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    MIR584 microRNA 584 [ Homo sapiens (human) ]

    Gene ID: 693169, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells.

    Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells.
    Yang E, Hong Y, Xuan C, Xu J, Ding Q, Zhao S, Ye H, Fan X, Jiang Z, Zhang S, Ding X.

    12/20/2023
    The neuropathological mechanism of EV-A71 infection attributes to inflammatory pryoptosis and viral replication via activating the hsa_circ_0045431/ hsa_miR_584/NLRP3 regulatory axis.

    The neuropathological mechanism of EV-A71 infection attributes to inflammatory pryoptosis and viral replication via activating the hsa_circ_0045431/ hsa_miR_584/NLRP3 regulatory axis.
    Hu Y, Yu Y, Yang R, Wang R, Pu D, Wang Y, Fan J, Zhang Y, Song J., Free PMC Article

    08/31/2023
    Circ_0079530 stimulates THBS2 to promote the malignant progression of non-small cell lung cancer by sponging miR-584-5p.

    Circ_0079530 stimulates THBS2 to promote the malignant progression of non-small cell lung cancer by sponging miR-584-5p.
    Fang K, Deng Y, Yang P, Zhang Y, Luo D, Wang F, Cai Z, Liu Y.

    05/24/2023
    Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.

    Regulations of LINC0196/miR-584-5p/miR-34a-5p/TRIM59 on Progression of Pediatric Neuroblastoma.
    Xie P, Wang Z, Chen X, Han Y, Yang M, Ye Z.

    10/22/2022
    Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.

    Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
    Chen X, Li G, Zhong G, Chen J, Feng L, Zhang T, Tang Z.

    10/15/2022
    Downregulated long intergenic non-coding RNA 00,174 represses malignant biological behaviors of lung cancer cells by regulating microRNA-584-3p/ribosomal protein S24 axis.

    Downregulated long intergenic non-coding RNA 00,174 represses malignant biological behaviors of lung cancer cells by regulating microRNA-584-3p/ribosomal protein S24 axis.
    Wang S, Xia L, Zhang B, Zhang H, Lan F.

    08/13/2022
    Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.

    Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.
    Ma D, Qin Y, Huang C, Chen Y, Han Z, Zhou X, Liu H., Free PMC Article

    09/4/2021
    Knockdown of microRNA-584 promotes dental pulp stem cells proliferation by targeting TAZ.

    Knockdown of microRNA-584 promotes dental pulp stem cells proliferation by targeting TAZ.
    Tian S, Liu Y, Dong F, Dou Y, Li W, Wang J., Free PMC Article

    07/31/2021
    circRNA 001306 enhances hepatocellular carcinoma growth by up-regulating CDK16 expression via sponging miR-584-5p.

    circRNA 001306 enhances hepatocellular carcinoma growth by up-regulating CDK16 expression via sponging miR-584-5p.
    Liu Q, Wang C, Jiang Z, Li S, Li F, Tan HB, Yue SY., Free PMC Article

    05/22/2021
    MiRNA-584 suppresses the progression of NK/T-cell lymphoma by targeting FOXO1.

    MiRNA-584 suppresses the progression of NK/T-cell lymphoma by targeting FOXO1.
    Wang CC, Han L, Hou YH, Ying XY.

    04/3/2021
    MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1.

    MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1.
    Yang L, Ma HL.

    02/13/2021
    Fluctuating expression of miR-584 in primary and high-grade gastric cancer.

    Fluctuating expression of miR-584 in primary and high-grade gastric cancer.
    Ebrahimi Ghahnavieh L, Tabatabaeian H, Ebrahimi Ghahnavieh Z, Honardoost MA, Azadeh M, Moazeni Bistgani M, Ghaedi K., Free PMC Article

    02/2/2021
    Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway.

    Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway.
    Shao Z, Pan Q, Zhang Y.

    01/16/2021
    Hsa-miR-584-5p as a novel candidate biomarker in Turkish men with severe coronary artery disease.

    Hsa-miR-584-5p as a novel candidate biomarker in Turkish men with severe coronary artery disease.
    Coban N, Pirim D, Erkan AF, Dogan B, Ekici B.

