| T-box transcription factor 2 mediates antitumor immune response in cutaneous squamous cell carcinoma by regulating the expression of programmed death ligand 1. | T-box transcription factor 2 mediates antitumor immune response in cutaneous squamous cell carcinoma by regulating the expression of programmed death ligand 1.
Wang X, Li Z, Sun Y., Free PMC Article | 02/4/2023 |
| A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes. | A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes.
Zhou R, Liang J, Chen Q, Tian H, Yang C, Liu C. | 01/14/2023 |
| T-Box Transcription Factor 2 Enhances Chemoresistance of Endometrial Cancer by Mediating NRF2 Expression. | T-Box Transcription Factor 2 Enhances Chemoresistance of Endometrial Cancer by Mediating NRF2 Expression.
Ding N, Zhang T, Yu X, Zhuang S. | 11/5/2022 |
| Clinical and Genetic Characteristics of Preeclampsia. | Clinical and Genetic Characteristics of Preeclampsia.
Golovchenko OV, Abramova MY, Orlova VS, Batlutskaya IV, Sorokina IN., Free PMC Article | 08/6/2022 |
| TBX2, a Novel Regulator of Labour. | TBX2, a Novel Regulator of Labour.
Fernando F, Veenboer GJM, Oudijk MA, Kampman MAM, Heida KY, Lagendijk LJM, van der Post JAM, Jongejan A, Afink GB, Ris-Stalpers C., Free PMC Article | 07/10/2021 |
| MicroRNA-7 targets T-Box 2 to inhibit epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme. | MicroRNA-7 targets T-Box 2 to inhibit epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme.
Pan CM, Chan KH, Chen CH, Jan CI, Liu MC, Lin CM, Cho DY, Tsai WC, Chu YT, Cheng CH, Chuang HY, Chiu SC. | 03/28/2021 |
| Clinical significance of TBX2 in esophageal squamous cell carcinomas and its role in cell migration and invasion. | Clinical significance of TBX2 in esophageal squamous cell carcinomas and its role in cell migration and invasion.
Hu R, Deng J, Li C, Xu C, Cui ZH, Zhao J. | 03/20/2021 |
| T allele of rs59382073 in TBX2 3'UTR contributes to greater congenital heart defects risk in the Han Chinese population | Susceptibility to congenital heart defects associated with a polymorphism in TBX2 3' untranslated region in the Han Chinese population.
Wang J, Zhang RR, Cai K, Yang Q, Duan WY, Zhao JY, Gui YH, Wang F. | 06/13/2020 |
| data demonstrate that TBX2 promotes suppression of normal growth control mechanisms through recruitment of a large repression complex to EGR1-responsive promoters leading to the uncontrolled proliferation of breast cancer cells | TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells.
Crawford NT, McIntyre AJ, McCormick A, D'Costa ZC, Buckley NE, Mullan PB., Free PMC Article | 02/15/2020 |
| The minor C allele of rs4455026 in TBX2 promoter region was related with lower congenital heart disease susceptibility in the Han Chinese population via repressing its transcriptional activity. | A regulatory variant in TBX2 promoter is related to the decreased susceptibility of congenital heart disease in the Han Chinese population.
Zhang RR, Cai K, Liu L, Yang Q, Zhang P, Gui YH, Wang F., Free PMC Article | 04/13/2019 |
| transcription factor TBX2 is able to restrain ADAM10 gene expression and that this mechanism might play a role in regulating cellular processes in health, development and disease. | Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K., Free PMC Article | 03/16/2019 |
| We report four individuals with an overlapping spectrum of craniofacial dysmorphisms, cardiac anomalies, skeletal malformations, immune deficiency, endocrine abnormalities and developmental impairments, reminiscent of DiGeorge syndrome, who are heterozygotes for TBX2 variants. | Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.
