| Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. | Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
Zhang Z, Wu Y, Fu J, Yu X, Su Y, Jia S, Cheng H, Shen Y, He X, Ren K, Zheng X, Guan H, Rao F, Zhao L., Free PMC Article | 08/8/2024 |
| Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. | Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.
Deng S, Lu X, Wang X, Liang B, Xu H, Yang D, Cui G, Yonemura A, Paine H, Zhou Y, Zhang Y, Simile MM, Urigo F, Evert M, Calvisi DF, Green BL, Chen X., Free PMC Article | 07/11/2024 |
| Suppressed Cellular Senescence Mediated by T-box3 in Aged Gastric Epithelial Cells may Contribute to Aging-related Carcinogenesis. | Suppressed Cellular Senescence Mediated by T-box3 in Aged Gastric Epithelial Cells may Contribute to Aging-related Carcinogenesis.
Takeuchi A, Asano N, Imatani A, Saito M, Jin X, Saito M, Kanno T, Hatta W, Uno K, Koike T, Masamune A., Free PMC Article | 07/31/2023 |
| Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments. | Intracellular mechanics and TBX3 expression jointly dictate the spreading mode of melanoma cells in 3D environments.
Higgins G, Higgins F, Peres J, Lang DM, Abdalrahman T, Zaman MH, Prince S, Franz T. | 06/1/2023 |
| TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling. | TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling.
Khan SF, Burmeister CA, Scott DJ, Sinkala M, Ramburan A, Wu HT, Schäfer G, Katz AA, Prince S. | 04/7/2023 |
| TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration. | TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration.
Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I, Allgöwer C, Mulaw M, Zengerling F, Günes C, Lickert H, Christoffels VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer L, Kleger A., Free PMC Article | 03/29/2023 |
| TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration. | TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration.
Wu L, Su C, Yang C, Liu J, Ye Y., Free PMC Article | 02/14/2023 |
| TBX3 stimulates proliferation and stem cell self-renewal in bladder carcinoma. | TBX3 stimulates proliferation and stem cell self-renewal in bladder carcinoma.
Huang L, Shao W, Wang X, Li F, Mao W. | 01/28/2023 |
| Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. | Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset.
Shi X, Zhuang Y, Chen Z, Xu M, Kuang J, Sun XL, Gao L, Kuang X, Zhang H, Li W, Wong SZH, Liu C, Liu L, Jiang D, Pei D, Lin Y, Wu QF., Free PMC Article | 11/26/2022 |
| TBX3 activating PVT1 accelerates proliferation, migration, and invasion by modulating the miR-30a/LOX axis in anaplastic thyroid carcinoma. | TBX3 activating PVT1 accelerates proliferation, migration, and invasion by modulating the miR-30a/LOX axis in anaplastic thyroid carcinoma.
Wen J, Zhang W, Zhou Y, Hu X, Luo L, Zhou J, Shi L, Zhou S. | 09/10/2022 |
| Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells. | Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells.
Mukherjee S, French DL, Gadue P., Free PMC Article | 03/19/2022 |
| A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells. | A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cells.
Bhat-Nakshatri P, Gao H, Sheng L, McGuire PC, Xuei X, Wan J, Liu Y, Althouse SK, Colter A, Sandusky G, Storniolo AM, Nakshatri H., Free PMC Article | 02/26/2022 |
| TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF. | TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF.
Peres J, Damerell V, Chauhan J, Popovic A, Desprez PY, Galibert MD, Goding CR, Prince S. | 12/18/2021 |
| TBX3 induces biased differentiation of human induced pluripotent stem cells into cardiac pacemaker-like cells. | TBX3 induces biased differentiation of human induced pluripotent stem cells into cardiac pacemaker-like cells.
Yan Y, Liu F, Dang X, Zhou R, Liao B. | 12/18/2021 |
| TBX3 and TBX5 duplication: A family with an atypical overlapping Holt-Oram/ulnar-mammary syndrome phenotype. | TBX3 and TBX5 duplication: A family with an atypical overlapping Holt-Oram/ulnar-mammary syndrome phenotype.
Cenni C, Andres S, Hempel M, Strom TM, Thomas E, Davies A, Timoney N, Frigiola A, Logan M, Holder-Espinasse M. | 08/14/2021 |
| Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. | Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
Cai J, Drewry MD, Perkumas K, Dismuke WM, Hauser MA, Stamer WD, Liu Y., Free PMC Article | 07/3/2021 |
| USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57(KIP2) repression. | USP7 promotes proliferation of papillary thyroid carcinoma cells through TBX3-mediated p57(KIP2) repression.
Xie P, Wang H, Xie J, Huang Z, Chen S, Cheng X, Zhang X, Liu F, Li Y, Huang D. | 07/3/2021 |
| Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer. | Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott IC, Christoffels VM., Free PMC Article | 05/29/2021 |
| Transcription box3 protects human umbilical vein endothelial cells in a highglucose environment through sirtuin 1/AKT signaling. | Transcription box‑3 protects human umbilical vein endothelial cells in a high‑glucose environment through sirtuin 1/AKT signaling.
Yu Z, Zhang W, Zhang X, Xu D, Wang N., Free PMC Article | 04/17/2021 |
| Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells. | Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells.
Zhao H, Wang F, Zhang W, Yang M, Tang Y, Wang X, Zhao Q, Huang C. | 03/20/2021 |
| A de novo TBX3 mutation presenting as dorsalization of the little fingers: A forme fruste phenotype of ulnar-mammary syndrome. | A de novo TBX3 mutation presenting as dorsalization of the little fingers: A forme fruste phenotype of ulnar-mammary syndrome.
Al-Qattan MM, Maddirevula S, Alkuraya FS. | 10/3/2020 |
| Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis. | Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.
Krstic M, Hassan HM, Kolendowski B, Hague MN, Anborgh PH, Postenka CO, Torchia J, Chambers AF, Tuck AB., Free PMC Article | 09/26/2020 |
| TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-beta1/Smad signaling. | TOPK promotes epithelial-mesenchymal transition and invasion of breast cancer cells through upregulation of TBX3 in TGF-β1/Smad signaling.
Lee YJ, Park JH, Oh SM. | 08/22/2020 |
| Authors demonstrate that COL1A2 mediates the pro- and anti-migratory effects of TBX3 in chondrosarcoma and fibrosarcoma cells respectively. Data reveal that the AKT1/TBX3/COL1A2 axis plays an important role in sarcomagenesis. | COL1A2 is a TBX3 target that mediates its impact on fibrosarcoma and chondrosarcoma cell migration.
Omar R, Cooper A, Maranyane HM, Zerbini L, Prince S. | 06/13/2020 |
| TBX3 promotes progression of pre-invasive breast cancer cells in ductal carcinoma in situ by directly up-regulating SLUG expression and inducing epithelial mesenchymal transformation. | TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG.
Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMillan CD, Williams KC, Leong HS, Brackstone M, Torchia J, Chambers AF, Tuck AB., Free PMC Article | 04/18/2020 |