| Downregulation of miR-144 blocked the proliferation and invasion of nerve cells in Hirschsprung disease by regulating Transcription Factor AP 4 (TFAP4). | Downregulation of miR-144 blocked the proliferation and invasion of nerve cells in Hirschsprung disease by regulating Transcription Factor AP 4 (TFAP4).
Zheng H, Wu D, Chen H, Bai J, Fang Y. | 08/30/2023 |
| Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis. | Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.
Potts MA, Mizutani S, Garnham AL, Li Wai Suen CSN, Kueh AJ, Tai L, Pal M, Strasser A, Herold MJ., Free PMC Article | 06/8/2023 |
| TFAP4 Activates IGF2BP1 and Promotes Progression of Non-Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification. | TFAP4 Activates IGF2BP1 and Promotes Progression of Non-Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification.
Shen Q, Xu Z, Sun G, Wang H, Zhang L. | 12/10/2022 |
| Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway. | Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.
Guo J, Fang X, Liu G, Zhou J, Zeng L, Yu B. | 07/23/2022 |
| Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma. | Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.
Wang W, Wu J, Dai X, Cheng K., Free PMC Article | 02/26/2022 |
| Upregulating microRNA-373-3p promotes apoptosis and inhibits metastasis of hepatocellular carcinoma cells. | Upregulating microRNA-373-3p promotes apoptosis and inhibits metastasis of hepatocellular carcinoma cells.
Li H, Wang N, Xu Y, Chang X, Ke J, Yin J., Free PMC Article | 02/26/2022 |
| Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes. | Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes.
Tonc E, Takeuchi Y, Chou C, Xia Y, Holmgren M, Fujii C, Raju S, Chang GS, Iwamoto M, Egawa T., Free PMC Article | 01/8/2022 |
| An integrated pan-cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity. | An integrated pan-cancer analysis of TFAP4 aberrations and the potential clinical implications for cancer immunity.
Liu JN, Kong XS, Sun P, Wang R, Li W, Chen QF., Free PMC Article | 09/25/2021 |
| The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression. | The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.
Thomas R, Trapani D, Goodyer-Sait L, Tomkova M, Fernandez-Rozadilla C, Sahnane N, Woolley C, Davis H, Chegwidden L, Kriaucionis S, Maughan T, Leedham S, Palles C, Furlan D, Tomlinson I, Lewis A., Free PMC Article | 12/5/2020 |
| TFAP4-66aa-uORF inhibited the TFAP4/LINC00520/miR-520f-3p feedback loop. | Transcription factor AP-4 (TFAP4)-upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA-520f-3p feedback loop.
Wang Y, Yang C, Liu X, Zheng J, Zhang F, Wang D, Xue Y, Li X, Shen S, Shao L, Yang Y, Liu L, Ma J, Liu Y., Free PMC Article | 03/21/2020 |
| TFAP4 promotes hepatocellular carcinoma invasion and metastasis by inducing epithelial-mesenchymal transition and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway. | TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway.
Huang T, Chen QF, Chang BY, Shen LJ, Li W, Wu PH, Fan WJ., Free PMC Article | 12/14/2019 |
| These results provide new insight into the mechanisms underlying hyperactivation of the Wnt/beta-catenin pathway in hepatocellular carcinoma, as well the oncogenic ability of TFAP4 to enhance the tumor-forming ability of hepatocellular carcinoma cells via its binding to the promoters of DVL1 (dishevelled segment polarity protein 1) and LEF1 (lymphoid enhancer binding factor 1). | Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.
Song J, Xie C, Jiang L, Wu G, Zhu J, Zhang S, Tang M, Song L, Li J., Free PMC Article | 08/24/2019 |
| TRIB2 suppresses cellular senescence through interaction with AP4 to down-regulate p21 expression. | TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling.
Hou Z, Guo K, Sun X, Hu F, Chen Q, Luo X, Wang G, Hu J, Sun L., Free PMC Article | 06/8/2019 |
| TFAP4 is a key regulator of MYCN-amplified neuroblastom | Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.
Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, Califano A, Yamashiro DJ., Free PMC Article | 02/23/2019 |
| Findings identify LAPTM4B as a direct AP4 target gene and the interaction of AP4 and LAPTM4B plays an important role in breast cancer progression.Implications: This study demonstrates that AP4 promotes cell growth, migration, invasion, and cisplatin resistance through upregulation of LAPTM4B expression. | The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression.
Wang L, Meng Y, Xu JJ, Zhang QY. | 02/23/2019 |
| AP4-associated signatures are conserved between murine adenomas and human colorectal cancer samples. Results establish Ap4 as rate-limiting mediator of adenoma initiation, as well as regulator of intestinal and colonic stem cell and Paneth cell homeostasis. | Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.
Jaeckel S, Kaller M, Jackstadt R, Götz U, Müller S, Boos S, Horst D, Jung P, Hermeking H., Free PMC Article | 01/26/2019 |
| these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment. | AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.
Chen C, Cai Q, He W, Lam TB, Lin J, Zhao Y, Chen X, Gu P, Huang H, Xue M, Liu H, Su F, Huang J, Zheng J, Lin T., Free PMC Article | 06/9/2018 |
| Results show that AP4 is overexpressed in primary carcinoma compared with the non-cancerous mucosa and is up-regulated in EMT in colorectal cancer (CRC) cells. Its overexpression is correlated with liver metastasis in CRC and poor outcome. Also, The study show that USP22 binds to the promoter region of AP4 to activate its transcription. | USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
Li Y, Yang Y, Li J, Liu H, Chen F, Li B, Cui B, Liu Y., Free PMC Article | 03/24/2018 |
| Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma and that high levels of this transcription factor are associated with poor clinical outcome in this disease. | MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4.
Xue C, Yu DM, Gherardi S, Koach J, Milazzo G, Gamble L, Liu B, Valli E, Russell AJ, London WB, Liu T, Cheung BB, Marshall GM, Perini G, Haber M, Norris MD., Free PMC Article | 01/20/2018 |
| Depletion of either Arl5b or AP4 results in the accumulation of APP. | Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.
Toh WH, Tan JZ, Zulkefli KL, Houghton FJ, Gleeson PA. | 09/16/2017 |
| results indicate that AP4 is a central mediator and coordinator of cell cycle progression | AP4 is required for mitogen- and c-MYC-induced cell cycle progression.
Jackstadt R, Hermeking H., Free PMC Article | 08/8/2015 |
| the 16 SNP variants studied in the genes encoding the four units of AP-4 do not have a major role in overall CP, but SNP rs1217401 of AP4B1 is significantly associated with the risk of CP as a sequela of neonatal HIE in the Chinese population. | Genetic association study of adaptor protein complex 4 with cerebral palsy in a Han Chinese population.
Wang H, Xu Y, Chen M, Shang Q, Sun Y, Zhu D, Wang L, Huang Z, Ma C, Li T, He L, Xing Q, Zhu C. | 06/14/2014 |
| betaTrCP-dependent degradation of TFAP4 is required for the fidelity of mitotic division | Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.
D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D., Free PMC Article | 05/17/2014 |
| Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss. | AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.
Jackstadt R, Jung P, Hermeking H., Free PMC Article | 03/15/2014 |
| Elevated AP4 expression in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival. Findings imply AP4 as a new regulator of epithelial-mesenchymal transition that contributes to metastatic processes in CRC | AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.
Jackstadt R, Röh S, Neumann J, Jung P, Hoffmann R, Horst D, Berens C, Bornkamm GW, Kirchner T, Menssen A, Hermeking H., Free PMC Article | 09/28/2013 |