| Gene-gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy. | Gene-gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy.
Lin ZJ, He JW, Zhu SY, Xue LH, Zheng JF, Zheng LQ, Huang BX, Chen GZ, Lin PX. | 06/3/2024 |
| Assessment of Bcl-xL, TAX, and HBZ Gene Expression in Adult T cell Leukemia/Lymphoma Patients. | Assessment of Bcl-xL, TAX, and HBZ Gene Expression in Adult T cell Leukemia/Lymphoma Patients.
Fajami Z, Akbarin MM, Rafatpanah H, Ramezani S, Rahimi H, Rezaee SA. | 03/13/2024 |
| The molecular mechanism of gamma-aminobutyric acid against AD: the role of CEBPalpha/circAPLP2/miR-671-5p in regulating CNTN1/2 expression. | The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression.
Meng N, Pan P, Hu S, Miao C, Hu Y, Wang F, Zhang J, An L. | 02/27/2023 |
| Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies. | Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies.
Chatterjee M, van Steenoven I, Huisman E, Oosterveld L, Berendse H, van der Flier WM, Del Campo M, Lemstra AW, van de Berg WDJ, Teunissen CE., Free PMC Article | 06/19/2021 |
| Cord blood exosomal CNTN2 is an attractive candidate for further determination as a molecular marker for neonates at risk for brain iron deficiency, particularly for male neonates. | Cord Blood-Derived Exosomal CNTN2 and BDNF: Potential Molecular Markers for Brain Health of Neonates at Risk for Iron Deficiency.
Marell PS, Blohowiak SE, Evans MD, Georgieff MK, Kling PJ, Tran PV., Free PMC Article | 03/21/2020 |
| The strongest associations between protein abundance and Alzheimer's disease severity were found for APLP1, CNTN2 and SPP1 proteins | Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.
Begcevic I, Brinc D, Brown M, Martinez-Morillo E, Goldhardt O, Grimmer T, Magdolen V, Batruch I, Diamandis EP. | 10/26/2019 |
| The data of this study reveal that the contactin-2 changes observed in tissues are reflected in CSF, suggesting that decreased contactin-2 CSF levels might be a biomarker reflecting synaptic or axonal loss. | Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.
Chatterjee M, Del Campo M, Morrema THJ, de Waal M, van der Flier WM, Hoozemans JJM, Teunissen CE., Free PMC Article | 08/3/2019 |
| the selective distribution of Caspr2 and TAG-1 may be regulated, allowing them to modulate the strategic function of the Kv1 complex along axons | The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons.
Pinatel D, Hivert B, Saint-Martin M, Noraz N, Savvaki M, Karagogeos D, Faivre-Sarrailh C. | 03/31/2018 |
| the ectodomains of CNTNAP2 and contactin 2 (CNTN2) bind directly and specifically, with low nanomolar affinity. | Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2).
Lu Z, Reddy MV, Liu J, Kalichava A, Liu J, Zhang L, Chen F, Wang Y, Holthauzen LM, White MA, Seshadrinathan S, Zhong X, Ren G, Rudenko G., Free PMC Article | 05/27/2017 |
| RACK1 interacts with CNTN2, and the effects of RACK1 on glioma cell growth and differentiation are mediated by CNTN2. | RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway.
Yan Y, Jiang Y. | 10/22/2016 |
| Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1 | BACE1 activity regulates cell surface contactin-2 levels.
Gautam V, D'Avanzo C, Hebisch M, Kovacs DM, Kim DY., Free PMC Article | 09/13/2014 |
| A single nucleotide deletion in exon 6 of CNTN2 results in a frameshift mutation, segregating in a recessive manner in a consanguineous Egyptian family with epilepsy. | Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2.
Stogmann E, Reinthaler E, Eltawil S, El Etribi MA, Hemeda M, El Nahhas N, Gaber AM, Fouad A, Edris S, Benet-Pages A, Eck SH, Pataraia E, Mei D, Brice A, Lesage S, Guerrini R, Zimprich F, Strom TM, Zimprich A. | 06/1/2013 |
| The single-nucleotide polymorphism (SNP) rs2275697 in the TAG-) gene was not associated with treatment responsiveness, treatment dependence, disability, or mortality in chronic inflammatory demyelinating polyneuropathy | Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy.
Pang SY, Chan KH, Mak WW, Kung MH, Lee CN, Tsoi TH, Yip EK, Ho SL. | 08/25/2012 |
| allelic variation in TAG-1 does not play a major role in determining multifocal motor neuropathy susceptibility. | Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes.
Vlam L, Cats EA, Seelen M, van Vught PW, van den Berg LH, van der Pol WL. | 03/10/2012 |
| single nucleotide polymorphisms in TAG-1 are related to the IVIg responsiveness of Chronic inflammatory demyelinating polyneuropathy patients. | Polymorphism of transient axonal glycoprotein-1 in chronic inflammatory demyelinating polyneuropathy.
Iijima M, Koike H, Katsuno M, Sobue G. | 11/5/2011 |
| immune response to CNTN2 and possible involvement in multiple sclerosis and EAE [REVIEW] | The gray aspects of white matter disease in multiple sclerosis.
Steinman L., Free PMC Article | 01/21/2010 |
| Contactin-2 is expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides; is an autoantigen targeted by T cells and autoantibodies in MS. | Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.
Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C, Meinl E., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesSingle nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.
Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. | 01/11/2009 |
| TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog. | The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.
Mörtl M, Sonderegger P, Diederichs K, Welte W., Free PMC Article | 01/21/2010 |
| The domains responsible for the neurite outgrowth promoting activity of TAG-1 have been investigated as well as its interactions with other cell adhesion molecules. | Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members.
Pavlou O, Theodorakis K, Falk J, Kutsche M, Schachner M, Faivre-Sarrailh C, Karagogeos D. | 01/21/2010 |