| Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema. | Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema.
Brouillard P, Murtomäki A, Leppänen VM, Hyytiäinen M, Mestre S, Potier L, Boon LM, Revencu N, Greene A, Anisimov A, Salo MH, Hinttala R, Eklund L, Quéré I, Alitalo K, Vikkula M., Free PMC Article | 08/4/2024 |
| TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis. | TIE1 promotes cervical cancer progression via Basigin-matrix metalloproteinase axis.
Liu P, Xie L, Wu Q, Huang L, Liu X, Li W, Cai J, Wang Z, Yang P, Cai L., Free PMC Article | 04/18/2024 |
| Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization. | Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization.
Zagkos L, Dib MJ, Cronjé HT, Elliott P, Dehghan A, Tzoulaki I, Gill D, Daghlas I., Free PMC Article | 01/31/2024 |
| Possible biallelic inheritance in TIE1 in a family with congenital lymphedema, intestinal lymphangiectasia and cutis aplasia. | Possible biallelic inheritance in TIE1 in a family with congenital lymphedema, intestinal lymphangiectasia and cutis aplasia.
Abu Shtaya A, Sukenik-Halevy R, Bazak L, Lidzbarsky GA, Gonzaga-Jauregui C, Lagovsky I, Goldberg Y, Basel-Salmon L. | 07/7/2023 |
| FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway. | FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway.
Chen E, Huang J, Chen M, Wu J, Ouyang P, Wang X, Shi D, Liu Z, Zhu W, Sun H, Yang S, Zhang B, Deng W, Qiu H, Xie F., Free PMC Article | 02/24/2023 |
| A novel cis-regulatory variant modulating TIE1 expression associated with attention deficit hyperactivity disorder in Han Chinese children. | A novel cis-regulatory variant modulating TIE1 expression associated with attention deficit hyperactivity disorder in Han Chinese children.
Chen X, Yao T, Cai J, Zhang Q, Li S, Li H, Fu X, Wu J. | 03/12/2022 |
| Involvement of small extracellular vesicle-derived TIE-1 in the chemoresistance of ovarian cancer cells. | Involvement of small extracellular vesicle-derived TIE-1 in the chemoresistance of ovarian cancer cells.
Misawa T, Toyoshima M, Kitatani K, Ishibashi M, Hasegawa-Minato J, Shigeta S, Yaegashi N. | 01/1/2022 |
| TIE1 as a Candidate Gene for Lymphatic Malformations with or without Lymphedema. | TIE1 as a Candidate Gene for Lymphatic Malformations with or without Lymphedema.
Michelini S, Ricci M, Veselenyiova D, Kenanoglu S, Kurti D, Baglivo M, Fiorentino A, Basha SH, Priya S, Serrani R, Krajcovic J, Dundar M, Dautaj A, Bertelli M., Free PMC Article | 02/27/2021 |
| Results found deregulated expression of TIE1 in non-small cell lung cancer (NSCLC) tissues to be associated with poor clinical outcome. | Metabolic gene NR4A1 as a potential therapeutic target for non-smoking female non-small cell lung cancer patients.
Sun R, Bao MY, Long X, Yuan Y, Wu MM, Li X, Bao JK., Free PMC Article | 03/28/2020 |
| Study in metastatic breast cancer patients treated with a taxane-bevacizumab combination chemotherapy revealed that overall and progression-free survival was significantly shorter in patients with a high baseline Tie1 level demonstrating the prognostic value of baseline Tie1 plasma concentration in patients with metastatic breast cancer. | High baseline Tie1 level predicts poor survival in metastatic breast cancer.
Tiainen L, Korhonen EA, Leppänen VM, Luukkaala T, Hämäläinen M, Tanner M, Lahdenperä O, Vihinen P, Jukkola A, Karihtala P, Aho S, Moilanen E, Alitalo K, Kellokumpu-Lehtinen PL., Free PMC Article | 02/15/2020 |
| Tie1 has regulatory functions in angiogenesis and vascular abnormalization as well as metastasis | Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis.
La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG., Free PMC Article | 07/20/2019 |
| We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. | Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer.
Torigata M, Yamakawa D, Takakura N., Free PMC Article | 03/10/2018 |
| Tie1 directly interacts with Tie2 to promote ANG-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 cleavage contributes to loss of ANG2 agonist activity and vascular stability | Tie1 controls angiopoietin function in vascular remodeling and inflammation.
Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P., Free PMC Article | 09/30/2017 |
| Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review] | Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.
Eklund L, Kangas J, Saharinen P., Free PMC Article | 07/8/2017 |
| In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand Ang-1, but not the receptor binding domain of Ang-2, can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK signaling in the presence of both Ang-1 and fibronectin | Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.
Dalton AC, Shlamkovitch T, Papo N, Barton WA., Free PMC Article | 07/1/2017 |
| The inhibition of Tie-2 exerted by Tie-1can be relieved by Tie-1 ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review) | Tie-1: A potential target for anti-angiogenesis therapy.
Yang P, Chen N, Jia JH, Gao XJ, Li SH, Cai J, Wang Z. | 09/17/2016 |
| T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling. | Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
Reinardy JL, Corey DM, Golzio C, Mueller SB, Katsanis N, Kontos CD., Free PMC Article | 06/28/2016 |
| The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins. | Abnormal expression of Tie1 on the valves of great saphenous varicose vein.
Wang X, Zhao R, Liu C, Qiao T. | 05/3/2014 |
| Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours. | Tie1 deficiency induces endothelial-mesenchymal transition.
Garcia J, Sandi MJ, Cordelier P, Binétruy B, Pouysségur J, Iovanna JL, Tournaire R., Free PMC Article | 09/1/2012 |
| the effects of factors activating ectodomain cleavage on both Tie1 and Tie2 within the same population of cells, and their impact on angiopoietin signalling | The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.
Singh H, Hansen TM, Patel N, Brindle NP., Free PMC Article | 05/19/2012 |
| these results suggest that the expression level of Tie1 and its physical interaction with Tie2 defines whether Ang2 functions as a Tie2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to Ang2. | Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells.
Song SH, Kim KL, Lee KA, Suh W. | 05/12/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. | Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancy.
Demir R. | 05/31/2010 |
| Provide evidence for Tie1-Tie2 complex formation on the cell surface and identify molecular surface areas essential for recognition. The Tie1-Tie2 interactions are dynamic, inhibitory, and differentially modulated by angiopoietin-1 and -2. | Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.
Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA., Free PMC Article | 04/19/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS Jr, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |