| Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function. | Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function.
Zhou X, Fang X, Ithychanda SS, Wu T, Gu Y, Chen C, Wang L, Bogomolovas J, Qin J, Chen J., Free PMC Article | 08/22/2023 |
| Filamin C is Essential for mammalian myocardial integrity. | Filamin C is Essential for mammalian myocardial integrity.
Wu T, Xu Y, Zhang L, Liang Z, Zhou X, Evans SM, Chen J., Free PMC Article | 02/13/2023 |
| Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy. | Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy.
Powers JD, Kirkland NJ, Liu C, Razu SS, Fang X, Engler AJ, Chen J, McCulloch AD., Free PMC Article | 02/5/2022 |
| FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling. | FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling.
Knyazeva A, Khudiakov A, Vaz R, Muravyev A, Sukhareva K, Sejersen T, Kostareva A., Free PMC Article | 07/31/2021 |
| Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation. | Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
Schuld J, Orfanos Z, Chevessier F, Eggers B, Heil L, Uszkoreit J, Unger A, Kirfel G, van der Ven PFM, Marcus K, Linke WA, Clemen CS, Schröder R, Fürst DO., Free PMC Article | 06/5/2021 |
| Loss of Filamin C Is Catastrophic for Heart Function. | Loss of Filamin C Is Catastrophic for Heart Function.
Zhou Y, Chen Z, Zhang L, Zhu M, Tan C, Zhou X, Evans SM, Fang X, Feng W, Chen J., Free PMC Article | 11/21/2020 |
| HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC | HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
Juo LY, Liao WC, Shih YL, Yang BY, Liu AB, Yan YT., Free PMC Article | 01/14/2017 |
| The data of this study presented here provide further support that FLNC, a muscle-specific protein, could be a potential novel player in FTD pathogenesis. | Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.
Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, Ivanoiu A, Vandenbulcke M, Vandenberghe R, Cras P, De Deyn PP, Martin JJ, Maudsley S, Haass C, Cruts M, Van Broeckhoven C, Belgian Neurology (BELNEU) consortium., Free PMC Article | 05/28/2016 |
| Aciculin interacts with filamin C and Xin and is essential for myofibril assembly. | Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.
Molt S, Bührdel JB, Yakovlev S, Schein P, Orfanos Z, Kirfel G, Winter L, Wiche G, van der Ven PF, Rottbauer W, Just S, Belkin AM, Fürst DO. | 05/16/2015 |
| KY, IGFN1 and FLNC are part of a Z-band associated protein complex likely to provide structural support to the skeletal muscle sarcomere. | Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1.
Baker J, Riley G, Romero MR, Haynes AR, Hilton H, Simon M, Hancock J, Tateossian H, Ripoll VM, Blanco G. | 06/28/2010 |
| Cbl-associated protein provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity | Identification of CAP as a costameric protein that interacts with filamin C.
Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR., Free PMC Article | 01/21/2010 |
| MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 | Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
Fielitz J, van Rooij E, Spencer JA, Shelton JM, Latif S, van der Nagel R, Bezprozvannaya S, de Windt L, Richardson JA, Bassel-Duby R, Olson EN., Free PMC Article | 01/21/2010 |
| filamin C may function in signal transduction or cellular migration of the myogenic progenitor cell population | Myogenic progenitor cells express filamin C in developing and regenerating skeletal muscle.
Goetsch SC, Martin CM, Embree LJ, Garry DJ. | 01/21/2010 |
| These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure. | Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure.
Dalkilic I, Schienda J, Thompson TG, Kunkel LM., Free PMC Article | 01/21/2010 |