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    Mir106b microRNA 106b [ Mus musculus (house mouse) ]

    Gene ID: 723925, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Knockdown of Mmu-circ-0001380 Attenuates Myocardial Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis.

    Knockdown of Mmu-circ-0001380 Attenuates Myocardial Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis.
    Wang L, Wang C, Sun Z, Du A, Shan F, Sun Z.

    11/1/2023
    MiR-106b-5p Attenuates Neuropathic Pain by Regulating the P2X4 Receptor in the Spinal Cord in Mice.

    MiR-106b-5p Attenuates Neuropathic Pain by Regulating the P2X4 Receptor in the Spinal Cord in Mice.
    Du H, Wu D, Zhong S, Wei X, Yuan Z, Gong Q.

    09/10/2022
    Deletion of the miR-25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice.

    Deletion of the miR-25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice.
    Ma H, Li X, Yu S, Hu Y, Yin M, Zhu F, Xu L, Wang T, Wang H, Li H, Zhao B, Huang Y., Free PMC Article

    02/19/2022
    A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration.

    A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration.
    Raso A, Dirkx E, Sampaio-Pinto V, El Azzouzi H, Cubero RJ, Sorensen DW, Ottaviani L, Olieslagers S, Huibers MM, de Weger R, Siddiqi S, Moimas S, Torrini C, Zentillin L, Braga L, Nascimento DS, da Costa Martins PA, van Berlo JH, Zacchigna S, Giacca M, De Windt LJ., Free PMC Article

    08/28/2021
    miR-106b suppresses pathological retinal angiogenesis.

    miR-106b suppresses pathological retinal angiogenesis.
    Ménard C, Wilson AM, Dejda A, Miloudi K, Binet F, Crespo-Garcia S, Parinot C, Pilon F, Juneau R, Andriessen EM, Mawambo G, SanGiovanni JP, De Guire V, Sapieha P., Free PMC Article

    05/29/2021
    Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.

    Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis.
    Gong L, Zhu L, Yang T.

    09/26/2020
    Role of Monocyte-Derived MicroRNA106b approximately 25 in Resilience to Social Stress.

    Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress.
    Pfau ML, Menard C, Cathomas F, Desland F, Kana V, Chan KL, Shimo Y, LeClair K, Flanigan ME, Aleyasin H, Walker DM, Bouchard S, Mack M, Hodes GE, Merad MM, Russo SJ., Free PMC Article

    08/15/2020
    miR-106b regulates neural stem cell proliferation and differentiation through direct inhibition of Tp53inp1 and Cdkn1a expression.

    miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis.
    Xia X, Lu H, Li C, Huang Y, Wang Y, Yang X, Zheng JC., Free PMC Article

    08/1/2020
    The miR-106b-25 cluster regulates atherosclerosis in mice by influencing clearance of VLDL and LDL from the plasma.

    Deletion of the Mir-106b~ 25 MicroRNA cluster attenuates atherosclerosis in Apolipoprotein E knockout mice.
    Semo J, Chernin G, Jonas M, Shimoni S, George J., Free PMC Article

    05/9/2020
    The miR106b targeted Mfn2 and regulated skeletal muscle insulin sensitivity and glucose tolerance.

    MicroRNA‑106b regulates skeletal muscle insulin sensitivity and glucose homeostasis by targeting mitofusion‑2.
    Zhang Y, He W, Gao YF, Fan ZM, Gao CL, Xia ZK.

    06/9/2018
    Berberine could attenuate oxidative stress of diabetic mice at least partly through miR-106b/SIRT1 pathway and affecting the function of islets, which might be beneficial in reducing the cardiovascular risk factors in diabetes.

    Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR-106b Expression and Up-Regulating SIRT1.
    Chen DL, Yang KY.

    01/6/2018
    miR-106b inhibited osteoblastic differentiation and bone formation partly through directly targeting bone morphogenetic protein 2.

    Silencing miR-106b accelerates osteogenesis of mesenchymal stem cells and rescues against glucocorticoid-induced osteoporosis by targeting BMP2.
    Liu K, Jing Y, Zhang W, Fu X, Zhao H, Zhou X, Tao Y, Yang H, Zhang Y, Zen K, Zhang C, Li D, Shi Q.

    12/23/2017
    miR-106b-5p and miR-17-5p are novel Smad5 regulators.

    miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation.
    Fang T, Wu Q, Zhou L, Mu S, Fu Q.

    05/20/2017
    miR-20b and miR-106b strands were differentially expressed in cerebellum of mucopolysaccharidosis type I mice.

    Differential expression of microRNAs from miR-17 family in the cerebellum of mucopolysaccharidosis type I mice.
    Pereira VG, Queiroz MT, D'Almeida V.

    01/28/2017
    The expression of miR-106b decreased over time in the Pb-exposed animals and was significantly less than the levels exhibited by the control animals at PND700.

    Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease.
    Masoud AM, Bihaqi SW, Machan JT, Zawia NH, Renehan WE.

    12/31/2016
    Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer knockdown mice and showed that miR-106b positively regulated Gli2 mRNA expression

    MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2.
    Constantin L, Wainwright BJ.

    08/20/2016
    Mir106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting Egr-2 in vitro

    MicroRNA-106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting early growth response-2 in vitro.
    Tang H, Jiang H, Zheng J, Li J, Wei Y, Xu G, Li H.

    07/30/2016
    Silencing miR-106b improves palmitic acid-induced mitochondrial dysfunction and insulin resistance in skeletal myocytes.

    Silencing miR-106b improves palmitic acid-induced mitochondrial dysfunction and insulin resistance in skeletal myocytes.
    Zhang Y, Zhao YP, Gao YF, Fan ZM, Liu MY, Cai XY, Xia ZK, Gao CL.

    03/26/2016
    Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.

    Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway.
    Chen S, Chen X, Xiu YL, Sun KX, Zhao Y., Free PMC Article

    02/6/2016
    Suggest that miR-106b-25 cluster-mediated post-transcriptional regulation of RyR2 is a potential molecular mechanism involved in paroxysmal atrial fibrillation pathogenesis.

    Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.
    Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N., Free PMC Article

    02/21/2015
    Pitx2 positively regulates miR-17-92 and miR-106b-25.

    Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.
    Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF., Free PMC Article

    08/23/2014
    MiR-106b targets Mfn2 and regulates skeletal muscle mitochondrial function and insulin sensitivity.

    MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2.
    Zhang Y, Yang L, Gao YF, Fan ZM, Cai XY, Liu MY, Guo XR, Gao CL, Xia ZK.

    05/3/2014
    Knockdown of miR-106b and miR-93 significantly induced the expression of brown fat-specific genes and promoted the accumulation of lipid-droplet in differentiating brown adipocytes.

    Identification of miR-106b-93 as a negative regulator of brown adipocyte differentiation.
    Wu Y, Zuo J, Zhang Y, Xie Y, Hu F, Chen L, Liu B, Liu F.

    11/16/2013
    The miR-106b binds in the 3' UTR of ULK1 contribute to the modulation of ULK1 expression.

    MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts.
    Wu H, Wang F, Hu S, Yin C, Li X, Zhao S, Wang J, Yan X.

    01/12/2013
    Data suggest that miR-106b/93/25 regulates neural stem cell function and is part of a network involving the insulin/IGF-FoxO pathway, which may have important implications for the homeostasis of the NSC pool during aging.

    The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation.
    Brett JO, Renault VM, Rafalski VA, Webb AE, Brunet A., Free PMC Article

    07/2/2011
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