| In silico exploration and molecular dynamics of deleterious SNPs on the human TERF1 protein triggering male infertility. | In silico exploration and molecular dynamics of deleterious SNPs on the human TERF1 protein triggering male infertility.
Harmak H, Redouane S, Charoute H, Aniq Filali O, Barakat A, Rouba H. | 12/26/2023 |
| Structural basis of telomeric nucleosome recognition by shelterin factor TRF1. | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD., Free PMC Article | 08/28/2023 |
| In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2. | In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2.
Abreu PL, Lee YW, Azzalin CM., Free PMC Article | 10/8/2022 |
| Compartmentalization of telomeres through DNA-scaffolded phase separation. | Compartmentalization of telomeres through DNA-scaffolded phase separation.
Jack A, Kim Y, Strom AR, Lee DSW, Williams B, Schaub JM, Kellogg EH, Finkelstein IJ, Ferro LS, Yildiz A, Brangwynne CP., Free PMC Article | 02/12/2022 |
| Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA. | Structure, dynamics, and regulation of TRF1-TIN2-mediated trans- and cis-interactions on telomeric DNA.
Pan H, Kaur P, Barnes R, Detwiler AC, Sanford SL, Liu M, Xu P, Mahn C, Tang Q, Hao P, Bhattaram D, You C, Gu X, Lu W, Piehler J, Xu G, Weninger K, Riehn R, Opresko PL, Wang H., Free PMC Article | 11/22/2021 |
| Prognostic value of TERF1 expression in prostate cancer. | Prognostic value of TERF1 expression in prostate cancer.
Dos Santos GA, Viana NI, Pimenta R, Guimarães VR, de Camargo JA, Romão P, Reis ST, Leite KRM, Srougi M. | 09/11/2021 |
| Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population. | Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.
Chang X, Gurung RL, Wang L, Jin A, Li Z, Wang R, Beckman KB, Adams-Haduch J, Meah WY, Sim KS, Lim WK, Davila S, Tan P, Teo JX, Yeo KK, M Y, Liu S, Lim SC, Liu J, van Dam RM, Friedlander Y, Koh WP, Yuan JM, Khor CC, Heng CK, Dorajoo R., Free PMC Article | 08/7/2021 |
| TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR155. | TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR‑155.
Chen W, He LN, Liang Y, Zeng X, Wu CP, Su MQ, Cheng Y, Liu JH., Free PMC Article | 05/15/2021 |
| Dynamics of TRF1 organizing a single human telomere. | Dynamics of TRF1 organizing a single human telomere.
Li X, Wang M, Zheng W, Huang W, Wang Z, Jin K, Liu L, Yu Z., Free PMC Article | 02/13/2021 |
| Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma. | Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
Vaiciulis P, Liutkeviciene R, Liutkevicius V, Vilkeviciute A, Gedvilaite G, Uloza V., Free PMC Article | 02/13/2021 |
| The relationship between leukocyte telomere length and TERT, TRF1 single nucleotide polymorphisms in healthy people of different age groups. | The relationship between leukocyte telomere length and TERT, TRF1 single nucleotide polymorphisms in healthy people of different age groups.
Gedvilaite G, Vilkeviciute A, Kriauciuniene L, Banevičius M, Liutkeviciene R. | 12/12/2020 |
| Effect of TRF1 rs3863242 polymorphism on telomere length in omethoate-exposed workers. | Effect of TRF1 rs3863242 polymorphism on telomere length in omethoate-exposed workers.
Zhou X, Wei W, Duan X, Zhang H, Feng X, Wang T, Wang P, Ding M, Liu S, Li L, Yao W, Wang Q, Acquaye RM, Liang H, Wang W, Yang Y. | 10/24/2020 |
| Persistent telomere cohesion protects aged cells from premature senescence. | Persistent telomere cohesion protects aged cells from premature senescence.
Azarm K, Bhardwaj A, Kim E, Smith S., Free PMC Article | 09/5/2020 |
| BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1. | BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1.
