| Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism. | Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.
Takahashi H, Perez-Canamas A, Lee CW, Ye H, Han X, Strittmatter SM., Free PMC Article | 10/25/2024 |
| Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions. | Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions.
Picard C, Miron J, Poirier J., Free PMC Article | 05/20/2024 |
| Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice. | Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.
Feng T, Du H, Yang C, Wang Y, Hu F. | 03/31/2024 |
| TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. | TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.
Edwards GA 3rd, Wood CA, He Y, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Xu Y, Zurhellen C, Al-Ramahi I, Jankowsky JL. | 03/31/2024 |
| TMEM106B regulates microglial proliferation and survival in response to demyelination. | TMEM106B regulates microglial proliferation and survival in response to demyelination.
Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, Arthanarisami A, Nana AL, Nguyen Q, Kim PJ, Jankowsky JL, Seeley WW, Hu F., Free PMC Article | 05/13/2023 |
| Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration. | Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
Cabron AS, Borgmeyer U, Richter J, Peisker H, Gutbrod K, Dörmann P, Capell A, Damme M., Free PMC Article | 02/4/2023 |
| TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. | TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F., Free PMC Article | 05/7/2022 |
| Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction. | Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
Stroobants S, D'Hooge R, Damme M., Free PMC Article | 12/25/2021 |
| Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. | Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A., Free PMC Article | 05/8/2021 |
| Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. | Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
Feng T, Mai S, Roscoe JM, Sheng RR, Ullah M, Zhang J, Katz II, Yu H, Xiong W, Hu F., Free PMC Article | 05/8/2021 |
| Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. | Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
Zhou X, Brooks M, Jiang P, Koga S, Zuberi AR, Baker MC, Parsons TM, Castanedes-Casey M, Phillips V, Librero AL, Kurti A, Fryer JD, Bu G, Lutz C, Dickson DW, Rademakers R., Free PMC Article | 05/8/2021 |
| Progranulin and TMEM106B: when two become wan. | Progranulin and TMEM106B: when two become wan.
Clayton EL, Isaacs AM., Free PMC Article | 05/1/2021 |
| The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. | The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.
Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M. | 03/27/2021 |
| A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. | A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination.
Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Enriquez LCM, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F., Free PMC Article | 01/2/2021 |
| Data show that the frontotemporal dementia (FTD)-causing C-terminal truncation of CHMP2B results in dendritic endolysosomal trafficking defects. Strikingly, we found that this trafficking defect could be rescued by the knockdown of the FTD risk factor Tmem106b. | Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
Clayton EL, Milioto C, Muralidharan B, Norona FE, Edgar JR, Soriano A, Jafar-Nejad P, Rigo F, Collinge J, Isaacs AM., Free PMC Article | 07/20/2019 |
| This work suggests that the protective TMEM106B haplotype may exert its effect in expansion carriers by counteracting lysosomal dysfunction resulting from a loss of C9ORF72. | Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
Nicholson AM, Zhou X, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, Phillips V, Hu F, Gendron TF, Murray ME, Dickson DW, Fryer JD, Petrucelli L, Rademakers R., Free PMC Article | 06/1/2019 |
| TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. | TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins.
Kundu ST, Grzeskowiak CL, Fradette JJ, Gibson LA, Rodriguez LB, Creighton CJ, Scott KL, Gibbons DL., Free PMC Article | 12/22/2018 |
| Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration | Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM., Free PMC Article | 09/16/2017 |
| Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). | Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).
Brady OA, Zhou X, Hu F., Free PMC Article | 10/4/2014 |