| An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation. | An unexpected role of neurite outgrowth inhibitor A as regulator of tooth enamel formation.
Pagella P, Lai CF, Pirenne L, Cantù C, Schwab ME, Mitsiadis TA., Free PMC Article | 10/21/2024 |
| Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts. | Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y., Free PMC Article | 12/6/2023 |
| Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration. | Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration.
Sekine Y, Wang X, Kikkawa K, Honda S, Strittmatter SM., Free PMC Article | 11/8/2023 |
| Microglial Nogo delays recovery following traumatic brain injury in mice. | Microglial Nogo delays recovery following traumatic brain injury in mice.
Glotfelty EJ, Hsueh SC, Claybourne Q, Bedolla A, Kopp KO, Wallace T, Zheng B, Luo Y, Karlsson TE, McDevitt RA, Olson L, Greig NH., Free PMC Article | 08/7/2023 |
| Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway. | Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway.
Gong P, Jia HY, Li R, Ma Z, Si M, Qian C, Zhu FQ, Sheng-Yong L. | 06/21/2023 |
| Nogo-B deficiency suppresses white adipogenesis by regulating beta-catenin signaling. | Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J. | 04/12/2023 |
| Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease. | Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease.
Pavon MV, Navakkode S, Wong LW, Sajikumar S. | 01/11/2023 |
| Lack of Nogo-B expression ameliorates PPARgamma deficiency-aggravated liver fibrosis by regulating TLR4-NF-kappaB-TNF-alpha axis and macrophage polarization. | Lack of Nogo-B expression ameliorates PPARγ deficiency-aggravated liver fibrosis by regulating TLR4-NF-κB-TNF-α axis and macrophage polarization.
Zhao D, Xue C, Yang Y, Li J, Wang X, Chen Y, Zhang S, Chen Y, Duan Y, Yang X, Han J. | 09/24/2022 |
| MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4. | MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4.
Fan P, Zhang L, Cheng T, Wang J, Zhou J, Zhao L, Hua C, Xia Q. | 01/29/2022 |
| Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour. | Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour.
Koper-Lenkiewicz OM, Milewska AJ, Kamińska J, Sawicki K, Chrzanowski R, Zińczuk J, Reszeć J, Tylicka M, Matuszczak E, Matowicka-Karna J, Mariak Z, Mucha MW, Pawlak R, Dymicka-Piekarska V., Free PMC Article | 12/11/2021 |
| Nogo-A/S1PR2 Signaling Pathway Inactivation Decreases Microvascular Damage and Enhances Microvascular Regeneration in PDMCI Mice. | Nogo-A/S1PR2 Signaling Pathway Inactivation Decreases Microvascular Damage and Enhances Microvascular Regeneration in PDMCI Mice.
Tang H, Xu Y, Liu L, He L, Huang J, Pan J, He W, Wang Y, Yang X, Hou X, Xu K. | 08/21/2021 |
| Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. | Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y, Chen Y. | 02/6/2021 |
| A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration. | A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration.
Sekine Y, Lindborg JA, Strittmatter SM., Free PMC Article | 10/24/2020 |
| Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling. | Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling.
Orfila JE, Dietz RM, Rodgers KM, Dingman A, Patsos OP, Cruz-Torres I, Grewal H, Strnad F, Schroeder C, Herson PS., Free PMC Article | 09/26/2020 |
| n this study, we demonstrate that genetic deletion of the neurite outgrowth inhibitor Nogo-A or one of its corresponding receptors, S1PR2, improves vascular sprouting and repair and reduces neurological deficits after cerebral ischemia in mice | Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke.
Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME., Free PMC Article | 04/4/2020 |
| overexpression of sNogo-B in the circulation ameliorates diabetic kidney disease by reducing albuminuria, hyperfiltration, and abnormal angiogenesis and protecting glomerular capillary structure. Systemic sNogo-B overexpression in diabetic mice also associates with dampening vascular endothelial growth factor-A signaling and reducing endothelial nitric oxide synthase, AKT, and GSK3beta phosphorylation. | Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature.
Hernandez-Diaz I, Pan J, Ricciardi CA, Bai X, Ke J, White KE, Flaquer M, Fouli GE, Argunhan F, Hayward AE, Hou FF, Mann GE, Miao RQ, Long DA, Gnudi L., Free PMC Article | 03/21/2020 |
| Not only did supplementary Pgk1 enhance neurite outgrowth of motoneurons in defective cells, but injection of Pgk1 rescued denervation in muscle-specific NogoA-overexpression of zebrafish and an Amyotrophic Lateral Sclerosis mouse model, SOD1 G93A. | Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA.
Lin CY, Wu CL, Lee KZ, Chen YJ, Zhang PH, Chang CY, Harn HJ, Lin SZ, Tsai HJ., Free PMC Article | 02/1/2020 |
| Nogo-C regulates cardiac fibrosis through interacting with Sec61alpha to mediate the Ca(2+) leakage from endoplasmic reticulum. | Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca(2+) leakage channel Sec61α in mouse hearts.
Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M., Free PMC Article | 11/9/2019 |
| Nogo-A neutralization may promote visual recovery in retinal diseases such as glaucoma. | Nogo-A inactivation improves visual plasticity and recovery after retinal injury.
Mdzomba JB, Jordi N, Rodriguez L, Joly S, Bretzner F, Pernet V., Free PMC Article | 11/9/2019 |
| While Nogo-B depletion inhibited tumor angiogenesis, Nogo-B overexpression promoted tumor angiogenesis in a tumor xenograft subcutaneous model of hepatocellular carcinoma. | Nogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma.
Cai H, Saiyin H, Liu X, Han D, Ji G, Qin B, Zuo J, Shen S, Yu W, Wu J, Wu Y, Yu L., Free PMC Article | 08/24/2019 |
| Results demonstrate a marked upregulation of the Nogo-A receptor sphingosine 1-phosphate receptor 2 in blood vessels following oxygen-induced retinopathy, while Nogo-A is abundantly expressed in surrounding glial cells. Acute inhibition of Nogo-A with function-blocking antibody 11C7 significantly improved vascular regeneration and consequently prevented pathological pre-retinal angiogenesis. | Nogo-A inhibits vascular regeneration in ischemic retinopathy.
Joly S, Dejda A, Rodriguez L, Sapieha P, Pernet V. | 03/23/2019 |
| These data show for the first time with genetic evidence that Nogo specifically expressed by oligodendrocytes restricts compensatory sprouting after CNS injury. | Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury.
Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B., Free PMC Article | 03/9/2019 |
| Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits | Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.
Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J., Free PMC Article | 01/19/2019 |
| Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development | Axonal branching in lateral olfactory tract is promoted by Nogo signaling.
Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K., Free PMC Article | 08/18/2018 |
| NOGO-B/RTN4B and NOGO-A/RTN4A are simultaneously expressed in cultured epithelial, fibroblast and neuronal cells. Morphological analysis of cells with manipulated levels of NOGO-B/RTN4B revealed that it is required for maintenance of normal endoplasmic reticulum shape. | NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology.
Rämö O, Kumar D, Gucciardo E, Joensuu M, Saarekas M, Vihinen H, Belevich I, Smolander OP, Qian K, Auvinen P, Jokitalo E., Free PMC Article | 05/5/2018 |