    10/10/2020
    In vitro functional assays showed miR-584-5p depletion decreased HCC cell proliferation, cell migration, and cell invasion. Moreover, miR-584-5p functions by directly targeting KCNE2, and it in turn, mediates the effects of miR-584-5p on HCC cell behaviors.

    miR-584-5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2.
    Wei H, Wang J, Xu Z, Lu Y, Wu X, Zhuo C, Tan C, Tang Q, Pu J., Free PMC Article

    05/30/2020
    This study identifies FLI1 exonic circular RNAs as a new oncogenic driver that promotes tumor metastasis through the miR584-ROCK1 pathway. Importantly, serum exosomal FECR1 may serve as a promising biomarker to track disease progression of small cell lung cancer (SCLC)

    FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.
    Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, Pan X, Zhang X, Zhou L, Yu D, Li A, Hu JF, Cui J.

    04/25/2020
    Long noncoding RNA LOC101927746 interacts with miR-584-3p which targets SSRP1. LOC101927746/miR-584-3p/SSRP1 pathway modulates colorectal cancer progression.

    A novel lncRNA LOC101927746 accelerates progression of colorectal cancer via inhibiting miR-584-3p and activating SSRP1.
    Huang H, Cai L, Li R, Ye L, Chen Z.

    11/9/2019
    Low miR584 expression is associated with proliferation and invasion of pancreatic cancer.

    MicroRNA‑584 directly targets CCND1 and inhibits cell proliferation and invasion in pancreatic cancer.
    Chen G, Hu M, Qu X, Wang K, Qu Y.

    06/1/2019
    miR5845p also inhibited the expression of MMP4 and Slug, which are involved in tumor invasion and metastasis. Taken together, these results indicated that the miR5845p/MMP14 axis may serve as an anticancer target in the treatment of nonsmallcell lung cancer patients.

    miR‑584‑5p regulates migration and invasion in non‑small cell lung cancer cell lines through regulation of MMP‑14.
    Guo T, Zheng C, Wang Z, Zheng X.

    05/25/2019
    These findings identify a previously undefined role for miR-584-5p/HDAC1/eIF4E3 in regulating DNA repair, microtubule dynamics, and stemness in medulloblastoma and set the stage for a new way to treat medulloblastoma using miR-584-5p.

    MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma.
    Abdelfattah N, Rajamanickam S, Panneerdoss S, Timilsina S, Yadav P, Onyeagucha BC, Garcia M, Vadlamudi R, Chen Y, Brenner A, Houghton P, Rao MK., Free PMC Article

    05/4/2019
    Our results demonstrate a tumor suppressor function for miR-584-3p in glioma, where it inhibits the vasculogenic mimicry of tumor cells by antagonizing hypoxia-induced ROCK1-dependent stress fiber formation.

    MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation.
    Xu S, Zhang J, Xue H, Guo X, Han X, Li T, Guo X, Gao X, Liu Q, Li G.

    04/27/2019
    These data demonstrate that miR-584-3p directly targets the MMP-14 promoter to repress YY1-facilitated MMP-14 expression and inhibits the progression of gastric cancer.

    miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression.
    Zheng L, Chen Y, Ye L, Jiao W, Song H, Mei H, Li D, Yang F, Li H, Huang K, Tong Q., Free PMC Article

    03/23/2019
    Two miRNAs, miR-584-5p and miR-1249, that matched with the PB2 binding sequence, dramatically down-regulated PB2 expression, and inhibited replication of H5N1 and H1N1 influenza A virus strains in A549 cells.

    The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome.
    Wang R, Zhang YY, Lu JS, Xia BH, Yang ZX, Zhu XD, Zhou XW, Huang PT., Free PMC Article

    06/16/2018
    Data show that TUSC2 is a direct target of miR-584, which is transcriptionally regulated by TWIST1.

    TWIST1/miR-584/TUSC2 pathway induces resistance to apoptosis in thyroid cancer cells.
    Orlandella FM, Di Maro G, Ugolini C, Basolo F, Salvatore G., Free PMC Article

    03/3/2018
    Results show that MiR-584-5p is down-regulated in human gastric cancer (GC) tissues and cells, and indicated that miR-584-5p downregulation is vital for the development and progression of GC.

    Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer.
    Li Q, Li Z, Wei S, Wang W, Chen Z, Zhang L, Chen L, Li B, Sun G, Xu J, Li Q, Wang L, Xu Z, Xia Y, Zhang D, Xu H, Xu Z., Free PMC Article

    02/10/2018
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