Li Z, Corsa CA, Hardij J, Mori H, Learman BS, Lewis KT, Schill RL, Romanelli SM, MacDougald OA., Free PMC Article | 07/10/2021 |
| Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility. | Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility.
Cheng J, Li Y, Zhang Y, Wang X, Sun F, Liu Y., Free PMC Article | 05/8/2021 |
| Data show that epithelial Wntless was required for the growth and differentiation of small intestinal organoids but not in live animals. | Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models.
Gao G, Wei G, Liu S, Chen J, Zeng Z, Zhang X, Chen F, Zhuo L, Hsu W, Li D, Liu M, Zhang X., Free PMC Article | 06/27/2020 |
| Deletion of WLS in peritubular myoid cells is not essential for male fertility in mice. | Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice.
Wang YQ, Chen SR, Liu YX. | 09/14/2019 |
| Data show that Shh-Cre-mediated deletion of Wntless, the Wnt cargo protein, in mouse posterior limb mesenchyme causes bone syndactyly of the 3rd and 4th digits, resembling the human Malik-Percin type . Wntless(Shh-Cre) limbs displayed altered expression of hedgehog pathway genes and impaired noncanonical Wnt signaling activity. | Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly.
Zhu XJ, Fang Y, Xiong Y, Wang M, Yang X, Li Y, Zhang X, Dai ZM, Qiu M, Zhang Z, Zhang Z. | 01/12/2019 |
| WLS role in the principal cells of the caput epididymidis during sperm maturation | Role of WNT signaling in epididymal sperm maturation.
Cheng JM, Tang JX, Li J, Wang YQ, Wang XX, Zhang Y, Chen SR, Liu YX., Free PMC Article | 09/22/2018 |
| Wntless-deficient macrophages presented a unique subset of M2-like macrophages with anti-inflammatory, reparative, and angiogenic properties. Serial echocardiography studies revealed that mice lacking macrophage Wnt secretion showed improved function and less remodeling 30 days after myocardial infarction. | Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice.
Palevski D, Levin-Kotler LP, Kain D, Naftali-Shani N, Landa N, Ben-Mordechai T, Konfino T, Holbova R, Molotski N, Rosin-Arbesfeld R, Lang RA, Leor J., Free PMC Article | 01/13/2018 |
| GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner. | Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.
Chen SR, Tang JX, Cheng JM, Hao XX, Wang YQ, Wang XX, Liu YX., Free PMC Article | 10/14/2017 |
| these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt ligands. | Gpr177-mediated Wnt Signaling is Required for Fungiform Placode Initiation.
Zhu X, Liu Y, Zhao P, Dai Z, Yang X, Li Y, Qiu M, Zhang Z. | 07/30/2016 |
| regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt signaling | Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.
Zhong ZA, Zahatnansky J, Snider J, Van Wieren E, Diegel CR, Williams BO., Free PMC Article | 07/16/2016 |
| Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance. | Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than HSCs maintenance.
Cao J, Zhang L, Wan Y, Li H, Zhou R, Ding H, Liu Y, Yao Z, Guo X. | 11/28/2015 |
| Wls-mediated secretion of Wnt ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall. | Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.
Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D., Free PMC Article | 08/8/2015 |
| eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt activity, leading to inhibition of odontoblast maturation and root elongation. | Wntless regulates dentin apposition and root elongation in the mandibular molar.
Bae CH, Kim TH, Ko SO, Lee JC, Yang X, Cho ES., Free PMC Article | 05/30/2015 |
| The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1, and Pax6 in the rhombic lip provides novel views of early cerebellar development. | Wls provides a new compartmental view of the rhombic lip in mouse cerebellar development.
Yeung J, Ha TJ, Swanson DJ, Choi K, Tong Y, Goldowitz D., Free PMC Article | 01/10/2015 |
| Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium | Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.
de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC., Free PMC Article | 06/28/2014 |
| The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development. | Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.
Zhang L, Li H, Yu J, Cao J, Chen H, Zhao H, Zhao J, Yao Y, Cheng H, Wang L, Zhou R, Yao Z, Guo X. | 04/26/2014 |
| Gpr177 regulates pulmonary vasculature development. | Gpr177 regulates pulmonary vasculature development.
Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J., Free PMC Article | 11/2/2013 |
| Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis. | Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Augustin I, Gross J, Baumann D, Korn C, Kerr G, Grigoryan T, Mauch C, Birchmeier W, Boutros M., Free PMC Article | 11/2/2013 |
| Wnt production mediated by Gpr177 is essential for mammary morphogenesis. | Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis.
Maruyama EO, Yu HM, Jiang M, Fu J, Hsu W., Free PMC Article | 08/31/2013 |
| Wntless is necessary for respiratory epithelial cell differentiation. | Wntless is required for peripheral lung differentiation and pulmonary vascular development.
Cornett B, Snowball J, Varisco BM, Lang R, Whitsett J, Sinner D., Free PMC Article | 08/3/2013 |
| Here we report that Wnt production mediated by Gpr177, the mouse Wls ortholog, is essential for hair follicle induction. | Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.
Fu J, Hsu W., Free PMC Article | 05/11/2013 |