Liu N, Schoch K, Luo X, Pena LDM, Bhavana VH, Kukolich MK, Stringer S, Powis Z, Radtke K, Mroske C, Deak KL, McDonald MT, McConkie-Rosell A, Markert ML, Kranz PG, Stong N, Need AC, Bick D, Amaral MD, Worthey EA, Levy S, Undiagnosed Diseases Network (UDN), Wangler MF, Bellen HJ, Shashi V, Yamamoto S., Free PMC Article | 03/16/2019 |
| Our results indicate that the R608W and R616Q variants of TBX2 as well as the A192T and A562V variants of TBX3 contribute to Conotruncal heart defects (CTDs)etiology; this was the first association of variants of TBX2 and TBX3 to CTDs based on a large population. | Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing.
Xie H, Zhang E, Hong N, Fu Q, Li F, Chen S, Yu Y, Sun K., Free PMC Article | 02/2/2019 |
| TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets. | TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Decaesteker B, Denecker G, Van Neste C, Dolman EM, Van Loocke W, Gartlgruber M, Nunes C, De Vloed F, Depuydt P, Verboom K, Rombaut D, Loontiens S, De Wyn J, Kholosy WM, Koopmans B, Essing AHW, Herrmann C, Dreidax D, Durinck K, Deforce D, Van Nieuwerburgh F, Henssen A, Versteeg R, Boeva V, Schleiermacher G, van Nes J, Mestdagh P, Vanhauwaert S, Schulte JH, Westermann F, Molenaar JJ, De Preter K, Speleman F., Free PMC Article | 12/22/2018 |
| The results indicated that the expression rates of TBX2 were significantly increased in the prostate cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade. | Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells.
Du WL, Fang Q, Chen Y, Teng JW, Xiao YS, Xie P, Jin B, Wang JQ., Free PMC Article | 06/9/2018 |
| TBX2 is a central component of the PTEN/PI3K/AKT signaling pathway deregulation in RMS cells and that targeting TBX2 in RMS tumors may offer a novel therapeutic approach for RMS | TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle.
Zhu B, Zhang M, Williams EM, Keller C, Mansoor A, Davie JK., Free PMC Article | 08/19/2017 |
| this new molecular-grade based on the combination of TBX2 and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer. | Stratification based on methylation of TBX2 and TBX3 into three molecular grades predicts progression in patients with pTa-bladder cancer.
Beukers W, Kandimalla R, Masius RG, Vermeij M, Kranse R, van Leenders GJ, Zwarthoff EC. | 03/26/2016 |
| Our results suggest a conserved role of Tbx2-related proteins in cell invasion and metastasis-related processes | The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases.
Shen J, Lu J, Sui L, Wang D, Yin M, Hoffmann I, Legler A, Pflugfelder GO., Free PMC Article | 10/24/2015 |
| Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1) is mediated by T-box transcription factor TBX3. | The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.
Li J, Ballim D, Rodriguez M, Cui R, Goding CR, Teng H, Prince S., Free PMC Article | 04/25/2015 |
| The data suggested that the DNA sequence variants within the TBX2 gene promoter was implicated in the indirect inguinal hernia development as a rare cause. | Genetic analysis of the TBX2 gene promoter in indirect inguinal hernia.
Zhang Y, Han Q, Fan H, Li W, Xing Q, Yan B. | 01/31/2015 |
| High TBX2 expression is associated with breast cancer. | TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB., Free PMC Article | 01/24/2015 |
| High TBX2 expression is associated with non-small cell lung cancer. | High TBX2 expression predicts poor prognosis in non-small cell lung cancer.
Zhang Z, Guo Y. | 09/27/2014 |
| TBX2 was a significantly prognostic factor for decreased survival. | Increased expression of TBX2 is a novel independent prognostic biomarker of a worse outcome in colorectal cancer patients after curative surgery and a potential therapeutic target.
Han Y, Tu WW, Wen YG, Yan DW, Qiu GQ, Peng ZH, Zhou CZ. | 09/6/2014 |
| deregulated TBX2 serves as an oncogene in rhabdomyosarcoma | TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Zhu B, Zhang M, Byrum SD, Tackett AJ, Davie JK., Free PMC Article | 08/9/2014 |
| Knocking down TBX2 sensitises the cells to cisplatin by disrupting the ATM-CHK2-p53 signalling pathway. | A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance.
Wansleben S, Davis E, Peres J, Prince S., Free PMC Article | 03/15/2014 |