| A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. | A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.
Shi J, Wu X, Wang Z, Li F, Meng Y, Moore RM, Cui J, Xue C, Croce KR, Yurdagul A Jr, Doench JG, Li W, Zarbalis KS, Tabas I, Yamamoto A, Zhang H., Free PMC Article | 01/21/2023 |
| WDFY3 mutation alters laminar position and morphology of cortical neurons. | WDFY3 mutation alters laminar position and morphology of cortical neurons.
Schaaf ZA, Tat L, Cannizzaro N, Panoutsopoulos AA, Green R, Rülicke T, Hippenmeyer S, Zarbalis KS., Free PMC Article | 07/2/2022 |
| Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. | Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity.
Napoli E, Panoutsopoulos AA, Kysar P, Satriya N, Sterling K, Shibata B, Imai D, Ruskin DN, Zarbalis KS, Giulivi C., Free PMC Article | 12/25/2021 |
| Examining aggregates through the eyes of WDFY3/Alfy. | Examining aggregates through the eyes of WDFY3/Alfy.
Fox L, Yamamoto A., Free PMC Article | 06/12/2021 |
| Although the heterozygous depletion of the autophagy adaptor protein Alfy/Wdfy3 has no consequence in control mice, it significantly accelerates age of onset and progression of Huntington's disease pathogenesis. Alfy depletion in mice accelerates the aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative diseases. | Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.
Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A., Free PMC Article | 07/11/2020 |
| Wdfy3 plays an essential role in cardiac development, which may be mediated by modulation of Notch1 signalling. | WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Zhang S, Song Z, An L, Liu X, Hu XW, Naz A, Zhou R, Guo X, He L, Zhu H. | 06/20/2020 |
| These findings support a critical role for Wdfy3 in mitochondrial homeostasis with implications for neuron differentiation, neurodevelopment and age-dependent neurodegeneration. | Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.
Napoli E, Song G, Panoutsopoulos A, Riyadh MA, Kaushik G, Halmai J, Levenson R, Zarbalis KS, Giulivi C., Free PMC Article | 10/19/2019 |
| Data provide a novel association between WDFY3 and the RANKL-induced osteoclastogenesis pathway via the modulation of TRAF6. | Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis.
Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Zarbalis KS, Adamopoulos IE., Free PMC Article | 12/30/2017 |
| The authors report that this evolutionarily conserved protein is required for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. | Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A., Free PMC Article | 12/16/2017 |
| Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis. | Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
Han H, Wei W, Duan W, Guo Y, Li Y, Wang J, Bi Y, Li C. | 12/19/2015 |
| Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders. | Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.
Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS., Free PMC Article | 07/25/2015 |
| gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 and E16 embryonic brain, but became diffuse after birth | Expression profile of mouse BWF1, a protein with a BEACH domain, WD40 domain and FYVE domain.
Chen GY, Muramatsu H, Ichihara-Tanaka K, Muramatsu T. | 01/21/2010 |