| The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma. | The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Kalita B, Sahu S, Bharadwaj A, Panneerselvam L, Martinez-Cebrian G, Agarwal M, Mathew SJ. | 02/15/2024 |
| HHEX suppresses advanced thyroid cancer by interacting with TLE3. | HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Xu Z, Feng Y, Yan Y, Jin H, Chen Y, Han Y, Huang S, Feng F, Fu H, Yin Y, Huang Y, Wang H, Cheng W. | 11/8/2023 |
| Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. | Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, Carroll JS, Somervaille TCP., Free PMC Article | 02/19/2022 |
| Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site. | Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Kornspan D, Smith Y, Nechushtan H. | 05/15/2021 |
| vour findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer | TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.
Palit SA, Vis D, Stelloo S, Lieftink C, Prekovic S, Bekers E, Hofland I, Šuštić T, Wolters L, Beijersbergen R, Bergman AM, Győrffy B, Wessels LF, Zwart W, van der Heijden MS., Free PMC Article | 05/23/2020 |
| RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/beta-catenin pathway in colorectal carcinogenesis | RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.
Liu L, Zhang Y, Wong CC, Zhang J, Dong Y, Li X, Kang W, Chan FKL, Sung JJY, Yu J. | 07/6/2019 |
| Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients. | Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.
Kashiwagi S, Fukushima W, Asano Y, Goto W, Takada K, Noda S, Takashima T, Onoda N, Ohsawa M, Hirakawa K, Ohira M., Free PMC Article | 05/12/2018 |
| Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination. | Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
Flack JE, Mieszczanek J, Novcic N, Bienz M., Free PMC Article | 09/30/2017 |
| Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. | MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
Guan H, Liu C, Fang F, Huang Y, Tao T, Ling Z, You Z, Han X, Chen S, Xu B, Chen M., Free PMC Article | 08/19/2017 |
| Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression | Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM. | 09/12/2015 |
| induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation | Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling.
Kokabu S, Sato T, Ohte S, Enoki Y, Okubo M, Hayashi N, Nojima J, Tsukamoto S, Fukushima Y, Sakata Y, Katagiri T, Rosen V, Yoda T. | 04/5/2014 |
| High TLE3 expression predicts a favorable response to taxane containing chemotherapy regimens in ovarian carcinoma. | TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma.
Samimi G, Ring BZ, Ross DT, Seitz RS, Sutherland RL, O'Brien PM, Hacker NF, Huh WK. | 08/25/2012 |
| A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis. | Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness.
Shon W, Jenkins SM, Ross DT, Seitz RS, Beck RA, Ring BZ, Okuno SH, Gibson LE, Folpe AL. | 03/17/2012 |
| Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1. | Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Carvalho LR, Brinkmeier ML, Castinetti F, Ellsworth BS, Camper SA., Free PMC Article | 07/19/2010 |
| results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development | Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors.
Nakaya HI, Beckedorff FC, Baldini ML, Fachel AA, Reis EM, Verjovski-Almeida S. | 01/21/2010 |