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    TRPC1 transient receptor potential cation channel subfamily C member 1 [ Homo sapiens (human) ]

    Gene ID: 7220, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TRPC1: The housekeeper of the hippocampus.

    TRPC1: The housekeeper of the hippocampus.
    Skerjanz J, Bauernhofer L, Lenk K, Emmerstorfer-Augustin A, Leitinger G, Reichmann F, Stockner T, Groschner K, Tiapko O.

    09/19/2024
    Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.

    Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
    Qu M, Du L.

    02/21/2024
    Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling protects oxidative stress-induced COPD.

    Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.
    Shin S, Gombedza FC, Awuah Boadi E, Yiu AJ, Roy SK, Bandyopadhyay BC., Free PMC Article

    05/17/2023
    Function of TRPC1 in modulating hepatocellular carcinoma progression.

    Function of TRPC1 in modulating hepatocellular carcinoma progression.
    Qi H, Wu F, Wang H.

    02/22/2023
    TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.

    TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.
    Radoslavova S, Fels B, Pethö Z, Gruner M, Ruck T, Meuth SG, Folcher A, Prevarskaya N, Schwab A, Ouadid-Ahidouch H.

    09/17/2022
    NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/beta-catenin pathway.

    NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.
    Wan H, Gao N, Lu W, Lu C, Chen J, Wang Y, Dong H., Free PMC Article

    09/3/2022
    The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.

    The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.
    Schnipper J, Kouba S, Hague F, Girault A, Rybarczyk P, Telliez MS, Guénin S, Tebbakha R, Sevestre H, Ahidouch A, Pedersen SF, Ouadid-Ahidouch H., Free PMC Article

    08/6/2022
    Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.

    Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.
    Yart L, Frieden M, Konig S, Cohen M, Martinez de Tejada B., Free PMC Article

    05/7/2022
    Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.

    Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.
    Ke C, Long S., Free PMC Article

    04/16/2022
    Orai1alpha, but not Orai1beta, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.

    Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.
    Sanchez-Collado J, Lopez JJ, Jardin I, Berna-Erro A, Camello PJ, Cantonero C, Smani T, Salido GM, Rosado JA., Free PMC Article

    01/15/2022
    Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.

    Sigma1 Receptor Inhibits TRPC1-Mediated Ca(2+) Entry That Promotes Dopaminergic Cell Death.
    Sun Y, Sukumaran P, Singh BB.

    12/11/2021
    Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.

    Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
    Elzamzamy OM, Johnson BE, Chen WC, Hu G, Penner R, Hazlehurst LA., Free PMC Article

    10/30/2021
    Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract.

    Involvement of TRPC1 and Cyclin D1 in Human Pulmonary Artery Smooth Muscle Cells Proliferation Induced by Cigarette Smoke Extract.
    Wang X, Wang W, Liu C, Wu XJ.

    09/25/2021
    Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension.

    Correlation between classical transient receptor potential channel 1 gene polymorphism and microalbuminuria in patients with primary hypertension.
    Zhang Y, Maitikuerban B, Chen Y, Li Y, Cao Y, Xu X.

    07/17/2021
    STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry.

    STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry.
    Dyrda A, Koenig S, Frieden M.

    06/5/2021
    Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels.

    Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels.
    Stratford K, Haykal-Coates N, Thompson L, Farraj A, Hazari M., Free PMC Article

    05/8/2021
    The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.

    The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose.
    Lang HB, Xie RX, Huang ML, Fang LY, Tang YB, Zhang F.

    03/27/2021
    Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle.

    Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle.
    Baudel MASM, Shi J, Large WA, Albert AP., Free PMC Article

    03/13/2021
    TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.

    TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
    Kougioumoutzakis A, Pelletier JG, Laplante I, Khlaifia A, Lacaille JC., Free PMC Article

    02/13/2021
    TRPC1 exacerbate metastasis in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis.

    TRPC1 exacerbate metastasis in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis.
    Zhang Z, Ren L, Zhao Q, Lu G, Ren M, Lu X, Yin Y, He S, Zhu C.

    02/13/2021
    TRPC1 inhibits the proliferation and migration of estrogen receptor-positive Breast cancer and gives a better prognosis by inhibiting the PI3K/AKT pathway.

    TRPC1 inhibits the proliferation and migration of estrogen receptor-positive Breast cancer and gives a better prognosis by inhibiting the PI3K/AKT pathway.
    Zhang LY, Zhang YQ, Zeng YZ, Zhu JL, Chen H, Wei XL, Liu LJ.

    01/9/2021
    Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.

    Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
    Irnaten M, O'Malley G, Clark AF, O'Brien CJ.

    11/21/2020
    Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli.

    Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli.
    Stewart TA, Azimi I, Marcial D, Peters AA, Chalmers SB, Yapa KTDS, Thompson EW, Roberts-Thomson SJ, Monteith GR.

    09/26/2020
    Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.

    Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.
    Ko J, Myeong J, Shin YC, So I., Free PMC Article

    09/26/2020
    knockout of TRPC1 significantly attenuated cardiomyocyte hypertrophy phenotype

    Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes.
    Tang L, Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J, Wang L, Liang P.

    01/11/2020
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