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    MIR608 microRNA 608 [ Homo sapiens (human) ]

    Gene ID: 693193, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.

    Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.
    Liu J, Qiao X, Liu J, Zhong M.

    03/12/2022
    Knockdown of long non-coding MIR210HG inhibits cell proliferation, migration, and invasion in hepatoblastoma via the microRNA-608-FOXO6 axis.

    Knockdown of long non-coding MIR210HG inhibits cell proliferation, migration, and invasion in hepatoblastoma via the microRNA-608-FOXO6 axis.
    Duan Y, Wu H, Hao X, Li F, Liu J, Zhu C, Dong Q., Free PMC Article

    12/25/2021
    MiR-608 overexpression in idiopathic pulmonary fibrosis (IPF).

    MiR-608 overexpression in idiopathic pulmonary fibrosis (IPF).
    Epstein Shochet G, Israeli-Shani L, Kains I, Wand O, Shitrit D., Free PMC Article

    09/11/2021
    MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes.

    MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes.
    Gu W, Wen D, Lu H, Zhang A, Wang H, Du J, Zeng L, Jiang J.

    02/13/2021
    miR-608 rs4919510 Polymorphism May Affect Susceptibility to Colorectal Cancer by Upregulating MRPL43 Expression.

    miR-608 rs4919510 Polymorphism May Affect Susceptibility to Colorectal Cancer by Upregulating MRPL43 Expression.
    Zhu X, Liu Y, Xu J, Cheng Z, Yu Y, Chu M, Lu X, Yuan W.

    11/28/2020
    Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.

    Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
    Zhang X, Fang J, Chen S, Wang W, Meng S, Liu B., Free PMC Article

    08/22/2020
    he upregulation of miR-608 reduced the expression of HOXC4 in the uveal melanoma cells, which was rescued by overexpression of MALAT1. Hence, MALAT1 could upregulate the HOXC4 by binding to miR-608.

    Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4.
    Wu S, Chen H, Zuo L, Jiang H, Yan H., Free PMC Article

    08/12/2020
    the miRNA-608 rs4919510 G>C polymorphism may have a coronary artery lesion-related relationship with Kawasaki disease susceptibility

    The miRNA-608 rs4919510 G>C polymorphism confers reduce coronary injury of Kawasaki disease in a Southern Chinese population.
    Wang Y, Lu Z, Fu L, Tan Y, Che D, Huang P, Pi L, Xu Y, Liang Q, Zhang L, Qiu X, Gu X., Free PMC Article

    07/18/2020
    the increased cisplatin sensitivity induced by miR608 overexpression was reversed by transfection of TEAD2 in nonsmall cell lung cancer (NSCLC) cells. The present data suggested that miR608 may represent a novel candidate biomarker for the evaluation of cisplatin sensitivity in patients with NSCLC.

    MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2.
    Wang Y, Li F, Ma D, Gao Y, Li R, Gao Y., Free PMC Article

    02/8/2020
    The rs4919510 polymorphism in miR-608 is associated with cancer risk and prognosis (meta-analysis).

    The role of microRNA-608 polymorphism on the susceptibility and survival of cancer: a meta-analysis.
    Dai ZM, Lv JR, Liu K, Lei XM, Li W, Wu G, Liu XH, Zhu YX, Hao Q, Dai ZJ., Free PMC Article

    11/30/2019
    MIR608 suppressed lung adenocarcinoma invasion and migration by targeting MIF protein.

    MiR-608 exerts tumor suppressive function in lung adenocarcinoma by directly targeting MIF.
    Yu HX, Wang XM, Han XD, Cao BF.

    11/16/2019
    Studied microRNA 4513 and microRNA 608 single nucleotide polymorphisms (SNPs) as biomarkers in prognosis and survival in epidermal growth factor receptor targeted tyrosine kinase inhibitor treated lung adenocarcinoma patients and in an in vivo model.

    miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs.
    Zhang N, Li Y, Zheng Y, Zhang L, Pan Y, Yu J, Yang M.

    10/26/2019
    GG genotype of mir608:rs4919510 had a 4.56-fold increased risk of high expression of IL-6 compared with patients with the CC genotype and is associated with Esophageal Squamous Cell Carcinoma.

    Circulating Interleukin-6 is Associated with Prognosis and Genetic Polymorphisms of MIR608 in Patients with Esophageal Squamous Cell Carcinoma.
    Yang PW, Huang PM, Yong LS, Chang YH, Wu CW, Hua KT, Hsieh MS, Lee JM.

