| MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2betacc in a p53-independent manner. | MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner.
Shu J, Jiang J, Wang X, Yang X, Zhao G, Cai T., Free PMC Article | 02/29/2024 |
| DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia. | DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia.
Mishra SV, Banerjee A, Sarkar D, Thangarathnam V, Bagal B, Hasan SK, Dutt S. | 02/15/2024 |
| Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II. | Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II.
Bandak AF, Blower TR, Nitiss KC, Shah V, Nitiss JL, Berger JM., Free PMC Article | 02/14/2024 |
| To Break or Not to Break: The Role of TOP2B in Transcription. | To Break or Not to Break: The Role of TOP2B in Transcription.
Cowell IG, Casement JW, Austin CA., Free PMC Article | 11/7/2023 |
| Revisiting TOP2B-related phenotypes: Three new cases and literature review. | Revisiting TOP2B-related phenotypes: Three new cases and literature review.
Çepni E, Börklü E, Avcı Ş, Kalaycı T, Eraslan S, Kayserili H. | 07/7/2023 |
| Taspase1 Facilitates Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription. | Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription.
Oelschläger L, Stahl P, Kaschani F, Stauber RH, Knauer SK, Hensel A., Free PMC Article | 02/15/2023 |
| Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIbeta Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide. | Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.
Carvajal-Moreno J, Hernandez VA, Wang X, Li J, Yalowich JC, Elton TS., Free PMC Article | 01/28/2023 |
| TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells. | TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.
Khazeem MM, Casement JW, Schlossmacher G, Kenneth NS, Sumbung NK, Chan JYT, McGow JF, Cowell IG, Austin CA., Free PMC Article | 09/24/2022 |
| A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.
Ling EM, Baslé A, Cowell IG, van den Berg B, Blower TR, Austin CA., Free PMC Article | 08/13/2022 |
| BRCA1-BARD1 regulates transcription through modulating topoisomerase IIbeta. | BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.
Bunch H, Jeong J, Kang K, Jo DS, Cong ATQ, Kim D, Kim D, Cho DH, Lee YM, Chen BPC, Schellenberg MJ, Calderwood SK., Free PMC Article | 03/5/2022 |
| Down regulation of DNA topoisomerase IIbeta exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase. | Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase.
Yeman KB, Isik S. | 12/4/2021 |
| Topoisomerase IIbeta immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group. | Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group.
Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Riku Y, Akagi A, Oohashi W, Shofuda T, Yoshioka E, Sato Y, Taga T, Naruke Y, Ando R, Hasegawa D, Yoshida M, Sakaida T, Okada N, Watanabe H, Ozeki M, Arakawa Y, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y. | 09/18/2021 |
| Topoisomerase 2beta Induces DNA Breaks To Regulate Human Papillomavirus Replication. | Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication.
Kaminski P, Hong S, Kono T, Hoover P, Laimins L., Free PMC Article | 08/28/2021 |
| Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta. | Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta.
Khazeem MM, Cowell IG, Harkin LF, Casement JW, Austin CA. | 05/15/2021 |
| Topoisomerase 2beta mutation impairs early B-cell development. | Topoisomerase 2β mutation impairs early B-cell development.
Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns SO, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S., Free PMC Article | 01/2/2021 |
| Association of immunophenotype with expression of topoisomerase II alpha and beta in adult acute myeloid leukemia. | Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.
Michelson AP, McDonough S, Willman CL, Koegle ER, Godwin JE, Petersdorf SH, List AF, Othus M, Appelbaum FR, Radich JP, Ganapathi MK, Advani AS, Ganapathi RN., Free PMC Article | 12/5/2020 |
| NEK5 interacts with topoisomerase IIbeta and is involved in the DNA damage response induced by etoposide. | NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide.
Melo-Hanchuk TD, Slepicka PF, Pelegrini AL, Menck CFM, Kobarg J. | 09/19/2020 |
| Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIalpha to IIbeta in human stem cell derived cardiomyocytes. | Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.
Cui N, Wu F, Lu WJ, Bai R, Ke B, Liu T, Li L, Lan F, Cui M., Free PMC Article | 08/13/2020 |
| Mining topoisomerase isoforms in gastric cancer. | Mining topoisomerase isoforms in gastric cancer.
Hou G, Deng J, You X, Chen J, Jiang Y, Qian T, Bi Y, Song B, Xu Y, Yang X. | 08/13/2020 |
| Topo-2beta may be part of activation/repression of protein complexes activated by epigenetic modifying agents, differentiating signals, and inducible locus. | Status of topoisomerase-2β protein in all-trans retinoic acid-treated human neuroblastoma (SK-N-SH) cells.
Bhanothu V, Kondapi AK. | 07/11/2020 |
| TOP2B was found to play an important role in hearing development. The D1613H mutation of TOP2B co-segregated with autosomal-dominant nonsyndromic hearing loss in a Chinese family. The L721F, K1435del and D1613H mutations of TOP2B were detected in 66 sporadic cases, indicating that TOP2B could provide a novel marker in the diagnosis of deafness. | Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway.
Xia W, Hu J, Ma J, Huang J, Jing T, Deng L, Zhang J, Jiang N, Ma D, Ma Z. | 06/6/2020 |
| Mutations in TOP2B are underlie the syndromic B-cell immunodeficiency. | Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM., Free PMC Article | 01/11/2020 |
| We report here that both known type II topoisomerases Top2a and Top2b are present in mammalian mitochondria, with especially Top2b regulating the supercoiling state of mtDNA. Loss of Top2b or its inhibition by ciprofloxacin results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number. | Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.
Hangas A, Aasumets K, Kekäläinen NJ, Paloheinä M, Pohjoismäki JL, Gerhold JM, Goffart S., Free PMC Article | 06/29/2019 |
| our findings suggest that E2F1-topoII beta signaling may play a role in regulation of cell cycle exit and neuronal differentiation. | The role of E2F1-topoIIβ signaling in regulation of cell cycle exit and neuronal differentiation of human SH-SY5Y cells.
Wang Y, Zhao J, Cao C, Yan Y, Chen J, Feng F, Zhou N, Han S, Xu Y, Zhao J, Yan Y, Cui H. | 06/8/2019 |
| our data primarily indicate that topoIIbeta can be used to estimate neuronal differentiation in medulloblastoma | Immunohistochemical investigation of topoIIβ, H3K27me3 and JMJD3 expressions in medulloblastoma.
Chen J, Zhao J, Zhou X, Liu S, Yan Y, Wang Y, Cao C, Han S, Zhou N, Xu Y, Zhao J, Yan Y, Cui H. | 04/28/2018 |