Wu S, Ge Y, Li X, Yang Y, Zhou H, Lin K, Zhang Z, Zhao Y., Free PMC Article | 08/22/2020 |
| Authors found that TPP1(ACD) upon binding to TIN2 induces changes that expand TIN2 binding capacity, such that TIN2 can accommodate both TRF1 and TRF2 simultaneously. Authors suggest a molecular model that explains why ACD is essential for the stable formation of TRF1-TIN2-TRF2 core complex. | Human Telomere Repeat Binding Factor TRF1 Replaces TRF2 Bound to Shelterin Core Hub TIN2 when TPP1 Is Absent.
Janovič T, Stojaspal M, Veverka P, Horáková D, Hofr C. | 06/20/2020 |
| NCAPH2 promotes telomere stability, possibly through a direct interaction with the TRF1 shelterin component | Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.
Wallace HA, Rana V, Nguyen HQ, Bosco G., Free PMC Article | 06/6/2020 |
| The study describes the identification of a novel splice variant of TERF1/PIN2, one of the main components of the telomeric shelterin complex. This new splice variant is identical to TERF1, apart from a 30 amino acid internal insertion near to the C-terminus of TERF1. The novel tissue and stem cell specific TERF1 splice variant is downregulated in tumour cells. | A Novel Tissue and Stem Cell Specific TERF1 Splice Variant Is Downregulated in Tumour Cells.
Morcos YAT, Najjar G, Meessen S, Witt B, Azoitei A, Kumar M, Wakileh G, Schwarz K, Schrezenmeier H, Zengerling F, Bolenz C, Günes C., Free PMC Article | 05/16/2020 |
| we present an analysis of the sequence and structural features governing TNKS interactions with two model binding partners: the PARylated partner telomeric repeat-binding factor 1 (TRF1) and the non-PARylated partner GDP-mannose 4,6-dehydratase (GMD). | Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase.
Eisemann T, Langelier MF, Pascal JM., Free PMC Article | 05/9/2020 |
| The study presents a comprehensive analysis of telomeres in the context of obesity, associated with dysregulation of the shelterin components that was partially explained by TRF1 upregulation that could not be reversed by the observed adaptive non-enzymatic antioxidant response. | TRF1 as a major contributor for telomeres' shortening in the context of obesity.
Grun LK, Teixeira NDR Jr, Mengden LV, de Bastiani MA, Parisi MM, Bortolin R, Lavandoski P, Pierdoná V, Alves LB, Moreira JCF, Mottin CC, Jones MH, Klamt F, Padoin AV, Guma FCR, Barbé-Tuana FM. | 09/28/2019 |
| in vitro analysis reveals that TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops | TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops.
Lee YW, Arora R, Wischnewski H, Azzalin CM., Free PMC Article | 07/27/2019 |
| TRF1 and TRF2 may be both specific to peripheral blood serum of Alzheimer's disease (AD), and may be related to the development of AD | Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.
Wu Q, Han D, Zhang J, Li X. | 07/13/2019 |
| TRF1TRFH and TRF2TRFH proteins have a conserved but different interface responsible for the protein-protein/peptide interactions that exist in the corresponding dimers | The structurally similar TRFH domain of TRF1 and TRF2 dimers shows distinct behaviour towards TIN2.
Kalathiya U, Padariya M, Baginski M. | 05/4/2019 |
| Findings suggest that rescuing naturally decreased TRF1 levels during mouse aging using AAV9-TRF1 gene therapy results in an improved health span. | Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span.
Derevyanko A, Whittemore K, Schneider RP, Jiménez V, Bosch F, Blasco MA., Free PMC Article | 07/21/2018 |
| Results provide evidence that TRF1 phosphorylation on T271 plays an important role in modulating its activity in both telomerease-expressing and alternative lengthening of telomeres cells. | TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.
Ho A, Wilson FR, Peragine SL, Jeyanthan K, Mitchell TR, Zhu XD., Free PMC Article | 06/16/2018 |
| Both TRF1 and TRF2 were overexpressed in prostate cancer. There was no specificity of TRF2 in prostate cancer, while TRF1 may be associated with prostate cancer progression. | Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.
Chen W, Wang Y, Li F, Lin W, Liang Y, Ma Z., Free PMC Article | 04/28/2018 |