    03/23/2019
    Low miR608 expression is associated with gastric cancer.

    The long noncoding RNA NORAD promotes the growth of gastric cancer cells by sponging miR-608.
    Miao Z, Guo X, Tian L.

    01/19/2019
    The CC genotype of rs4919510 of miR608 contributes to the metastatic features of the colorectal cancer.

    Investigating the Association Between miR-608 rs4919510 and miR-149 rs2292832 with Colorectal Cancer in Iranian Population.
    Ranjbar R, Chaleshi V, Aghdaei HA, Morovvati S.

    11/10/2018
    miR-608 inhibits hepatocellular carcinoma cell proliferation possibly via targeting BET family protein BRD4.

    microRNA-608 inhibits human hepatocellular carcinoma cell proliferation via targeting the BET family protein BRD4.
    He L, Meng D, Zhang SH, Zhang Y, Deng Z, Kong LB.

    10/13/2018
    Authors present the first evidence that miR-608 behaves as a tumour suppressor in A549 and SK-LU-1 cells through the regulation of AKT2.

    miR-608 regulates apoptosis in human lung adenocarcinoma via regulation of AKT2.
    Othman N, Nagoor NH.

    07/28/2018
    Results indicatedthat miR-608 rs4919510 polymorphism may contribute to the decreased cancer susceptibility and could be a promising target to forecast cancer risk for clinical practice [Meta-Analysis].

    Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects.
    Liu H, Zhou Y, Liu Q, Xiao G, Wang B, Li W, Ye D, Yu S., Free PMC Article

    03/24/2018
    genotype CC and allele C of miR-608 rs4919510 could decrease predisposition to 0-II stage CRC, mutants of pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209 increased recurrent risk in surgically resected CRC individuals receiving adjuvant chemo-radiotherapy and II stage patients, respectively.

    MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals.
    Ying HQ, Peng HX, He BS, Pan YQ, Wang F, Sun HL, Liu X, Chen J, Lin K, Wang SK., Free PMC Article

    03/3/2018
    In the present meta-analysis, no relationships between miR-608 rs4919510 polymorphism (C>G) and the risk of breast cancer were found.

    A meta-analysis: Is there any association between MiR-608 rs4919510 polymorphism and breast cancer risks?
    Wang J, Kong X, Xing Z, Wang X, Zhai J, Fang Y, Gao J., Free PMC Article

    12/16/2017
    During gemcitabine resistance induction in pancreatic cancer cells, miR-608 which is targeting RRM1 and CDA is downregulated which leads to upregulation of these genes.

    MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells.
    Rajabpour A, Afgar A, Mahmoodzadeh H, Radfar JE, Rajaei F, Teimoori-Toolabi L.

    11/25/2017
    We obtained, however, moderate to weak evidence for replication in one case; specifically, rs4919510 in MIR608 had a p-value of 5.1x10-3 for association with Achilles tendon injury, corresponding to a 7% chance of false replication

    Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy.
    Kim SK, Roos TR, Roos AK, Kleimeyer JP, Ahmed MA, Goodlin GT, Fredericson M, Ioannidis JP, Avins AL, Dragoo JL., Free PMC Article

    08/26/2017
    miR-608 CC genotype is associated with worse outcome when compared to the CG/GG genotypes in rectal cancer patients treated with neoadjuvant systemic chemotherapy followed by CRT, surgery and adjuvant chemotherapy.

    Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.
    Sclafani F, Chau I, Cunningham D, Lampis A, Hahne JC, Ghidini M, Lote H, Zito D, Tabernero J, Glimelius B, Cervantes A, Begum R, De Castro DG, Wilson SH, Peckitt C, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Braconi C, Valeri N., Free PMC Article

    08/12/2017
    These findings provide evidence that the miR-608 rs4919510 polymorphism may modify cancer susceptibility in a type-specific manner. Furthermore, SEMA4G may function as an oncogene or tumour suppressor to regulate tumour development in a type-specific manner. Further studies with experimental evaluations are warranted.

    The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type.
    Wu S, Yuan W, Shen Y, Lu X, Li Y, Tian T, Jiang L, Zhuang X, Wu J, Chu M.

    07/15/2017
    MIR608 polymorphisms are associated with the risk of head and neck squamous cell carcinoma.

    Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study.
    Miao L, Wang L, Zhu L, Du J, Zhu X, Niu Y, Wang R, Hu Z, Chen N, Shen H, Ma H., Free PMC Article

    03/18/2017
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