| Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis. | Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis.
Geng X, Xia X, Liang Z, Li S, Yue Z, Zhang H, Guo L, Ma S, Jiang S, Lian X, Zhou J, Sung LA, Wang X, Yao W., Free PMC Article | 09/23/2024 |
| Recessive TMOD1 mutation causes childhood cardiomyopathy. | Recessive TMOD1 mutation causes childhood cardiomyopathy.
Vasilescu C, Colpan M, Ojala TH, Manninen T, Mutka A, Ylänen K, Rahkonen O, Poutanen T, Martelius L, Kumari R, Hinterding H, Brilhante V, Ojanen S, Lappalainen P, Koskenvuo J, Carroll CJ, Fowler VM, Gregorio CC, Suomalainen A., Free PMC Article | 01/9/2024 |
| Suggestive evidence of the genetic association of TMOD1 and PTCSC2 polymorphisms with thyroid carcinoma in the Chinese Han population. | Suggestive evidence of the genetic association of TMOD1 and PTCSC2 polymorphisms with thyroid carcinoma in the Chinese Han population.
Tong K, Zhang C, Yang T, Guo R, Wang X, Guan R, Jin T., Free PMC Article | 11/5/2022 |
| Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments. | Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments.
Kumari R, Jiu Y, Carman PJ, Tojkander S, Kogan K, Varjosalo M, Gunning PW, Dominguez R, Lappalainen P., Free PMC Article | 05/8/2021 |
| MicroRNA-885 regulates the growth and epithelial mesenchymal transition of human liver cancer cells by suppressing tropomodulin 1 expression. | MicroRNA-885 regulates the growth and epithelial mesenchymal transition of human liver cancer cells by suppressing tropomodulin 1 expression.
Feng L, Zhang Y, Yang Q, Guo L, Yang F. | 12/26/2020 |
| Targeted regulation of miR-17-5p on TMOD1 promotes the development of cardia cancer. | Targeted regulation of miR-17-5p on TMOD1 promotes the development of cardia cancer.
Wang MY, Chen P, Wang CP. | 10/3/2020 |
| Tmod1 function in mouse and human erythroblasts, was investigated. | Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome.
Nowak RB, Papoin J, Gokhin DS, Casu C, Rivella S, Lipton JM, Blanc L, Fowler VM., Free PMC Article | 09/30/2017 |
| The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies . | Localization of the binding interface between leiomodin-2 and α-tropomyosin.
Colpan M, Tolkatchev D, Grover S, Helms GL, Cort JR, Moroz N, Kostyukova AS., Free PMC Article | 06/28/2016 |
| Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC. | Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth.
Ito-Kureha T, Koshikawa N, Yamamoto M, Semba K, Yamaguchi N, Yamamoto T, Seiki M, Inoue J. | 04/25/2015 |
| Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization. | Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3.
Lewis RA, Yamashiro S, Gokhin DS, Fowler VM., Free PMC Article | 04/4/2015 |
| The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. | Mechanism of actin filament pointed-end capping by tropomodulin.
Rao JN, Madasu Y, Dominguez R., Free PMC Article | 08/9/2014 |
| study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform) | Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres.
Kong KY, Kedes L. | 01/21/2010 |
| levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway | Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.
Pawlak G, McGarvey TW, Nguyen TB, Tomaszewski JE, Puthiyaveettil R, Malkowicz SB, Helfman DM. | 01/21/2010 |
| The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod. | Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction.
Vera C, Lao J, Hamelberg D, Sung LA. | 01/21/2010 |
| Tropomyosin requires an intact N-terminal coiled coil to interact with this protein | Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin.
Greenfield NJ, Fowler VM., Free PMC Article | 01/21/2010 |