| Our findings support that ASB16-AS1 and SYN2 may represent two novel functional genes underlying bone mineral density variation | Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions.
Meng XH, Chen XD, Greenbaum J, Zeng Q, You SL, Xiao HM, Tan LJ, Deng HW., Free PMC Article | 05/18/2019 |
| These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. | DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.
Cruceanu C, Kutsarova E, Chen ES, Checknita DR, Nagy C, Lopez JP, Alda M, Rouleau GA, Turecki G., Free PMC Article | 06/10/2017 |
| Both GABRA6 and Synapsin II polymorphisms are important risk factors for the development of idiopathic generalized epilepsy in a South Indian population. | Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Prasad DK, Shaheen U, Satyanarayana U, Prabha TS, Jyothy A, Munshi A. | 04/25/2015 |
| Results identify SYN2 as a novel predisposing gene for autism spectrum disorders (ASD) and strengthen the hypothesis that a disturbance of synaptic homeostasis underlies ASD. | SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth.
Corradi A, Fadda M, Piton A, Patry L, Marte A, Rossi P, Cadieux-Dion M, Gauthier J, Lapointe L, Mottron L, Valtorta F, Rouleau GA, Fassio A, Benfenati F, Cossette P., Free PMC Article | 08/9/2014 |
| Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder | Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder.
Cruceanu C, Alda M, Grof P, Rouleau GA, Turecki G., Free PMC Article | 09/1/2012 |
| SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy in this case-control study and meta-analysis. | Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: a case-control study and meta-analysis.
Haerian BS, Lim KS, Tan HJ, Wong CP, Wong SW, Tan CT, Raymond AA, Mohamed Z. | 06/2/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Results from our study indicate the involvement of SYN2 gene polymorphism in conferring risk to epilepsy; however, the genetic variant does not seem to modulate drug-response in epilepsy pharmacotherapy. | Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.
Lakhan R, Kalita J, Misra UK, Kumari R, Mittal B, Lakhan R, Kalita J, Misra UK, Kumari R, Mittal B. | 06/28/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesVariation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators. Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.
Lakhan R, Kalita J, Misra UK, Kumari R, Mittal B, Lakhan R, Kalita J, Misra UK, Kumari R, Mittal B. | 01/20/2010 |
| A case-control study with synapsin II was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study. | No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.
Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L, Li S, Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L, Li S. | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.
Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D, Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.
Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L, Li S, Wang Y, Yu L, Zhao T, Xu J, Liu Z, Liu Y, Feng G, He L, Li S. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.
Lee HJ, Song JY, Kim JW, Jin SY, Hong MS, Park JK, Chung JH, Shibata H, Fukumaki Y. Positive association between synapsin II and schizophrenia.
Chen Q, He G, Wang XY, Chen QY, Liu XM, Gu ZZ, Liu J, Li KQ, Wang SJ, Zhu SM, Feng GY, He L, Chen Q, He G, Wang XY, Chen QY, Liu XM, Gu ZZ, Liu J, Li KQ, Wang SJ, Zhu SM, Feng GY, He L. | 03/13/2008 |
| Syn2 is likely to be involved in the etiology or pathogenesis of schizophrenia. | Association of synapsin 2 with schizophrenia in families of Northern European ancestry.
Saviouk V, Moreau MP, Tereshchenko IV, Brzustowicz LM., Free PMC Article | 01/21/2010 |
| synapsin II variants are associated with susceptibility to schizophrenia. | Family-based association study of synapsin II and schizophrenia.
Chen Q, He G, Qin W, Chen QY, Zhao XZ, Duan SW, Liu XM, Feng GY, Xu YF, St Clair D, Li M, Wang JH, Xing YL, Shi JG, He L., Free PMC Article | 01/21/2010 |
| This study suggests a positive association between synapsin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia. | Positive association between synapsin II and schizophrenia.
Chen Q, He G, Wang XY, Chen QY, Liu XM, Gu ZZ, Liu J, Li KQ, Wang SJ, Zhu SM, Feng GY, He L, Chen Q, He G, Wang XY, Chen QY, Liu XM, Gu ZZ, Liu J, Li KQ, Wang SJ, Zhu SM, Feng GY, He L. | 01/21/2010 |