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    Cysltr2 cysteinyl leukotriene receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 70086, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.

    The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
    Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM., Free PMC Article

    10/23/2021
    this study shows that cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism

    Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism.
    Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA., Free PMC Article

    08/31/2019
    CysLT2 receptors were constitutively expressed in the lung, and expression was strengthened in asthmatic mice. Activation of CysLT2 receptors was functionally involved in allergic leukocyte infiltration into the lung.

    Increased expression of CysLT(2) receptors in the lung of asthmatic mice and role in allergic responses.
    Matsuda M, Tabuchi Y, Nishimura K, Nakamura Y, Sekioka T, Kadode M, Kawabata K, Nabe T.

    01/19/2019
    CysLT2R signaling, IL-33-dependent group 2 innate lymphoid cell expansion, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and aspirin sensitivity. CysLT2R-targeted drugs may interrupt these processes.

    Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.
    Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA., Free PMC Article

    10/6/2018
    It plays a critical role in Ab1e42-induced neurotoxicity.

    Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo.
    Tang SS, Hong H, Chen L, Mei ZL, Ji MJ, Xiang GQ, Li N, Ji H.

    10/4/2014
    The CysLT(1) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils

    Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice.
    Shi WZ, Zhao CZ, Zhao B, Shi QJ, Zhang LH, Wang YF, Fang SH, Lu YB, Zhang WP, Wei EQ., Free PMC Article

    07/26/2014
    Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury.

    Multiple-site activation of the cysteinyl leukotriene receptor 2 is required for exacerbation of ischemia/reperfusion injury.
    Ni NC, Ballantyne LL, Mewburn JD, Funk CD.

    03/22/2014
    LTC4 activates mouse platelets exclusively through CysLT2R. LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 receptors.

    Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
    Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA., Free PMC Article

    02/22/2014
    CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice.

    [Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice].
    Wang H, Shi Q, Shi W, Zhang X, Wang X, Zhang L, Fang S, Lu Y, Zhang W, Wei E.

    06/29/2013
    CysLT2R negatively regulates the development of cys-LT-dependent T helper cell (Th)2 pulmonary inflammation by inhibiting both CysLT1R signaling and house dust mite-induced LTC4S-dependent cell surface expression of CysLT1R on dendritic cells.

    Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.
    Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y., Free PMC Article

    01/12/2013
    These findings establish a role for eosinophil-derived cysteinyl leukotriene and the CysLT(2)R in the hyperkeratosis and fibrosis of allergic skin inflammation.

    Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
    Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS., Free PMC Article

    05/26/2012
    Results implicate the CysLT(2)R in the progression of ischemic retinopathy.

    The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy.
    Barajas-Espinosa A, Ni NC, Yan D, Zarini S, Murphy RC, Funk CD.

    05/26/2012
    These results suggest that a lack of neuronal expression of CysLTR in the murine colonic myenteric plexus attenuates colitis disease progression.

    Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract.
    Barajas-Espinosa A, Ochoa-Cortes F, Moos MP, Ramirez FD, Vanner SJ, Funk CD., Free PMC Article

    10/8/2011
    Endothelium-targeted overexpression of CysLT2R aggravates myocardial ischemia-reperfusion injury by increasing endothelial permeability and by accelerating left ventricular remodeling, and impaired cardiac performance.

    Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.
    Jiang W, Hall SR, Moos MP, Cao RY, Ishii S, Ogunyankin KO, Melo LG, Funk CD., Free PMC Article

    01/21/2010
    CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.

    CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.
    Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA., Free PMC Article

    01/21/2010
    findings show that CysLT1 receptor attenuates while CysLT2 receptor facilitates oxygen glucose deprivation -induced PC12 cell death

    Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death.
    Sheng WW, Li CT, Zhang WP, Yuan YM, Hu H, Fang SH, Zhang L, Wei EQ.

    01/21/2010
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