| Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain. | Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain.
Huang X, Deng J, Xu T, Xin W, Zhang Y, Ruan X., Free PMC Article | 11/22/2021 |
| acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus. | Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.
Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Radošević-Stašić B. | 04/22/2017 |
| observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats | Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain.
Scudiero R, Cigliano L, Verderame M. | 02/25/2017 |
| The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7. | Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
Tian T, Li LL, Zhang SQ, Ni H. | 01/28/2017 |
| Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons. | Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription.
Lin TB, Hsieh MC, Lai CY, Cheng JK, Wang HH, Chau YP, Chen GD, Peng HY. | 12/17/2016 |
| MT-I/II are required for the conditioning lesion effect and can promote axonal regeneration in the injured central nervous system. | Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT., Free PMC Article | 10/3/2015 |
| Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- beta in rat strains contributed to different susceptibilities to experimental autoimmune encephalomyelitis. | Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- β in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis.
Grubić-Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Milin C, Radošević-Stašić B., Free PMC Article | 08/9/2014 |
| Data suggest magnesium deficiency enhances liver zinc uptake by up-regulating expression of Zip14/Slc39a14 (solute carrier family 39, member 14); increased liver content of zinc leads to up-regulation of expression of metallothioneins (Mt1 and Mt2). | Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.
Kotani M, Kim KH, Ishizaki N, Funaba M, Matsui T. | 05/31/2014 |
| endogenous MT-I/II might play an important role in the pathogenesis of pain behaviors, participating in the initiation of inflammatory and neuropathic pain rather than in their maintenance | Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models.
Kwon A, Jeon SM, Hwang SH, Kim JH, Cho HJ. | 02/8/2014 |
| Metallothionein-2 expression is regulated by psychological stress in adult male and female rats. | Glucocorticoids regulate metallothionein-1/2 expression in rat choroid plexus: effects on apoptosis.
Martinho A, Gonçalves I, Santos CR. | 10/19/2013 |
| Zinc pre-treatment improved MT-1 and MT-2 gene expressions in kidney which significantly alleviated acute toxicity of depleted uranium. | The protective role of zinc against acute toxicity of depleted uranium in rats.
Hao Y, Ren J, Liu J, Luo S, Ma T, Li R, Su Y. | 04/27/2013 |
| The MT mRNA level displays isoform-specific changes: those of MT-1 do not change appreciably, whereas those of MT-2 increase significantly in 2-hr endotoxemia, with or without obstructive jaundice. | Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice.
Abrahám S, Hermesz E, Szabó A, Ferencz A, Jancsó Z, Duda E, Abrahám M, Lázár G, Lázár G Jr. | 03/3/2012 |
| Expression of MT2 in the adult rat testes and during development | Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development.
Izzo G, Francesco A, Ferrara D, Campitiello MR, Serino I, Minucci S, d'Istria M. | 10/30/2010 |
| The solution structures of Cd(3)-thiolate cluster containing beta-domain of mouse beta-MT-1 and rat beta-MT-2 show high structural similarities, but widely differing structure dynamics. | Influence of NH-Sgamma bonding interactions on the structure and dynamics of metallothioneins.
Romero-Isart N, Oliva B, Vasák M. | 05/3/2010 |
| Results provide evidence for the heterogeneous distribution of MT(2) receptors in different parts and layers of the gastrointestinal tract, which could indicate a physiological role of melatonin in the gastrointestinal tract. | Immunohistochemical definition of MT(2) receptors and melatonin in the gastrointestinal tissues of rat.
Stebelová K, Anttila K, Mänttäri S, Saarela S, Zeman M. | 03/8/2010 |
| TTR-MT1/2 complexes may be functionally significant not only in healthy conditions but also in Abeta deposition in Alzheimer disease. | Transthyretin interacts with metallothionein 2.
Gonçalves I, Quintela T, Baltazar G, Almeida MR, Saraiva MJ, Santos CR. | 01/21/2010 |